Patents by Inventor John G. MacConnell

John G. MacConnell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cholesterol lowering compound
    Patent number: 5468771
    Abstract: A compound of structural formula ##STR1## having antihypercholesterolemic utility is produced by culturing a Streptomyces sp.
    Type: Grant
    Filed: February 2, 1994
    Date of Patent: November 21, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Magda M. Gagliardi, Shieh-Shung T. Chen, Byron H. Arison, George M. Garrity, Leeyuan Huang, John G. MacConnell, Raymond F. White
  • Chemical compounds
    Patent number: 5362752
    Abstract: New cholesterol lowering compounds are formed from the photochemical treatment of zaragozic acid A.
    Type: Grant
    Filed: May 17, 1993
    Date of Patent: November 8, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Byron H. Arison, Gregory D. Berger, Leeyuan Huang, John G. MacConnell
  • Cholesterol lowering compounds
    Patent number: 5359096
    Abstract: New cholesterol lowering compounds are formed from the photochemical treatment of the zaragozic acids.
    Type: Grant
    Filed: November 20, 1992
    Date of Patent: October 25, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Laszlo R. Treiber, Byron H. Arison, Shieh-Shung T. Chen, George A. Doss, Leeyuan Huang, John G. MacConnell
  • Cholesterol lowering compounds
    Patent number: 5317031
    Abstract: Cholesterol lowering compounds and compositions are formed from the photochemical treatment of the Zaragozic Acids followed by esterification. These compounds and compositions are active squalene synthetase inhibitors useful in the treatment of hypercholesterolemia.
    Type: Grant
    Filed: November 24, 1992
    Date of Patent: May 31, 1994
    Assignee: Merck & Co., Inc.
    Inventors: John G. MacConnell, Byron H. Arison, George A. Doss, Richard L. Monaghan
  • Cholesterol lowering compounds produced by directed biosynthesis
    Patent number: 5302604
    Abstract: Compounds of Structural Formula (I) ##STR1## are produced by directed biosynthesis. These compounds are squalene synthetase inhibitors and thus useful as cholesterol lowering agents, antifungal agents and cancer treatment agents.
    Type: Grant
    Filed: October 6, 1992
    Date of Patent: April 12, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Kevin M. Byrne, Shieh-Shung T. Chen, Louis Kaplan, John G. MacConnell, Brian R. Petuch, Raymond F. White, Byron H. Arison
  • Cholesteral lowering agents
    Patent number: 5270332
    Abstract: This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthase inhibitors and thus useful as cholesterol lowering agents. The compounds also exhibit antifungal activity and are inhibitors of farnesyl-protein transferase.
    Type: Grant
    Filed: August 21, 1992
    Date of Patent: December 14, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Shieh-Shung T. Chen, Leeyuan Huang, John G. MacConnell, Jon D. Polishook, Raymond F. White
  • 23-Keto derivatives of C-076 compounds
    Patent number: 4289760
    Abstract: Derivatives of C-076 compounds are described in which the C-076 molecule, a series of macrolides, has the 23-hydroxy group thereof oxidized to the 23-keto group. The 23-keto compounds are prepared by selectively oxidizing the suitably protected 23-hydroxy compound using such oxidizing agents as pyridinium dichromate, chromic acid-dimethyl pyrazole, chromic acid, chromic acid-acetic acid, and the like. Alternatively, selective oxidation of the unprotected 23-hydroxy compound may be accomplished by placing the compound in soil. Further reaction of the oxidized C-076 compounds is also possible. The compounds thus produced have profound anthelmintic, insecticidal, ectoparasiticidal, and acaricidal activity. Compositions containing the described C-076 derivatives as the active ingredient thereof are also disclosed.
    Type: Grant
    Filed: May 2, 1980
    Date of Patent: September 15, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Helmut H. Mrozik, John G. MacConnell, August J. Kempf