Patents by Inventor John Fruehauf

John Fruehauf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and Reagents for Preparing and Using Immunological Agents Specific for P-Glycoprotein
    Publication number: 20090280508
    Abstract: This invention relates to immunological reagents and methods specific for a mammalian, transmembrane protein termed Pgp, having a non-specific efflux pump activity established in the art as being a component of clinically-important multidrug resistance in cancer patients undergoing chemotherapy. The invention provides methods for developing and using immunological reagents specific for certain mutant forms of Pgp and for wild-type Pgp in a conformation associated with substrate binding or in the presence of ATP depleting agents. The invention also provides improved methods for identifying and characterizing anticancer compounds.
    Type: Application
    Filed: December 5, 2006
    Publication date: November 12, 2009
    Applicant: ONCOTECH, INC.
    Inventors: Eugene Mechetner, John Fruehauf
  • Methods for cancer prognosis and diagnosis
    Patent number: 7282346
    Abstract: The invention provides methods for prognosis, diagnosis, staging and disease progression in human cancer patients related to expression levels of a variety of immunohistochemical and genetic markers associated with poor cancer prognosis, and in particular those markers related to tumor invasiveness, metastasis and spread. The invention also provides methods using a predictive index for prognosis of cancer patients for metastasis, recurrence and relapse of neoplastic disease. The methods of the invention are useful for making clinical decisions on cancer treatment, surveillance and surgical intervention.
    Type: Grant
    Filed: October 16, 2001
    Date of Patent: October 16, 2007
    Assignee: Oncotech, Inc.
    Inventor: John Fruehauf
  • Methods and reagents for preparing and using immunological agents specific for P-glycoprotein
    Patent number: 7144704
    Abstract: This invention relates to immunological reagents and methods specific for a mammalian, transmembrane protein termed Pgp, having a non-specific efflux pump activity established in the art as being a component of clinically-important multidrug resistance in cancer patients undergoing chemotherapy. The invention provides methods for developing and using immunological reagents specific for certain mutant forms of Pgp and for wild-type Pgp in a conformation associated with substrate binding or in the presence of ATP depleting agents. The invention also provides improved methods for identifying and characterizing anticancer compounds.
    Type: Grant
    Filed: April 2, 2002
    Date of Patent: December 5, 2006
    Assignee: Oncotech, Inc.
    Inventors: Eugene Mechetner, John Fruehauf
  • METHODS AND REAGENTS FOR PREPARING AND USING IMMUNOLOGICAL AGENTS SPECIFIC FOR P-GLYCOPROTEIN
    Publication number: 20060211051
    Abstract: This invention relates to immunological reagents and methods specific for a mammalian, transmembrane protein termed Pgp, having a non-specific efflux pump activity established in the art as being a component of clinically-important multidrug resistance in cancer patients undergoing chemotherapy. The invention provides methods for developing and using immunological reagents specific for certain mutant forms of Pgp and for wild-type Pgp in a conformation associated with substrate binding or in the presence of ATP depleting agents. The invention also provides improved methods for identifying and characterizing anticancer compounds.
    Type: Application
    Filed: April 2, 2002
    Publication date: September 21, 2006
    Inventors: Eugene Mechetner, John Fruehauf
  • Methods for cancer prognosis and diagnosis
    Patent number: 6511806
    Abstract: The invention provides methods for prognosis, diagnosis, staging and disease progression in human cancer patients related to expression levels of a plurality of genes that are differentially expressed in chemotherapeutic drug resistant and drug sensitive tumor cells.
    Type: Grant
    Filed: November 3, 2000
    Date of Patent: January 28, 2003
    Assignee: Oncotech, Inc.
    Inventors: John Fruehauf, Eugene Mechetner
  • Methods for cancer prognosis and diagnosis
    Publication number: 20020039754
    Abstract: The invention provides methods for prognosis, diagnosis, staging and disease progression in human cancer patients related to expression levels of a variety of immunohistochemical and genetic markers associated with poor cancer prognosis, and in particular those markers related to tumor invasiveness, metastasis and spread. The invention also provides methods using a predictive index for prognosis of cancer patients for metastasis, recurrence and relapse of neoplastic disease. The methods of the invention are useful for making clinical decisions on cancer treatment, surveillance and surgical intervention.
    Type: Application
    Filed: October 16, 2001
    Publication date: April 4, 2002
    Applicant: Oncotech, Inc.
    Inventor: John Fruehauf
  • Methods and reagents for preparing and using immunological agents specific for P-glycoprotein
    Patent number: 6365357
    Abstract: This invention relates to immunological reagents and methods specific for a mammalian, transmembrane protein termed Pgp, having a non-specific efflux pump activity established in the art as being a component of clinically-important multidrug resistance in cancer patients undergoing chemotherapy. The invention provides methods for developing and using immunological reagents specific for certain mutant forms of Pgp and for wild-type Pgp in a conformation associated with substrate binding or in the presence of ATP depleting agents. The invention also provides improved methods for identifying and characterizing anticancer compounds.
    Type: Grant
    Filed: May 21, 1999
    Date of Patent: April 2, 2002
    Assignee: Onotech, Inc.
    Inventors: Eugene Mechetner, John Fruehauf
  • Methods for cancer prognosis and diagnosis
    Patent number: 6303324
    Abstract: The invention provides methods for prognosis, diagnosis, staging and disease progression in human cancer patients related to expression levels of a variety of immunohistochemical and genetic markers associated with poor cancer prognosis, and in particular those markers related to tumor invasiveness, metastasis and spread. The invention also provides methods using a predictive index for prognosis of cancer patients for metastasis, recurrence and relapse of neoplastic disease. The methods of the invention are useful for making clinical decisions on cancer treatment, surveillance and surgical intervention.
    Type: Grant
    Filed: November 24, 1998
    Date of Patent: October 16, 2001
    Assignee: Oncotech, Inc.
    Inventor: John Fruehauf
  • Methods for cancer prognosis and diagnosis
    Patent number: 5840507
    Abstract: The invention provides methods for prognosis, diagnosis, staging and disease progression in human cancer patients related to expression levels of a variety of immunohistochemical and genetic markers associated with poor cancer prognosis, and in particular those markers related to tumor invasiveness, metastasis and spread. The invention also provides methods using a predictive index for prognosis of cancer patients for metastasis, recurrence and relapse of neoplastic disease. The methods of the invention are useful for making clinical decisions on cancer treatment, surveillance and surgical intervention.
    Type: Grant
    Filed: April 11, 1997
    Date of Patent: November 24, 1998
    Assignee: Oncotech, Inc.
    Inventor: John Fruehauf