Patents by Inventor John Hagan
John Hagan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11964844Abstract: A fish tape case is configured to house a fish tape. The fish tape includes a shell having an upper base wall, a lower base wall, an inner side wall extending between inner perimeters of the base walls and forming a central aperture through the shell, an outer side wall extending between outer perimeters of the base walls and defining an outer diameter of the shell, the walls defining a cavity therein, the upper base wall having a first opening therethrough in communication with the cavity through which the fish tape can exit, and the outer side wall having a second opening therethrough in communication with the cavity through which the fish tape can exit. A storage reel is mounted in the cavity for holding the fish tape.Type: GrantFiled: September 11, 2020Date of Patent: April 23, 2024Assignee: GREENLEE TOOLS, INC.Inventors: John Wayne Kroening, James Donald Schmidt, Greg Sassi, John Hagan
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Patent number: 11859247Abstract: The invention relates to constructs comprising a transmembrane protein pore subunit and a nucleic acid handling enzyme. The pore subunit is covalently attached to the enzyme such that both the subunit and enzyme retain their activity. The constructs can be used to generate transmembrane protein pores having a nucleic acid handling enzyme attached thereto. Such pores are particularly useful for sequencing nucleic acids. The enzyme handles the nucleic acid in such a way that the pore can detect its component nucleotides by stochastic sensing.Type: GrantFiled: June 23, 2021Date of Patent: January 2, 2024Assignee: Oxford Nanopore Technologies PLCInventors: Lakmal Jayasinghe, John Hagan Pryce Bayley, Stephen Cheley, Brian McKeown, James White, James Clarke
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Publication number: 20230270715Abstract: Disclosed here are uses of autophagy inhibitors for treating a subject at risk of suffering from an aneurysm. The present disclosure demonstrates that autophagy plays a role in THSD1-mediated focal adhesion stability and aneurysm formation and characterizes molecular targets for therapeutic intervention.Type: ApplicationFiled: May 25, 2022Publication date: August 31, 2023Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventors: Dong H. Kim, Yanning Rui, Zhen Xu, John Hagan
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Publication number: 20230213553Abstract: End launch termination devices are shown and disclosed. In one embodiment, the device includes a housing, a first clamp fixedly attached to the housing, and a second clamp opposed to the first clamp and movably attached to at least one of the first clamp or the housing, the first and second clamps defining a gap therebetween to receive a test substrate. The device additionally includes a conductor received in the cavity and fixedly attached to the housing, a center pin attached to the conductor and extending into the gap, and a rod resistor received in the cavity, attached to the conductor, and extending out of the housing.Type: ApplicationFiled: January 3, 2023Publication date: July 6, 2023Applicant: Krytar, Inc.Inventors: Douglas John Hagan, Michael Romero
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Publication number: 20230212522Abstract: The disclosure describes global transcriptome profiling in human vascular endothelial cells upon THSD1 knockdown and identification from these studies of specific genes and pathways that are THSD1. The analysis highlights a role for THSD1 in regulating endothelial to mesenchymal transition and other pathways. The analysis also demonstrates that endothelial cell injury is the first event of an intracranial aneurysm. The disclosure provides novel cell lines and reagents used for better understanding the molecular mechanism of THSD1 biology.Type: ApplicationFiled: May 25, 2022Publication date: July 6, 2023Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventors: Dong H. Kim, Yuanqing Yan, Yanning Rui, Zhen Xu, John Hagan
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Publication number: 20230210858Abstract: Disclosed here are uses of anti-podosome therapies for treating a subject at risk of suffering from an aneurysm. The present disclosure demonstrates that endothelial podosomes plays a role in THSD1-mediated focal adhesion stability and aneurysm formation and characterizes molecular targets for therapeutic intervention.Type: ApplicationFiled: May 25, 2022Publication date: July 6, 2023Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventors: Dong H. Kim, Zhen Xu, Yanning Rui, John Hagan
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Publication number: 20230212246Abstract: Disclosed here are metal coils conjugated to TGF-beta ligand(s) or TGF-beta activator(s) to improve the outcome of existing surgical treatments on intracranial aneurysm patients and methods for using the same.Type: ApplicationFiled: May 25, 2022Publication date: July 6, 2023Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventors: Dong H. Kim, Zhen Xu, Yanning Rui, John Hagan
