Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: A method and system for determining the authenticity of an item such as an original work of art, an art print, valuable jewelry or other valuable items utilizes images of one or more unique patterns of features, preferably at a microscopic level, as one or more "signatures" of the item. The image of this unique signature is recorded and stored electronically as data representing the unique pattern. The data are registered with identifying text and stored in a secure storage location, to prevent unauthorized duplication or use of the stored data. Following this registration and storage, an item presented as authentic can be examined microscopically at prescribed sites on the item where the original images were taken. Comparison is made at one or more of the sites, and a decision is made as to whether the item exhibits substantially identical features to those originally registered, so as to be the same authentic item. Comparison can be made electronically or visually/microscopically.

Abstract: A method and system for determining the authenticity of an item such as an original work of art, an art print, valuable jewelry or other valuable items utilizes images of one or more unique patterns of features, preferably at a microscopic level, as one or more "signatures" of the item. The image of this unique signature is recorded and stored electronically as data representing the unique pattern. The data are registered with identifying text and stored in a secure storage location, to prevent unauthorized duplication or use of the stored data. Following this registration and storage, an item presented as authentic can be examined microscopically at prescribed sites on the item where the original images were taken. Comparison is made at one or more of the sites, and a decision is made as to whether the item exhibits substantially identical features to those originally registered, so as to be the same authentic item. Comparison can be made electronically or visually/microscopically.

Abstract: An optical power splitter for the distribution of high-power light energy has a plurality of prisms arranged about a central axis to form a central channel. The input faces of the prisms are in a common plane which is substantially perpendicular to the central axis. A beam of light which is substantially coaxial to the central axis is incident on the prisms and at least partially strikes a surface area of each prism input face. The incident beam also partially passes through the central channel.

Abstract: An electromechanical chaotic chiming mechanism, analogous to the classical wind or water powered chime, includes a body or framework suspending a series of chimes with a pendulum suspended centrally among the chimes. A drive mechanism for the pendulum includes a permanent magnet on the pendulum and a drive electromagnet in a base positioned just below a centered rest position of the pendulum. With the electromagnet switched on and off, in a regular linear pattern, the electromagnetic drive causes a chime hammer on the pendulum to behave in a chaotic manner, sounding the chimes in a fashion virtually indistinguishable from natural meteorological forces acting on conventional windchimes. Variations can be made to the pattern or period of the drive electromagnet to vary the pattern of sound produced by the chimes.