Abstract: An apparatus enabling a user to perform a simulated bicycling exercise includes a frame, two mounting points defining an axis, the two mounting points comprising an upper rear mounting point comprising an upper rear rotating joint and a lower front mounting point comprising a pivoting connection arrangement proximate to and interacting with the frame, the pivoting connection arrangement comprising at least one resistive element configured to provide resistive force returning the frame to a neutral centered orientation from an off-centered orientation and pedals associated with a wheel and the frame, the pedals enabling the user, when facing forward, to apply force to the pedals and rotate the wheel. The frame is configured to receive forces from the user and dissipate the forces into frame leaning forces such that the user has an ability to cause the frame to pivot about the two mounting points by leaning to one side.

Abstract: An apparatus enabling a user to perform a simulated bicycling exercise includes a frame, two mounting points defining an axis, the two mounting points comprising an upper rear mounting point comprising an upper rear rotating joint and a lower front mounting point comprising a pivoting connection arrangement proximate to and interacting with the frame, the pivoting connection arrangement comprising at least one resistive element configured to provide resistive force returning the frame to a neutral centered orientation from an off-centered orientation and pedals associated with a wheel and the frame, the pedals enabling the user, when facing forward, to apply force to the pedals and rotate the wheel. The frame is configured to receive forces from the user and dissipate the forces into frame leaning forces such that the user has an ability to cause the frame to pivot about the two mounting points by leaning to one side.

Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The apparatus includes a frame, a first upper rear mounting point and a second lower front mounting point configured to maintain the frame, the first upper rear mounting point having an upper rear movable rotating joint, a seat connected to the frame and configured to support the user in a forward facing orientation, a wheel positioned in association with the frame, a set of pedals configured to interact with the wheel, a stem passing through the head tube, and a connection arrangement connecting the stem to a base. The frame is configured to pivot about the first upper rear mounting point and second lower front mounting point in response to leaning by the user, causing rotation of the stem by the connection arrangement.

Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The apparatus includes a frame, a first upper rear mounting point and a second lower front mounting point configured to maintain the frame, the first upper rear mounting point having an upper rear movable rotating joint, a seat connected to the frame and configured to support the user in a forward facing orientation, a wheel positioned in association with the frame, a set of pedals configured to interact with the wheel, a stem passing through the head tube, and a connection arrangement connecting the stem to a base. The frame is configured to pivot about the first upper rear mounting point and second lower front mounting point in response to leaning by the user, causing rotation of the stem by the connection arrangement.

Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The apparatus includes a frame having a head tube, a first upper rear mounting point and a second lower front mounting point configured to maintain the frame, the first upper rear mounting point comprising an upper rear movable rotating joint, a seat connected to said frame and configured to support the user in a forward facing orientation, a wheel positioned in association with said frame, a set of pedals configured to interact with said wheel, and a stem connected to a handlebar arrangement, the stem passing through the head tube and connected to a base by a connection arrangement. The frame is configured to pivot about the first upper rear mounting point and second lower front mounting point in response to leaning by the user, causing rotation of the stem within the head tube.

Abstract: An apparatus and method permitting a user to perform traction of the back is provided. The design includes a seat bottom and seat back. The seat back is configured to pivot about the seat bottom enabling the seat back to recline while rotating away from the seat bottom. An adjustable strap is positioned in association with the seat back for the purpose of securing the user's upper body. An adjustable strap is positioned in association with the seat bottom for the purpose of securing the user's lower body, buttocks and hips. A leg rest may be provided to support the user's legs. A locking mechanism may be provided to permit the user to easily sit down, engage the lower body and upper body straps, release the locking mechanism and recline backwards from a seated to a supine position thereby providing traction and providing decompression of the of the spinal column.

Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The design includes a frame having a head tube, wherein the frame maintains a set of pedals, a first upper rear mounting point and a second lower front mounting point configured to maintain the frame, a seat connected to the frame configured to support the user, and a stem connected to a handlebar arrangement, passing through the head tube, and connected to a base by a connection arrangement. The frame is configured to pivot about the first upper rear mounting point and second lower front mounting point in response to leaning by the user causing movement of the connection arrangement and rotation of the stem. The connection arrangement is adjustable to vary amount of rotation of the stem within the head tube in response to leaning by the user.

Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The apparatus includes a frame having a head tube, a first upper rear mounting point and a second lower front mounting point configured to maintain the frame, the first upper rear mounting point comprising an upper rear movable rotating joint, a seat connected to said frame and configured to support the user in a forward facing orientation, a wheel positioned in association with said frame, a set of pedals configured to interact with said wheel, and a stem connected to a handlebar arrangement, the stem passing through the head tube and connected to a base by a connection arrangement. The frame is configured to pivot about the first upper rear mounting point and second lower front mounting point in response to leaning by the user, causing rotation of the stem within the head tube.

Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The design includes a frame having a head tube, wherein the frame maintains a set of pedals, a first upper rear mounting point and a second lower front mounting point configured to maintain the frame, a seat connected to the frame configured to support the user, and a stem connected to a handlebar arrangement, passing through the head tube, and connected to a base by a connection arrangement. The frame is configured to pivot about the first upper rear mounting point and second lower front mounting point in response to leaning by the user causing movement of the connection arrangement and rotation of the stem. The connection arrangement is adjustable to vary amount of rotation of the stem within the head tube in response to leaning by the user.

Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The design includes a base, a frame comprising a head tube, and a lower front pivoting point connected to the base and an upper rear pivoting axial member positioned a fixed distance above the base. The lower front pivoting point and the upper rear pivoting axial member include a multiple component resistive element arrangement and collectively defining an axis of rotation, the axis of rotation forming a fixed angle relative to the base of 30 to 45 degrees, sloping upward in a rearward direction from the front pivoting point to the upper rear pivoting axial member. The design further includes a stem connected to a handlebar arrangement, the stem passing through the head tube and connected to the base by a connection arrangement comprising an arm.

Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The design includes a frame having a head tube, a first upper rear mounting point and a second lower front mounting point configured to maintain the frame, and a stem connected to a handlebar arrangement, the stem passing through the headset collar and connected to a base by a connection arrangement comprising an arm. The frame is configured to pivot about the first upper rear mounting point and second lower front mounting point in response to leaning by the user, causing rotation of the stem within the head tube by movement of the connection arrangement.

Abstract: The invention provides a droplet actuator designed for performing electroporation on cells in droplets. The invention also provides method and systems for performing electroporation on cells in droplets on a droplet actuator.

Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The design includes a base, a frame comprising a head tube, and a lower front pivoting point connected to the base and an upper rear pivoting axial member positioned a fixed distance above the base. The lower front pivoting point and the upper rear pivoting axial member include a multiple component resistive element arrangement and collectively defining an axis of rotation, the axis of rotation forming a fixed angle relative to the base of 30 to 45 degrees, sloping upward in a rearward direction from the front pivoting point to the upper rear pivoting axial member. The design further includes a stem connected to a handlebar arrangement, the stem passing through the head tube and connected to the base by a connection arrangement comprising an arm.

Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The design includes a base, a frame comprising a head tube, and a lower front pivoting point connected to the base and an upper rear pivoting axial member positioned a fixed distance above the base. The lower front pivoting point and the upper rear pivoting axial member include a multiple component resistive element arrangement and collectively defining an axis of rotation, the axis of rotation forming a fixed angle relative to the base of 30 to 45 degrees, sloping upward in a rearward direction from the front pivoting point to the upper rear pivoting axial member. The design further includes a stem connected to a handlebar arrangement, the stem passing through the head tube and connected to the base by a connection arrangement comprising an arm.

Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The design includes a frame having a head tube, a first upper rear mounting point and a second lower front mounting point configured to maintain the frame, and a stem connected to a handlebar arrangement, the stem passing through the headset collar and connected to a base by a connection arrangement comprising an arm. The frame is configured to pivot about the first upper rear mounting point and second lower front mounting point in response to leaning by the user, causing rotation of the stem within the head tube by movement of the connection arrangement.

Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The design includes a frame having a head tube, a first upper rear mounting point and a second lower front mounting point configured to maintain the frame, a seat connected to said frame and configured to support the user in a forward facing orientation, a wheel positioned in association with said frame and pedals configured to interact with said wheel, and a stem connected to a handlebar arrangement, the stem passing through the headset collar and connected to a base by a connection arrangement comprising an arm. The frame is configured to pivot about the first upper rear mounting point and second lower front mounting point in response to leaning by the user, causing rotation of the stem within the head tube by movement of the connection arrangement comprising the arm.

Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The design includes a base, a frame comprising a head tube, and a lower front pivoting point connected to the base and an upper rear pivoting axial member positioned a fixed distance above the base. The lower front pivoting point and the upper rear pivoting axial member include a multiple component resistive element arrangement and collectively defining an axis of rotation, the axis of rotation forming a fixed angle relative to the base of 30 to 45 degrees, sloping upward in a rearward direction from the front pivoting point to the upper rear pivoting axial member. The design further includes a stem connected to a handlebar arrangement, the stem passing through the head tube and connected to the base by a connection arrangement comprising an arm.

Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The design includes a horizontal base, a lower front pivoting point, and user supporting hardware collectively adjoining pedals, a seat configured to support the user, and handlebars, the user supporting hardware provided above the horizontal base and interfacing with the lower front mounting point. The lower front pivoting point and the user supporting hardware include a multiple component resistive element arrangement and collectively define an axis of rotation forming an angle with the horizontal base of 30 to 45 degrees, sloping upward in a rearward direction from the front pivoting point to the user supporting hardware. When the user is seated on the seat and leans in one direction, such leaning causes the user supporting hardware, seat, and handlebars to rotate in the one direction about the axis of rotation.

Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The design includes a frame having a head tube, a first upper rear mounting point and a second lower front mounting point configured to maintain the frame, a seat connected to said frame and configured to support the user in a forward facing orientation, a wheel positioned in association with said frame and pedals configured to interact with said wheel, and a stem connected to a handlebar arrangement, the stem passing through the headset collar and connected to a base by a connection arrangement comprising an arm. The frame is configured to pivot about the first upper rear mounting point and second lower front mounting point in response to leaning by the user, causing rotation of the stem within the head tube by movement of the connection arrangement comprising the arm.

Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The design includes a frame and a first mounting point and a second mounting point configured to maintain the frame. A seat is connected to the frame and configured to support the user. A wheel is positioned in association with said frame and pedals configured to interact with the wheel, and the frame is configured to pivot about the first mounting point and second mounting point in response to leaning by the user. Handlebars may be provided that enable further force application and enhance the leaning or pivoting in the bicycle riding simulation experience.