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Publication number: 20230193181Abstract: The invention relates to an apparatus for producing a droplet assembly, which apparatus comprises: at least one droplet generator suitable for generating droplets of a viscous droplet medium; a droplet receiving region which is moveable relative to the at least one droplet generator; a temperature controller; and a control unit, which control unit is adapted to control the dispensing of droplets from the at least one droplet generator and the movement of the droplet receiving region relative to the at least one droplet generator, wherein the apparatus is adapted to produce a droplet assembly in the droplet receiving region, wherein the droplet assembly comprises a plurality of droplets, wherein each of said droplets comprises (i) a droplet medium, and (ii) an outer layer of amphipathic molecules around the surface of the droplet medium.Type: ApplicationFiled: May 20, 2021Publication date: June 22, 2023Inventors: John Hagan Pryce Bayley, Linna Zhou
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Patent number: 11673762Abstract: A fish tape case is configured to house a fish tape in accordance with some example embodiments is provided. The fish tape includes a shell having a rotatable tray therein. A fish tape extends through openings in the shell and the tray. The fish tape case does not include a handle.Type: GrantFiled: May 26, 2022Date of Patent: June 13, 2023Assignee: GREENLEE TOOLS, INC.Inventors: Janine Victoria Mazur, William Nordlin, John Hagan, John Wayne Kroening
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Publication number: 20230115014Abstract: A hand-held conduit bending tool includes an elongated handle and a bender head disposed on the handle. The bender head comprising a body portion having at least one curved channel therein. In an embodiment, the channel is elliptical in cross-section. A handle mount is at a rear end of the body portion and rearward of the hook portion and a foot pedal is formed. In some embodiments, two channels are provided to accommodate two differently sized conduits. Markings are provided to enable use of the tool in a head-down position and in a head-up position.Type: ApplicationFiled: November 22, 2021Publication date: April 13, 2023Inventors: John Wayne Kroening, Sachin Shashikant Dakare, Andrew Francis Troy, Katey Earley, Rahul Maruti Nanche, Jae Kwang Lee, John Hagan
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Patent number: 11624047Abstract: The invention provides a process for producing a gel network, which gel network comprises a plurality of joined gel objects, which process comprises: forming a plurality of gel objects in one or more microfluidic channels; dispensing the gel objects from the one or more microfluidic channels into a region for producing the network; and contacting each gel object with at least one other gel object in said region to join each gel object to at least one other gel object at a region of contact between the gel objects. The invention also provides a network of joined gel objects, comprising a plurality of gel objects, wherein each gel object is joined to an adjacent gel object at a region of contact between the gel objects. Also provided are various possible uses of the gel network.Type: GrantFiled: June 2, 2017Date of Patent: April 11, 2023Assignee: Oxford University Innovation LimitedInventors: John Hagan Pryce Bayley, Shaohua Ma
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Patent number: 11592382Abstract: The invention relates to a new method of determining the presence, absence, number or position(s) of one or more post-translational modifications in a peptide, polypeptide or protein. The invention uses transmembrane pores.Type: GrantFiled: May 27, 2020Date of Patent: February 28, 2023Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: John Hagan Pryce Bayley, David Rodriguez-Larrea, Christian Bech Rosen
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Publication number: 20230048266Abstract: The invention provides a droplet encapsulate comprising: a drop of a hydrophobic medium; a peripheral layer of non-polymeric amphipathic molecules around the surface of the drop; and an aqueous droplet within the peripheral layer, the aqueous droplet comprising: (a) an aqueous medium and (b) an outer layer of non-polymeric amphipathic molecules around the surface of the aqueous medium. The invention also provides processes for preparing the droplet encapsulates. Various uses of the droplet encapsulates are also described, including their use as drug delivery vehicles, in synthetic biology, and in the study of membrane proteins.Type: ApplicationFiled: June 29, 2022Publication date: February 16, 2023Inventors: John Hagan Pryce Bayley, Andrew Heron, Gabriel Villar
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Publication number: 20220289519Abstract: A fish tape case is configured to house a fish tape. The fish tape includes a shell having an upper base wall, a lower base wall, an inner side wall extending between inner perimeters of the base walls and forming a central aperture through the shell, an outer side wall extending between outer perimeters of the base walls and defining an outer diameter of the shell, the walls defining a cavity therein, the upper base wall having a first opening therethrough in communication with the cavity through which the fish tape can exit, and the outer side wall having a second opening therethrough in communication with the cavity through which the fish tape can exit. A storage reel is mounted in the cavity for holding the fish tape.Type: ApplicationFiled: September 11, 2020Publication date: September 15, 2022Inventors: John Wayne Kroening, James Donald Schmidt, Greg Sassi, John Hagan
