Abstract: Disclosed is a method of improving the appearance of skin with a low-pH skin care composition that contains hydroxycinnamic acid (HCA) and a vitamin B3 compound in a synergistic combination.

Abstract: A method of identifying or evaluating synergistic combinations of actives such as skin-care actives that improve the metabolism of a cell and provides an advantage over using the actives alone. The method includes contacting cells with test agents, alone and in combination, and determining a response of the cells to the test agent(s), wherein the response corresponds to a change in a metabolic indicator associated with glycolysis and a change in a metabolic indicator associated with oxidative phosphylation.

Abstract: Low pH cosmetic compositions and methods for improving the appearance of skin. The low pH cosmetic compositions herein include a saccharide and, optionally, one or more additional skin care actives to improve the appearance of skin. The lower pH reduces or even eliminates some of the skin health and appearance drawbacks associated with saccharide induced glycation.

Abstract: A skin care product is provided. The skin care product includes a multi-component skin care composition disposed in a multi-chamber container. The multi-component skin care composition includes an aqueous carrier component and a nicotinamide riboside component disposed in separate chambers, which prevents these components from contacting one another prior to use. The aqueous carrier component and the nicotinamide riboside component can be separated from one another by one or more fluid impermeable dividing members and/or activatable elements, which upon activation enable contact between the aqueous carrier component and nicotinamide riboside component.

Abstract: Low pH cosmetic compositions and methods for improving the appearance of skin. The low pH cosmetic compositions herein include a saccharide and, optionally, one or more additional skin care actives to improve the appearance of skin. The lower pH reduces or even eliminates some of the skin health and appearance drawbacks associated with saccharide induced glycation.

Abstract: Low pH cosmetic compositions and methods for improving the appearance of skin. The low pH cosmetic compositions herein include a saccharide and, optionally, one or more additional skin care actives to improve the appearance of skin. The lower pH reduces or even eliminates some of the skin health and appearance drawbacks associated with saccharide induced glycation.

Abstract: A method of identifying or evaluating skin-care actives that improve the metabolism of a skin cell. The method includes contacting cells with a stressor and a test agent and determining a response of the cells to the stressor and test agent, based on the change in metabolic indicators associated with glycolysis and/or oxidative phosphylation. The test agent may be identified as a skin-care active when the oxidative phosphorylation and/or glycolysis response corresponds to an improvement in cellular metabolism.

Abstract: Low pH cosmetic compositions and methods for improving the appearance of skin. The low pH cosmetic compositions herein include a saccharide and, optionally, one or more additional skin care actives to improve the appearance of skin. The lower pH reduces or even eliminates some of the skin health and appearance drawbacks associated with saccharide induced glycation.

Abstract: Cosmetic methods and compositions for improving the appearance and barrier function of skin. The methods and compositions utilize a combination of niacinamide and a suitable saccharide at low pH to decrease trans-epidermal water loss in skin, reduce the size of hyperpigmented spots, and improve the appearance of skin better than their high pH counterparts.

Abstract: A method of identifying or evaluating synergistic combinations of actives such as skin-care actives that improve the metabolism of a cell and provides an advantage over using the actives alone. The method includes contacting cells with test agents, alone and in combination, and determining a response of the cells to the test agent(s), wherein the response corresponds to a change in a metabolic indicator associated with glycolysis and a change in a metabolic indicator associated with oxidative phosphylation.

Abstract: A method of identifying or evaluating synergistic combinations of actives such as skin-care actives that improve the metabolism of a cell and provides an advantage over using the actives alone. The method includes contacting cells with test agents, alone and in combination, and determining a response of the cells to the test agent(s), wherein the response corresponds to a change in a metabolic indicator associated with glycolysis and a change in a metabolic indicator associated with oxidative phosphylation.

