Patents by Inventor John H. Griffin

John H. Griffin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for diagnosis of thrombotic disorders
    Patent number: 5705395
    Abstract: The present invention provides an in vitro method useful for the diagnosis of a thrombotic disorder in a subject, having or at risk of having the disorder. Specifically, the disorder exemplified herein is associated with APC resistant Factor V and Va. The clotting time of a test sample is analyzed in the presence and absence of APC and compared with a standard reference sample in order to diagnose the subject.
    Type: Grant
    Filed: November 14, 1994
    Date of Patent: January 6, 1998
    Assignees: The Scripps Research Institute, The Regents of the University of California
    Inventors: John H. Griffin, Samuel I. Rapaport, Dzung T. Le
  • Serine protease derived-polypeptides and anti-peptide antibodies, systems and therapeutic methods for inhibiting coagulation
    Patent number: 5679639
    Abstract: The present invention describes polypeptides and anti-peptide antibodies capable of inhibiting serine protease enzymatic activity. In particular, polypeptides and anti-peptide antibodies derived from the blood coagulation serine proteases Factor VIIa, Factor IXa, Factor Xa, Factor XIa, thrombin and plasma kallikrein are described that are capable of inhibiting coagulation. The polypeptide and antibody are useful in methods and systems for inhibiting serine proteases, and particularly for inhibiting blood coagulation processes mediated by serine proteases in vitro or in a human patient.
    Type: Grant
    Filed: August 22, 1994
    Date of Patent: October 21, 1997
    Assignee: The Scripps Research Institute
    Inventors: John H. Griffin, Rolf M. Mesters
  • Recombinant protein S variants deficient in C4BP binding activity, compositions and therapeutic methods
    Patent number: 5405946
    Abstract: The present invention describes a variant protein S protein that is substantially homologous in amino acid residue sequence to wild-type mature human protein S, which has in vitro anticoagulant activity and has a reduced ability to bind C4b binding protein (C4BP), compositions containing the variant protein S, and recombinant DNA vectors for expressing the variant protein. Also disclosed are therapeutic methods of using variant protein S for inhibiting thrombosis, inflammation and the like conditions ameliorated by protein S.
    Type: Grant
    Filed: December 2, 1992
    Date of Patent: April 11, 1995
    Assignee: The Scripps Research Institute
    Inventors: John H. Griffin, Bonno N. Bouma, Rogier Bertina
  • Inhibition of arterial thrombotic occlusion or thromboembolism
    Patent number: 5350578
    Abstract: The method of preventing arterial thrombotic occlusion or thromboembolism by administering plasma-derived or recombinant produced protein C alone or in combination with a thrombolytic agent or combinations of thrombolytic agents.
    Type: Grant
    Filed: October 25, 1991
    Date of Patent: September 27, 1994
    Assignee: Scripps Clinic and Research Foundation
    Inventors: John H. Griffin, Andras Gruber, Stephen R. Hanson, Lawrence A. Harker
  • Protein S polypeptides and anti-peptide antibodies that inhibit protein S binding to C4B binding protein, diagnostic systems and therapeutic methods
    Patent number: 5321123
    Abstract: The invention describes protein S polypeptides and anti-PS antibodies capable of inhibiting the binding of proteins to C4BP. The peptides and antibodies are useful in diagnostic methods and systems for purifying or detecting free protein S. In addition, the polypeptides are useful in therapeutic methods as an anti-coagulant.
    Type: Grant
    Filed: July 1, 1992
    Date of Patent: June 14, 1994
    Assignee: The Scripps Research Institute
    Inventors: John H. Griffin, Jose A. Fernandez
  • Assay methods for detecting serum proteases, particularly activated protein C
    Patent number: 5288612
    Abstract: The invention describes diagnostic methods and compositions for determining the amount of protease in a body fluid sample. In particular, the invention detects proteases by a method in which both a reversible inhibitor of the protease and an irreversible inhibitor of interfering proteases during the detection step are employed to increase the sensitivity of the enzyme capture assay. The assay detects normal serum levels of activated protein C.
    Type: Grant
    Filed: July 3, 1991
    Date of Patent: February 22, 1994
    Assignee: The Scripps Research Institute
    Inventors: John H. Griffin, Andras Gruber
  • Activated protein C polypeptides and anti-peptide antibodies, diagnostic methods and systems for inhibiting activated protein C
    Patent number: 5279956
    Abstract: The present invention describes APC polypeptides and anti-peptide antibodies capable of inhibiting activated Protein C anticoagulant activity. The polypeptide and antibody are useful in diagnostic methods and systems for measuring APC in vascular fluid samples. In addition, the polypeptide and anti-peptide antibody are useful in therapeutic methods for inhibiting APC in a human patient.
    Type: Grant
    Filed: June 24, 1991
    Date of Patent: January 18, 1994
    Assignee: The Scripps Research Institute
    Inventors: John H. Griffin, Rolf M. Mesters
  • Inhibition of arterial thrombotic occlusion or thromboembolism
    Patent number: 5084274
    Abstract: The method of preventing arterial thrombotic occulsion or thromboembolism by administering plasma-derived or recombinate produced protein C alone or in combination with a thrombolytic agent or combinations of thrombolytic agents.
    Type: Grant
    Filed: November 17, 1987
    Date of Patent: January 28, 1992
    Assignee: Scripps Clinic and Research Foundation
    Inventors: John H. Griffin, Andras Gruber, Stephen R. Hanson, Lawrence A. Harker