Abstract: The present disclosure relates to IL-34 antibodies, compositions comprising the same, and methods of using the antibodies and or compositions thereof for treating immune-mediated diseases such as neurodegenerative diseases, for example Alzheimer's Disease or a tauopathy disease.

Abstract: A fenestration system includes a chassis formed from left and right chassis stiles, and top and bottom chassis rails. The left and right chassis stiles having an outside longitudinal groove, an outside longitudinal ridge, an inside longitudinal groove and an inside longitudinal ridge. The top and bottom chassis rails having an outside longitudinal groove, an outside longitudinal ridge, an inside longitudinal groove and an inside longitudinal ridge. Outside stile covers are configured to engage the longitudinal outside groove and the longitudinal outside ridge of the chassis stile. Inside stile covers are configured to engage the inside longitudinal groove and the inside longitudinal ridge of the chassis stile. Outside rail covers are configured to engage the longitudinal outside groove and the longitudinal outside ridge of the chassis rail. Inside rail covers are configured to engage the inside longitudinal groove and the inside longitudinal ridge of the chassis rail.

Abstract: A fenestration system includes a chassis formed from left and right chassis stiles, and top and bottom chassis rails. The left and right chassis stiles having an outside longitudinal groove, an outside longitudinal ridge, an inside longitudinal groove and an inside longitudinal ridge. The top and bottom chassis rails having an outside longitudinal groove, an outside longitudinal ridge, an inside longitudinal groove and an inside longitudinal ridge. Outside stile covers are configured to engage the longitudinal outside groove and the longitudinal outside ridge of the chassis stile. Inside stile covers are configured to engage the inside longitudinal groove and the inside longitudinal ridge of the chassis stile. Outside rail covers are configured to engage the longitudinal outside groove and the longitudinal outside ridge of the chassis rail. Inside rail covers are configured to engage the inside longitudinal groove and the inside longitudinal ridge of the chassis rail.

Abstract: A fenestration system includes a chassis formed from left and right chassis stiles, and top and bottom chassis rails. The left and right chassis stiles having an outside longitudinal groove, an outside longitudinal ridge, an inside longitudinal groove and an inside longitudinal ridge. The top and bottom chassis rails having an outside longitudinal groove, an outside longitudinal ridge, an inside longitudinal groove and an inside longitudinal ridge. Outside stile covers are configured to engage the longitudinal outside groove and the longitudinal outside ridge of the chassis stile. Inside stile covers are configured to engage the inside longitudinal groove and the inside longitudinal ridge of the chassis stile. Outside rail covers are configured to engage the longitudinal outside groove and the longitudinal outside ridge of the chassis rail. Inside rail covers are configured to engage the inside longitudinal groove and the inside longitudinal ridge of the chassis rail.

Abstract: A fenestration system includes a chassis formed from left and right chassis stiles, and top and bottom chassis rails. The left and right chassis stiles having an outside longitudinal groove, an outside longitudinal ridge, an inside longitudinal groove and an inside longitudinal ridge. The top and bottom chassis rails having an outside longitudinal groove, an outside longitudinal ridge, an inside longitudinal groove and an inside longitudinal ridge. Outside stile covers are configured to engage the longitudinal outside groove and the longitudinal outside ridge of the chassis stile. Inside stile covers are configured to engage the inside longitudinal groove and the inside longitudinal ridge of the chassis stile. Outside rail covers are configured to engage the longitudinal outside groove and the longitudinal outside ridge of the chassis rail. Inside rail covers are configured to engage the inside longitudinal groove and the inside longitudinal ridge of the chassis rail.

Abstract: Provided is a fenestration kit comprising a vinyl based welded fenestration chassis and chassis covers for covering the chassis inside surface, outside surface, or both. The kit may be a window sash frame kit, a door panel frame kit, a window frame kit, or a door frame kit. These kits will be referred to generally as fenestration frame kits. The chassis covers are provided with stops which cooperate with corresponding stops on the chassis frame to prevent relative longitudinal movement between the covers and the chassis. The chassis covers are provided with engagement members which cooperate with corresponding engagement members provided on the chassis to connect the covers to the chassis.

Abstract: Provided is a fenestration kit comprising a vinyl based welded fenestration chassis and chassis covers for covering the chassis inside surface, outside surface, or both. The kit may be a window sash frame kit, a door panel frame kit, a window frame kit, or a door frame kit. These kits will be referred to generally as fenestration frame kits. The chassis covers are provided with stops which cooperate with corresponding stops on the chassis frame to prevent relative longitudinal movement between the covers and the chassis. The chassis covers are provided with engagement members which cooperate with corresponding engagement members provided on the chassis to connect the covers to the chassis.

Abstract: A window assembly comprising a window frame and a window sash is disclosed. The sash is supported on the window frame for pivotal movement between an open position and a closed position. The sash supports an insulated glass unit with an internal blind and includes a primary operator connected to the blind so that linear movement of the primary operator causes movement of said blind. When the sash is closed, a secondary operator supported in the window frame engages the primary operator so that linear movement of the secondary operator causes a corresponding linear movement of the primary operator.

Abstract: A window assembly comprising a window frame and a window sash is disclosed. The sash is supported on the window frame for pivotal movement between an open position and a closed position. The sash supports an insulated glass unit with an internal blind and includes a primary operator connected to the blind so that linear movement of the primary operator causes movement of said blind. When the sash is closed, a secondary operator supported in the window frame engages the primary operator so that linear movement of the secondary operator causes a corresponding linear movement of the primary operator.

Abstract: Chemotactin, diethyl phthalate, is shown to be a chemoattractant secreted by H. pylori. Chemotactin attracts phagocytic cells with a resulting inflammatory episode. Chemotactin and its metabolites may be used for diagnosis and monitoring courses of infection by H. pylori or other chemotactin secreting organisms. In addition, chemotactin may be used in research for studying the inflammatory process, for identifying new drugs for modulating chemoattraction and activation of phagocytic cells, and for inducing an inflammatory response as a therapeutic intervention.