Abstract: Cosmetic methods and compositions for improving the appearance and barrier function of skin. The methods and compositions utilize a combination of niacinamide and a suitable saccharide at low pH to decrease trans-epidermal water loss in skin, reduce the size of hyperpigmented spots, and improve the appearance of skin better than their high pH counterparts.

Abstract: A stable cosmetic agent in the form of a plurality of encapsulated particles in a core-shell configuration. The encapsulated particles are formed by coating nicotinamide riboside powder or a nicotinamide riboside containing material with one or more water-insoluble encapsulating agents. The stable encapsulated nicotinamide riboside particles exhibit less than 20% hydrolysis when incorporated into an aqueous skin care composition.

Abstract: A skin care product is provided. The skin care product includes a multi-component skin care composition disposed in a multi-chamber container. The multi-component skin care composition includes an aqueous carrier component and a nicotinamide riboside component disposed in separate chambers, which prevents these components from contacting one another prior to use. The aqueous carrier component and the nicotinamide riboside component can be separated from one another by one or more fluid impermeable dividing members and/or activatable elements, which upon activation enable contact between the aqueous carrier component and nicotinamide riboside component.

Abstract: Cosmetic methods of increasing ARE activated gene transcription in a skin cell by contacting skin cells in a target portion of skin with an effective amount of niacinamide and nicotinamide riboside in combination to increase ARE activated gene transcription or synergistically increase ARE activated gene transcription of at least some of the skin cells contacted with the niacinamide and nicotinamide riboside. The cosmetic methods also enable synergistic reduction of ROS-induced adenosine triphosphate (ATP) depletion in a skin cell and restoration of glycolytic ATP production rate in a skin cell that has been reduced as a result of ROS-induced oxidative stress.

Abstract: A cosmetic method for reducing the level of High-Mobility Group Protein B1 released from keratinocytes. The method includes identifying a target portion of skin where reduction of HMGB1 level is desired, and topically applying a nicotinamide riboside containing cosmetic composition to the target portion of skin during a treatment period, which is sufficient to reduce the level of HMGB1 released by keratinocytes. By reducing HMGB1 protein level, melanocyte dendricity can be reduced, thereby resulting in less melanin being taken into keratinocytes. The reduction in melanin transfer may provide a way to treat skin pigmentation disorders such as hyperpigmented spots.

Abstract: A method of identifying or evaluating synergistic combinations of actives such as skin-care actives that improve the metabolism of a cell and provides an advantage over using the actives alone. The method includes contacting cells with test agents, alone and in combination, and determining a response of the cells to the test agent(s), wherein the response corresponds to a change in a metabolic indicator associated with glycolysis and a change in a metabolic indicator associated with oxidative phosphylation.

Abstract: A method of identifying or evaluating skin-care actives that improve the metabolism of a skin cell. The method includes contacting cells with a stressor and a test agent and determining a response of the cells to the stressor and test agent, based on the change in metabolic indicators associated with glycolysis and/or oxidative phosphylation. The test agent may be identified as a skin-care active when the oxidative phosphorylation and/or glycolysis response corresponds to an improvement in cellular metabolism.

Abstract: Cosmetic compositions for alleviating the signs of photoaged skin containing a substituted azole. Methods for alleviating the signs of photoaged skin that include applying a cosmetic composition comprising substituted azole to a target UV-exposed skin surface. The substituted azole compound present in the cosmetic composition may be 1-phenylimidazole, 4-phenylimidazole or a combination thereof. An effective amount of the cosmetic composition is applied to the target skin surface for a period of time sufficient to alleviate at least one sign of photoaging.

Abstract: Methods of improving the appearance of aging skin that include applying a cosmetic composition to a target skin surface having one or more signs of aging. The cosmetic composition includes a substituted azole. In some instances, the substituted azole compound is 1-phenylimidazole, 4-phenylimidazole, or combinations thereof. An effective amount of the cosmetic composition is applied for a period of time sufficient to improve the appearance of at least one sign of aging skin.