Patents by Inventor John H. Growdon

John H. Growdon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of identifying agents which regulate release of amyloid precursor protein
    Patent number: 6329155
    Abstract: Amyloid precursor protein (APP) processing which is activated by cell-surface neurotransmitter receptors, is described. An assay for testing an agent for the capacity to regulate, and particularly to stimulate, secretion of amyloid precursor protein (APP), a description of the characteristics of agents identified by the assay, and a method of altering APP processing in an individual are also disclosed. The assay, agents, and method of altering APP processing are particularly useful for the treatment and prevention of diseases involving APP processing, such as Alzheimer's disease.
    Type: Grant
    Filed: April 15, 1994
    Date of Patent: December 11, 2001
    Assignee: Massachusetts Institute of Technology
    Inventors: Roger M. Nitsch, Barbara E. Slack, Richard J. Wurtman, John H. Growdon
  • Antemortem diagnostic test for Alzheimer's disease
    Patent number: 5631168
    Abstract: An antemortem diagnostic test for neurodegenerative disease, particularly Alzheimer's disease, is disclosed. The method of the invention involves the collection of a sample of bodily fluid; the analysis of the concentration of neuronal membrane phospholipids and phospholipid metabolites, or the ratio of a phospholipid to its metabolite, in the sample; and the correlation of the concentration or the ratio to the corresponding value from control samples. The method can be used to determine the presence or the possibility that an individual can develop a neurodegenerative disease, such as Alzheimer's disease; to follow the course of neurodegenerative disease in an individual; and to validate the efficacy of a drug used to treat a neurodegenerative disease.
    Type: Grant
    Filed: December 12, 1994
    Date of Patent: May 20, 1997
    Assignee: Massachusetts Institute of Technology
    Inventors: John H. Growdon, Roger M. Nitsch, Richard J. Wurtman
  • Process and composition for treating disorders by administering amphetamine and choline
    Patent number: 4636494
    Abstract: Choline or a natural or synthetic compound that dissociates to form choline is administered to a patient concomitantly with a drug in order to potentiate the effect of the drug by increasing acetylcholine levels in the brain or other tissues, and/or to suppress, or block the development of, unwanted side effects of the drug, by increasing acetylcholine levels in the brain or other tissues.
    Type: Grant
    Filed: March 17, 1982
    Date of Patent: January 13, 1987
    Assignee: Massachusetts Institute of Technology
    Inventors: John H. Growdon, Richard J. Wurtman
  • Cytidyl diphosphocholine-drug composition and process
    Patent number: 4609647
    Abstract: Cytidyl diphosphocholine is administered to a patient alone to increase brain acetylcholine levels or concomitantly with a drug in order to potentiate the effect of the drug by increasing acetylcholine levels in the brain or other tissues, and/or to suppress, or block the development of, unwanted side effects of the drug, by increasing acetylcholine levels in the brain or other tissues.
    Type: Grant
    Filed: October 9, 1985
    Date of Patent: September 2, 1986
    Assignee: Massachusetts Institute of Technology
    Inventors: John H. Growdon, Richard J. Wurtman
  • Cytidyl diphosphocholine-drug composition
    Patent number: 4569929
    Abstract: Cytidyl diphosphocholine is administered to a patient alone to increase brain acetylcholine levels or concomitantly with a drug in order to potentiate the effect of the drug by increasing acetylcholine levels in the brain or other tissues, and/or to suppress, or block the development of, unwanted side effects of the drug, by increasing acetylcholine levels in the brain or other tissues.
    Type: Grant
    Filed: December 22, 1983
    Date of Patent: February 11, 1986
    Assignee: Massachusetts Institute of Technology
    Inventors: John H. Growdon, Richard J. Wurtman
  • Process and composition for treating disorders by administering a butyrophenone and a choline
    Patent number: 4456598
    Abstract: Choline or a natural or synthetic compound that dissociates to form choline is administered to a patient concomitantly with a drug in order to potentiate the effect of the drug by increasing acetylcholine levels in the brain or other tissues, and/or to suppress, or block the development of, unwanted side effects of the drug, by increasing acetylcholine levels in the brain or other tissues.