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Publication number: 20220281711Abstract: A fish tape case is configured to house a fish tape in accordance with some example embodiments is provided. The fish tape includes a shell having a rotatable tray therein. A fish tape extends through openings in the shell and the tray. The fish tape case does not include a handle.Type: ApplicationFiled: May 26, 2022Publication date: September 8, 2022Inventors: JANINE VICTORIA MAZUR, WILLIAM NORDLIN, JOHN HAGAN, JOHN WAYNE KROENING
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Patent number: 11406603Abstract: The invention provides a droplet encapsulate comprising: a drop of a hydrophobic medium; a peripheral layer of non-polymeric amphipathic molecules around the surface of the drop; and an aqueous droplet within the peripheral layer, the aqueous droplet comprising: (a) an aqueous medium and (b) an outer layer of non-polymeric amphipathic molecules around the surface of the aqueous medium. The invention also provides processes for preparing the droplet encapsulates. Various uses of the droplet encapsulates are also described, including their use as drug delivery vehicles, in synthetic biology, and in the study of membrane proteins.Type: GrantFiled: December 19, 2019Date of Patent: August 9, 2022Assignee: Oxford University Innovation LimitedInventors: John Hagan Pryce Bayley, Andrew Heron, Gabriel Villar
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Patent number: 11365085Abstract: An ergonomic fish tape configured to house a fish tape in accordance with some example embodiments is provided. The fish tape includes a shell having an upper base wall, a lower base wall, an inner side wall extending between inner perimeters of the base walls and forming a central aperture through the shell, an outer side wall extending between outer perimeters of the base walls and defining an outer diameter of the shell, the walls defining a cavity therein, and a storage tray within the cavity. An opening through which the fish tape can pass is provided through the outer side wall. The fish tape case does not include a handle, and the walls of the shell are devoid of surfaces which would indicate or suggest to a user as to how to grip the fish tape case.Type: GrantFiled: May 8, 2020Date of Patent: June 21, 2022Assignee: Greenlee Tools, Inc.Inventors: Janine Victoria Mazur, William Nordlin, John Hagan, John Wayne Kroening
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Patent number: 11304903Abstract: The invention provides a compartmentalised gel matrix comprising one or more compartments, wherein each compartment comprises a volume of hydrophobic medium and one or more aqueous droplets therein. The invention further provides a pharmaceutical formulation comprising a compartmentalised gel matrix according to the invention, a synthetic cell comprising a compartmentalised gel matrix according to the invention and a synthetic tissue comprising a compartmentalised gel matrix according to the invention.Type: GrantFiled: March 27, 2018Date of Patent: April 19, 2022Assignees: Oxford University Innovation Limited, Katholieke Universiteit LeuvenInventors: John Hagan Pryce Bayley, Kunwar Tanuj Sapra, Giovanni Maglia, Mariam Mohamed Abdelsattar Bayoumi
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Publication number: 20220089406Abstract: An ergonomic fish tape configured to house a fish tape in accordance with some example embodiments is provided. The fish tape includes a shell having an upper base wall, a lower base wall, an inner side wall extending between inner perimeters of the base walls and forming a central aperture through the shell, an outer side wall extending between outer perimeters of the base walls and defining an outer diameter of the shell, the walls defining a cavity therein, and a storage tray within the cavity. An opening through which the fish tape can pass is provided through the outer side wall. The fish tape case does not include a handle, and the walls of the shell are devoid of surfaces which would indicate or suggest to a user as to how to grip the fish tape case.Type: ApplicationFiled: May 8, 2020Publication date: March 24, 2022Inventors: Janine Victoria Mazur, William Nordlin, John Hagan, John Wayne Kroening
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Publication number: 20220072497Abstract: The invention relates to an apparatus for producing a droplet assembly, which apparatus comprises a droplet generator. A process for producing a droplet assembly, using an apparatus comprising a droplet generator is also described. The invention also relates to droplet assemblies comprising a plurality of droplets. Various uses of the droplet assemblies are also described.Type: ApplicationFiled: November 17, 2021Publication date: March 10, 2022Inventors: John Hagan Pryce Bayley, Gabriel Villar, Alexander D. Graham