Abstract: The present invention relates to an intranasal pharmaceutical dosage form comprising a dosing unit comprising naloxone or a pharmaceutically acceptable salt thereof in an amount of equivalent to ?0.5 mg naloxone HCl dissolved in an application fluid of a volume of ?250 ?l. Furthermore, the present invention relates to such an intranasal pharmaceutical dosage form for use in the treatment of opioid overdosing and/or at least one symptom thereof.

Abstract: Described herein are battery modules and methods of fabricating thereof. In some examples, a battery module comprises an enclosure, separated into two enclosure portions and a thermal portion, positioned between the two enclosure portions. Two enclosure portions are in part defined by side walls, which can be tapered. The thermal portion comprises two thermal walls, which are operable as the bottoms of the two enclosure portions and form a thermal cavity between these thermal walls. In some examples, the enclosure is a monolithically cast component. Alternatively, the enclosure can be partially cast with one thermal wall welded thereafter to a cast subassembly. The battery module also comprises two sets of batteries, each positioned into a corresponding enclosure portion. Each battery set is interconnected with an interconnecting assembly, positioned between the battery set and the corresponding cover, for this enclosure portion.

Abstract: Described herein are battery packs and electric vehicles using these packs. In some examples, a battery pack comprises two portions/covers and a set of battery modules positioned within the enclosed cavity formed by these portions. A battery pack may comprise a set of pressure-relief valves positioned in and protruding through a wall of at least one portion. Each valve can be coaxial with a corresponding gap provided between two adjacent modules. The valve is configured to provide a fluid path (to the exterior of the battery pack) when the pressure inside the pack exceeds a set threshold. In some examples, the battery pack comprises an inlet tube fluidically coupled to the inlet port of each module and an outlet tube fluidically coupled to the outlet port of each module. A set of specially configured orifices or controllable valves is positioned on the fluid path through each module.

Abstract: A method for producing a neutrons includes triggering a raising or a lowering of a temperature of a pyroelectric crystal of less than about 40° C. to produce a voltage of negative polarity of at least ?100 keV on a surface of a deuterated or tritiated target coupled thereto. A deuterium ion source is pulsed to produce a deuterium ion beam. The accelerating of the deuterium ion beam is achieved by accelerating voltage of the pyroelectric crystal toward the deuterated or tritiated target to produce neutrons. Furthermore, the pyroelectric crystal, the deuterated or tritiated target, and the deuterium ion source are coupled to a common support. The method also includes throwing the common support housing the pyroelectric crystal, the deuterated or tritiated target, and the deuterium ion source near an unknown threat for identification thereof.

Abstract: Methods, computer-readable media, software, and apparatuses are provided to assist a user and vendor in completing an online trusted transaction. Trusted vendor websites are verified and user identities are confirmed through a cyber-security safe logon credentialing system. The vendor can be confident that the user identity has been verified to be who they say they are and the user can be confident that they are using a trusted verified vendor website.

Abstract: Methods and systems for coupling gas and water supply tubes to a container. An illustrative container and tube set may comprise a container configured to contain a fluid, the container having a bottom portion and a top portion, a water supply tube including a first end, a second end, and a first lumen, a gas supply tube including a first end, a second end, and a second lumen, and a weight coupled to the first end of the water supply tube and a first end of the gas supply tube. The first lumen may be in selective fluid communication with the bottom portion of the container and the second end of the water supply tube positioned external to the container. The second lumen may be in operative fluid communication with the container and the second end of the gas supply tube is positioned external to the container.

Abstract: While a vehicle is in a minimal power state, a first sensor is activated based on a location of the vehicle within a monitored area. The vehicle is transitioned to an on state based on detecting an object via data from the first sensor. Then the vehicle is operated to block an exit from the monitored area based on identifying the object as an unauthorized object.

Abstract: A charge level of a sensor battery providing power to a sensor in a vehicle is determined. A charge depletion of the sensor battery is determined based on the charge level. A recharge rate to recharge the sensor battery is determined based on a time elapsed on a previously traveled path, a current charge level, and the charge depletion. Upon activation of the vehicle, one or both of a propulsion or a vehicle battery is actuated to recharge the sensor battery at the recharge rate.

Abstract: Radiopharmaceutical compounds of general Formula (I) are based on a sarcophagine cage having a PEG linker-group X through to a group Y capable of binding to a biological receptor and an albumin-binding group Z for the treatment, diagnosis or imaging of diseases including cancer, and the production of such compounds and their complexes.

Abstract: An apparatus may be configured to: determine an anticipated change in a transmit power of a cell, wherein the apparatus is connected to a network via the cell; perform one or more measurements related to the cell; modify the one or more measurements based, at least partially, on the anticipated change in the transmit power of the cell; and transmit a measurement report in response to the anticipated change in the transmit power of the cell, wherein the measurement report is based, at least partially, on the one or more modified measurements. An apparatus may be configured to: determine to change a transmit power to a user equipment for a first cell; transmit, to the user equipment, at least one message; initiate the change in the transmit power over a time period; and receive, from the user equipment, a measurement report in response to the at least one message.

Abstract: An actuator module includes a base plate extending in a plane, a voice coil connected to the base plate, and a magnet assembly that includes a back side facing the base plate and a front side facing away from the base plate. The magnet assembly includes a base layer and sidewalls defining a cup and an inner element including a center magnet mounted within the cup. The sidewalls include a first and second pair of sidewalls. The actuator module includes a rigid frame attached to the base plate, the rigid frame including four stubs.