    Type: Grant
    Filed: May 3, 1982
    Date of Patent: June 26, 1984
    Assignee: Massachusetts Institute of Technology
    Inventors: John H. Growdon, Richard J. Wurtman
  • Process and composition for treating disorders by administering a phenothiazine and choline
    Patent number: 4430330
    Abstract: Choline or a natural or synthetic compound that dissociates to form choline is administered to a patient concomitantly with a drug in order to potentiate the effect of the drug by increasing acetylcholine levels in the brain or other tissues, and/or to suppress, or block the development of, unwanted side effects of the drug, by increasing acetylcholine levels in the brain or other tissues.
    Type: Grant
    Filed: April 8, 1982
    Date of Patent: February 7, 1984
    Assignee: Massachusetts Institute of Technology
    Inventors: John H. Growdon, Richard J. Wurtman
  • Process and composition for treating disorders by administering piracetam and choline
    Patent number: 4355027
    Abstract: Choline or a natural or synthetic compound that dissociates to form choline is administered to a patient concomitantly with piracetam [(oxo-2-pyrrolidinyl-) 2 acetamine] in order to potentiate the effect of the drug by increasing acetylcholine levels in the brain or other tissues, and/or to suppress, or block the development of, unwanted side effects of the drug, by increasing acetylcholine levels in the brain or other tissues.
    Type: Grant
    Filed: July 20, 1981
    Date of Patent: October 19, 1982
    Assignee: Massachusetts Institute of Technology
    Inventors: John H. Growdon, Richard J. Wurtman
  • Process and composition for treating disorders by administering isoxsurpine and choline
    Patent number: 4351831
    Abstract: Choline or a natural or synthetic compound that dissociates to form choline is administered to a patient concomitantly with a drug in order to potentiate the effect of the drug by increasing acetylcholine levels in the brain or other tissues, and/or to suppress, or block the development of, unwanted side effects of the drug, by increasing acetylcholine levels in the brain or other tissues.
    Type: Grant
    Filed: January 30, 1981
    Date of Patent: September 28, 1982
    Assignee: Massachusetts Institute of Technology
    Inventors: John H. Growdon, Richard J. Wurtman
  • Process and composition for treating disorders by administering lithium and choline
    Patent number: 4346084
    Abstract: Choline or a natural or synthetic compound that dissociates to form choline is administered to a patient concomitantly with a drug in order to potentiate the effect of the drug by increasing acetylcholine levels in the brain or other tissues, and/or to suppress, or block the development of, unwanted side effects of the drug, by increasing acetylcholine levels in the brain or other tissues.
    Type: Grant
    Filed: January 30, 1981
    Date of Patent: August 24, 1982
    Assignee: Massachusetts Institute of Technology
    Inventors: John H. Growdon, Richard J. Wurtman
  • Process and composition for treating disorders by administering amphetamine and choline
    Patent number: 4346085
    Abstract: Choline or a natural or synthetic compound that dissociates to form choline is administered to a patient concomitantly with a drug in order to potentiate the effect of the drug by increasing acetylcholine levels in the brain or other tissues, and/or to suppress, or block the development of, unwanted side effects of the drug, by increasing acetylcholine levels in the brain or other tissues.
    Type: Grant
    Filed: January 30, 1981
    Date of Patent: August 24, 1982
    Assignee: Massachusetts Institute of Technology
    Inventors: John H. Growdon, Richard J. Wurtman
  • Process and composition for treating disorders by administering lecithin
    Patent number: 4221784
    Abstract: Lecithin without a drug is administered to a patient in order to increase acetylcholine levels in the brain or other tissues, thereby to alleviate the effects of tardive dykinesia, manic-depressive disease, memory impairment or familial ataxias.
    Type: Grant
    Filed: April 5, 1979
    Date of Patent: September 9, 1980
    Assignee: Massachusetts Institute of Technology
    Inventors: John H. Growdon, Richard J. Wurtman