Abstract: This invention relates to novel compounds having the structural formula I below: and their pharmaceutically acceptable salts, tautomers or in vivo-hydrolysable precursors, compositions and methods of use thereof, wherein R1, R2, R3, R4, R5, and R6 are defined in the specification. These novel compounds provide a treatment or prophylaxis of anxiety disorders, schizophrenia, cognitive disorders, and/or mood disorders.

Abstract: This invention relates to novel compounds having formula (I) to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit secretase and thereby inhibit the production of amyloid ? protein, thereby acting to prevent the formation of neurological deposits of amyloid protein.

Abstract: A railway car and indicator operable to show the status of at least one component of an associated discharge control system. The railway car may have at least one hopper for transporting lading. A respective door assembly may be mounted adjacent to a discharge opening formed proximate a lower portion of the hopper to control the flow of lading from the hopper. The discharge control system may move each door assembly between a first position and a second position relative to the discharge opening. The indicator may extend from at least one side of the railway car to indicate the status of the at least one component of the associated discharge control system.

Abstract: A remote controlled robot system that includes a mobile robot and a remote control station. A user can control movement of the robot from the remote control station. The mobile robot includes a camera system that can capture and transmit to the remote station a zoom image and a non-zoom image. The remote control station includes a monitor that displays a robot view field. The robot view field can display the non-zoom image. The zoom image can be displayed in the robot view field by highlighting an area of the non-zoom field. The remote control station may also store camera locations that allow a user to move the camera system to preset locations.

Abstract: A railcar with discharge control system is disclosed. In one embodiment, a railway car includes an underframe and at least one hopper for transporting lading. The railway car further including the underframe including a center sill which defines in part a longitudinal axis of the railway car. A discharge opening formed proximate to a lower portion of the hopper. A respective door assembly pivotally mounted adjacent to the discharge opening to control the flow of lading from the hopper. The door assembly operable for movement between a first, closed position and a second, open position relative to the discharge opening. A discharge control system operable to move the door assembly between the first position and the second position. The discharge control system operably moves generally longitudinally along the axis of the railway car to move the door assemblies between the first, closed position and the second, open position.

Abstract: A safety latch lock indicator for a railcar door operation mechanism is disclosed. In one aspect, the present invention teaches a railway car having an underframe and at least one hopper for transporting lading. The underframe including a center sill which defines in part a longitudinal axis of the railway car. A respective door assembly mounted adjacent to the discharge opening formed proximate to a lower portion of the hopper to control the flow of lading from the hopper. The door assembly moves via the discharge control system between a first and second position relative to the discharge opening. An indicator may extend from a side of the railway car as the door assembly moves between the first and second positions, wherein a portion of the indicator becomes visible from at least one side of the railway car.

Abstract: A railcar with discharge control system is disclosed. In one embodiment, a railway car includes an underframe and at least one hopper for transporting lading. The railway car further including the underframe including a center sill which defines in part a longitudinal axis of the railway car. A discharge opening formed proximate to a lower portion of the hopper. A respective door assembly pivotally mounted adjacent to the discharge opening to control the flow of lading from the hopper. The door assembly operable for movement between a first, closed position and a second, open position relative to the discharge opening. A discharge control system operable to move the door assembly between the first position and the second position. The discharge control system operably moves generally longitudinally along the axis of the railway car to move the door assemblies between the first, closed position and the second, open position.

Abstract: A railcar with longitudinal discharge openings is disclosed. In one embodiment, the railcar includes an underframe, a pair of sidewall assemblies and a hopper formed between the sidewall assemblies. The underframe has a center sill and a pair of side sills. The center sill disposed between the pair of side sills along a generally longitudinally axis of the railcar. The hopper includes a discharge opening adjacent to the center sill. A respective discharge door assembly disposed adjacent to each discharge opening to control flow of lading from each hopper. Each discharge door may hinge from the center sill for movement between a first position and a second position relative to the discharge openings.

Abstract: Alpha-substituted pyridazino-quinoline compounds of formula Ia useful for the treatment of strokes and neurodegenerative disorders: wherein R1 is selected from a variety of substituents including halogen, (C1-C4)alkyl and nitro; R2 is selected from cycloalkyl moieties of 5-7 carbon atoms and the groups R2′ and R2″ as defined in the specification, a dashed bond indicates a single or double bond, and R7 is selected from H and CO(C1-C3)alkyl.

Abstract: Food products containing isoflavones and calcium are taught where the weight ratio of isoflavones to calcium is from 1 to 2 to 1 to 50.

Abstract: A food product containing isoflavones and flavanol is taught, where the weight ratio of isoflavones to flavanol is from 10 to 1 to 1 to 100.

Abstract: The invention relates to alpha-substituted pyridazino-quinoline compounds of the formula I: 1

Abstract: The invention relates to alpha-substituted pyridazino-quinoline compounds of the formula I: ##STR1## wherein Ring A is chosen from an ortho fused aromatic or heteroaromatic five- or six-membered ring; R.sup.1 is selected from a variety of substituents including halogen, (1-4C)alkyl and nitro; R.sup.2 is selected from a group of the formula R2', R2" or R2"' wherein R2' is --CHR.sup.3 (CH.sub.2).sub.n C(O)NR.sup.5 R.sup.6 ; R2" is --CHR.sup.3 (CH.sub.2).sub.n R.sup.4 and R2"' is --CHR.sup.3 (CH.sub.2).sub.n L wherein n is 0-6; R.sup.5 is aryl or substituted aryl; R.sup.6 is (1-6C)alkyl or hydrogen; R.sup.3 is (1-6C)alkyl, (0-6C)alkylCF.sub.3 or (0-6C)alkylCOOR'; R.sup.4 is (1-6C)alkyl, (2-6C)alkyl containing a double or triple bond, or (0-6C)alkylaryl; L is a variety of substituents including phenyl, heteroaryl and CO.sub.2 R'; R' is hydrogen or (1-4C)alkyl; Z is selected from oxo, --OH, H,H--, H, (1-6C)alkyl or (1-6C)alkylaryl; and R.sup.7 is hydrogen or --(CO)R.sup.8 wherein R.sup.