Abstract: Disclosed herein are recombinant meganucleases engineered to bind and cleave a recognition sequence in the mitochondrial DNA (mtDNA) of a eukaryotic cell, such as a plant cell. The disclosure further relates to the use of such recombinant meganucleases in methods for producing genetically-modified eukaryotic cells, and to a population of genetically-modified eukaryotic cells wherein the mtDNA has been having modified or edited.

Abstract: A device and system for purifying a fluid is provided. The system includes a tank having an interior space and a media container disposed within the interior space. A valve is provided that cooperates with an element within the interior, the valve being movable between an open and a closed position. The valve being biased to the open position when the element is not positioned within the interior space, wherein the interior space is fluidly coupled to the atmosphere in the open position. The valve further being configured to move to a closed position when the element is positioned within the interior space.

Abstract: A neuromodulation therapy is delivered via at least one electrode implanted subcutaneously and superficially to a fascia layer superficial to a nerve of a patient. In one example, an implantable medical device is deployed along a superficial surface of a deep fascia tissue layer superficial to a nerve of a patient. Electrical stimulation energy is delivered to the nerve through the deep fascia tissue layer via implantable medical device electrodes.

Abstract: A neuromodulation therapy is delivered via at least one electrode implanted subcutaneously and superficially to a fascia layer superficial to a nerve of a patient. In one example, an implantable medical device is deployed along a superficial surface of a deep fascia tissue layer superficial to a nerve of a patient. Electrical stimulation energy is delivered to the nerve through the deep fascia tissue layer via implantable medical device electrodes.

Abstract: A therapy system includes a patient support apparatus and a pneumatic therapy device that is coupleable to the patient support apparatus. The therapy device may receive power and air flow from the patient support apparatus.

Abstract: A device and system for purifying a fluid is provided. The system includes a tank having an interior space and a media container disposed within the interior space. A valve is provided that cooperates with an element within the interior, the valve being movable between an open and a closed position. The valve being biased to the open position when the element is not positioned within the interior space, wherein the interior space is fluidly coupled to the atmosphere in the open position. The valve further being configured to move to a closed position when the element is positioned within the interior space.

Abstract: Systems and methods for allocating computing resources for a multi-tiered application are disclosed. A computer-implemented method includes: determining, by a computing device, a topology of a multi-tiered application; determining, by the computing device, a modeled setting of a computing resource for the multi-tiered application based on the determined topology; determining, by the computing device, an actual usage of the computing resource by the multi-tiered application; and adjusting, by the computing device, an allocation of the computing resource to the multi-tiered application based on the actual usage and the modeled setting.

Abstract: Systems and methods for allocating computing resources for a multi-tiered application are disclosed. A computer-implemented method includes: determining, by a computing device, a topology of a multi-tiered application; determining, by the computing device, a modeled setting of a computing resource for the multi-tiered application based on the determined topology; determining, by the computing device, an actual usage of the computing resource by the multi-tiered application; and adjusting, by the computing device, an allocation of the computing resource to the multi-tiered application based on the actual usage and the modeled setting.

Abstract: Systems and methods for allocating computing resources for a multi-tiered application are disclosed. A computer-implemented method includes: determining, by a computing device, a topology of a multi-tiered application; determining, by the computing device, a modeled setting of a computing resource for the multi-tiered application based on the determined topology; determining, by the computing device, an actual usage of the computing resource by the multi-tiered application; and adjusting, by the computing device, an allocation of the computing resource to the multi-tiered application based on the actual usage and the modeled setting.

Abstract: Systems and methods for allocating computing resources for a multi-tiered application are disclosed. A computer-implemented method includes: determining, by a computing device, a topology of a multi-tiered application; determining, by the computing device, a modeled setting of a computing resource for the multi-tiered application based on the determined topology; determining, by the computing device, an actual usage of the computing resource by the multi-tiered application; and adjusting, by the computing device, an allocation of the computing resource to the multi-tiered application based on the actual usage and the modeled setting.

Abstract: A memory utilization value indicative of memory utilization associated with a data channel is received. A queue depth value indicative of the queue depth of messages located within a message queue maintained by the data channel is also received. A fuzzy logic design is executed with the memory utilization value in the queue depth value used as input parameters. A crisp value is then generated which corresponds to a window size of the data channel.

Abstract: A hose reel stand having a reel and hub assembly which is rotatable about the vertical axis of the hose reel stand, allowing a hose supported on the reel to be easily dispensed from any direction. The hub is rotatably attached and supported on a post so as to be vertically adjustable. A flow control unit including a valve and flow timer are also attached to the post below the reel and hub assembly. The flow control unit allows complete control of the water flow to the hose so as to provide a complete watering station remote from a water source. The hose reel stand is designed to be permanently anchored to the ground.

Abstract: A fuel assembly fabrication apparatus includes a stationary support fixture and a slide fixture mounted to one end portion thereof for movement therealong. Clamp structures are disposed in spaced relation longitudinally along the stationary support fixture. One clamp structure is mounted on the movable slide fixture and supports a top nozzle and an uppermost one of a plurality of grids of a fuel assembly. The remaining clamp structures are mounted on the stationary support fixture and support a bottom nozzle and the remaining grids. The clamp structures respectively support the top nozzle and uppermost grid and the bottom nozzle and remaining grids in generally parallel relationship with passageways defined in the top and bottom nozzles and sleeves connected on the grids being aligned for slidably receiving therethrough a plurality of guide thimbles and an instrumentation tube of the fuel assembly for attachment to the nozzles and grid sleeves.

Abstract: A one-step loading adapter is attached to a lifting truck. The adapter is able to transport and position a store such as a missile from a storage location to an aircraft wing for mounting thereto without transfer to another device. The adapter has a removable boom assembly for lifting and lowering the store as desired. An adjustable cradle having three degrees of freedom is able to position the store for mounting once the store is loaded thereon.

Abstract: A device for loading granular material containing some foreign matter into a container, such as a railroad car, has upper and lower chutes arranged in parallel. The upper chute has a bottom screen for allowing the foreign matter to fall through to the lower chute. The grain flow remaining on the upper chute is discharged down the center of the car and fills toward the sides, while the foreign matter falling to the lower chute is distributed evenly by sidewardly extending wings out toward the sides and in towards the center of the car. By the operation of the device, the foreign matter carried in the grain is evenly distributed and mixed throughout the car, and the tendency of the foreign matter to concentrate along the center under the hatchway of the car is prevented. A sample of the grain taken from the hatchway of the car thereby contains a truer percentage of foreign matter to grain than would occur by conventional loading devices.

Abstract: An individual nuclear fuel rod weighing system for rods carried on a tray which moves along a materials handling conveyor. At a first tray position on the conveyor, a lifting device raises the rods off the tray and places them on an overhead ramp. A loading mechanism conveys the rods singly from the overhead ramp onto an overhead scale for individual weighing. When the tray is at a second position on the conveyor, a transfer apparatus transports each weighed rod from the scale back onto the tray.

Abstract: Delayed petroleum coke is calcined in an internally-fired vertical shaft kiln. A downwardly-moving bed of green coke is preheated in the top of the kiln by rising combustion gases, then heat soaked at calcining temperatures in the intermediate section of the kiln, and finally cooled by recycle gas moving upwardly from the lower part of the kiln. Partially cooled calcined coke is recovered from the bottom of the kiln.