Patents by Inventor John H. Lawrence, III

John H. Lawrence, III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gene delivery compositions and methods
    Patent number: 7256182
    Abstract: The present provides methods and compositions that enable effective delivery of nucleic acids to desired cells, including to a solid organ such as a mammalian heart. The methods and compositions enable effective gene transfer and subsequent expression to a majority of cells throughout a solid organ such as the heart. Methods and compositions of the invention preferably provide enhanced vascular permeability that enables increased gene transfer to targeted cells, but without significant degradation or injury to endothelial cell layers. Global delivery of nucleic acid to an intact heart has been achieved with as little as 2 minutes of intracoronary exposure to the administered nucleic acid.
    Type: Grant
    Filed: December 9, 2004
    Date of Patent: August 14, 2007
    Assignee: Johns Hopkins University
    Inventors: John H. Lawrence, III, J. Kevin Donahue
  • Gene delivery compositions and methods
    Patent number: 6855701
    Abstract: The present provides methods and compositions that enable effective delivery of nucleic acids to desired cells, including to a solid organ such as a mammalian heart. The methods and compositions enable effective gene transfer and subsequent expression to a majority of cells throughout a solid organ such as the heart. Methods and compositions of the invention preferably provide enhanced vascular permeability that enables increased gene transfer to targeted cells, but without significant degradation or injury to endothelial cell layers. Global delivery of nucleic acid to an intact heart has been achieved with as little as 2 minutes of intracoronary exposure to the administered nucleic acid.
    Type: Grant
    Filed: March 5, 2002
    Date of Patent: February 15, 2005
    Assignee: The Johns Hopkins University
    Inventors: John H. Lawrence, III, J. Kevin Donahue
  • Gene delivery compositions and methods
    Patent number: 6376471
    Abstract: The present provides methods and compositions that enable effective delivery of nucleic acids to desired cells, including to a solid organ such as a mammalian heart. The methods and compositions enable effective gene transfer and subsequent expression to a majority of cells throughout a solid organ such as the heart. Methods and compositions of the invention preferably provide enhanced vascular permeability that enables increased gene transfer to targeted cells, but without significant degradation or injury to endothelial cell layers. Global delivery of nucleic acid to an intact heart has been achieved with as little as 2 minutes of intracoronary exposure to the administered nucleic acid.
    Type: Grant
    Filed: October 8, 1998
    Date of Patent: April 23, 2002
    Assignee: Johns Hopkins University
    Inventors: John H. Lawrence, III, J. Kevin Donahue