Abstract: An actuator module includes a base plate extending in a plane, a voice coil connected to the base plate, and a magnet assembly that includes a back side facing the base plate and a front side facing away from the base plate. The magnet assembly includes a base layer and sidewalls defining a cup and an inner element including a center magnet mounted within the cup. The sidewalls include a first and second pair of sidewalls. The actuator module includes a rigid frame attached to the base plate, the rigid frame including four stubs. The actuator module also includes a plurality of springs suspending the magnet assembly relative to the frame and base plate, the plurality of springs including a first spring attached to the frame at a first pair of the four stubs and a second spring attached to the frame at a second pair of the four stubs.

Abstract: A method for producing a neutrons includes producing a voltage of negative polarity of at least ?100 keV on a surface of a deuterated or tritiated target in response to a temperature change of a pyroelectric crystal of less than about 40° C., the pyroelectric crystal having the deuterated or tritiated target coupled thereto, pulsing a deuterium ion source to produce a deuterium ion beam, accelerating the deuterium ion beam to the deuterated or tritiated target, and directing the ion beam onto the deuterated or tritiated target to make neutrons using at least one element of the following: a voltage of the pyroelectric crystal and a high gradient insulator (HGI) surrounding the pyroelectric crystal. The accelerating of the deuterium ion beam is achieved by using an ion accelerating mechanism comprising a pyroelectric stack accelerator having a first thermal altering mechanism for changing a temperature of the pyroelectric stack accelerator.

Abstract: A blade for use in a gas turbine engine, the blade comprising a blade portion and a fir tree root portion, the blade portion and the root portion having a connected passage for allowing cooling air to flow within the blade, the fir tree root portion having an air intake on its leading edge, the air intake allowing cooling air to enter the cooling passage and wherein the fir tree root portion comprises a plurality of projections, including at least a base projection and a top projection; and wherein the air inlet located in the base projection of the fir tree root portion and wherein the air inlet comprises at least 50% of the face of the base projection of the fir tree root portion.

Abstract: An actuator module includes a base plate extending in a plane, a voice coil connected to the base plate, and a magnet assembly that includes a back side facing the base plate and a front side facing away from the base plate. The magnet assembly includes a base layer and sidewalls defining a cup and an inner element including a center magnet mounted within the cup. The sidewalls include a first and second pair of sidewalls. The actuator module includes a rigid frame attached to the base plate, the rigid frame including four stubs. The actuator module also includes a plurality of springs suspending the magnet assembly relative to the frame and base plate, the plurality of springs including a first spring attached to the frame at a first pair of the four stubs and a second spring attached to the frame at a second pair of the four stubs.

Abstract: Aqueous formulations and kits of radiopharmaceutical compounds of general Formula (II) protected from radiolysis with stabilisers, such as L-methionine and gentisic acid, are disclosed, wherein the compounds are based on sarcophagine ligands coordinated to a radioisotope, such as 64-copper, and linked to a tetrazine group for reaction with tumour targeting antibodies having functional reactive groups such as trans-cyclooctene, processes of preparing said radioligand formulations, and uses thereof for radioimaging, diagnosing and treating cancer.

Abstract: A variety of thermoplastic parts are provided with precise micro-scale features and long-range macro-scale reproducibility. By combining the advantages of rigid tool molding and soft tooling into a hybrid tooling, complex and challenging microfeatures can be created in thermoplastic parts with remarkable positional accuracy and reproducibility. The parts described herein can demonstrate orders of magnitude smaller inter-part variations and order of magnitude smaller variations with respect to a master part as compared to conventional hard and soft tooling methods. In some aspects, a plurality of thermoplastic parts having precision micro-scale features and reproducible macro-scale dimensions are provided wherein the precision micro-scale features on each part comprise at least one challenging microfeature; and wherein a mean normalized displacement of the micro-scale features is about or less when measured between the parts in the plurality of thermoplastic parts.

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for computer aided design of physical structures using generative design processes. A method includes obtaining one or more load cases and one or more design criteria for a modeled object, the one or more design criteria comprising a build material strength model indicating strength relationships between thickness of an object feature and build angle for that object feature resulting from additive manufacturing; iteratively modifying a three dimensional shape of the modeled object in accordance with the one or more design criteria and the one or more load cases, including applying the strength relationships between the thickness of the object feature and the build angle for that object feature on a per-element basis during numerical simulation of the modeled object; and providing the three dimensional shape of the modeled object for use in manufacturing a physical structure.

Abstract: A method of deliquification of production wells includes placing an artificial lift tool in a gas wellbore, where the artificial lift tool includes a rack and multiple piezoelectric transducers. The rack includes multiple trays. Each piezoelectric transducer of the multiple piezoelectric transducers is positioned on a respective tray of the multiple trays. The method further includes providing, by a pump, a liquid on surfaces of the multiple piezoelectric transducers and providing, by a signal source, an electrical signal to the multiple piezoelectric transducers. The method also includes generating, by the multiple piezoelectric transducers, acoustic waves from the electrical signal, where at least some of the liquid provided to the multiple piezoelectric transducers is atomized by the acoustic waves.