Patents by Inventor John J. L. Simard
John J. L. Simard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8637305Abstract: The invention disclosed herein is directed to methods of identifying a polypeptide suitable for epitope liberation including, for example, the steps of identifying an epitope of interest; providing a substrate polypeptide sequence including the epitope, wherein the substrate polypeptide permits processing by a proteasome; contacting the substrate polypeptide with a composition including the proteasome, under conditions that support processing of the substrate polypeptide by the proteasome; and assaying for liberation of the epitope. The invention further relates to vectors including a housekeeping epitope expression cassette. The housekeeping epitope(s) can be derived from a target-associated antigen, and the housekeeping epitope can be liberatable, that is capable of liberation, from a translation product of the cassette by immunoproteasome processing. The invention also relates to a method of activating a T cell comprising contacting a substrate polypeptide with an APC and contacting the APC with a T cell.Type: GrantFiled: November 7, 2002Date of Patent: January 28, 2014Assignee: Mannkind CorporationInventors: John J. L. Simard, David C. Diamond, Zhiyong Qiu, Xiang-Dong Lei
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Patent number: 8372393Abstract: Disclosed herein are methods for inducing an immunological CTL response to an antigen by sustained, regular delivery of the antigen to a mammal so that the antigen reaches the lymphatic system. Antigen is delivered at a level sufficient to induce an immunologic CTL response in a mammal and the level of the antigen in the mammal's lymphatic system is maintained over time sufficient to maintain the immunologic CTL response. Also disclosed is an article of manufacture for delivering an antigen that induces a CTL response in an animal.Type: GrantFiled: May 3, 2006Date of Patent: February 12, 2013Assignee: Mannkind CorporationInventors: Thomas M. Kündig, John J. L. Simard
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Publication number: 20120258462Abstract: Disclosed herein are methods for matching a cancer condition with an appropriate immunotherapeutic agent and/or regimen. Also disclosed are methods for confirming diagnosis of a particular type of cancer. Embodiments of the invention disclosed herein are directed to the use of effective combinations of TuAAs to optimize the match between a patient's cancer condition and available immunotherapies.Type: ApplicationFiled: April 23, 2012Publication date: October 11, 2012Applicant: MANNKIND CORPORATIONInventors: Chih-Sheng CHIANG, John J.L. SIMARD
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Patent number: 8252916Abstract: The invention disclosed herein is directed to methods of identifying a polypeptide suitable for epitope liberation including, for example, the steps of identifying an epitope of interest; providing a substrate polypeptide sequence including the epitope, wherein the substrate polypeptide permits processing by a proteasome; contacting the substrate polypeptide with a composition including the proteasome, under conditions that support processing of the substrate polypeptide by the proteasome; and assaying for liberation of the epitope. The invention further relates to vectors including a housekeeping epitope expression cassette. The invention relates to epitope cluster regions and to vectors including epitope cluster regions. The invention also relates to a method of activating a T cell comprising contacting a substrate polypeptide with an APC and contacting the APC with a T cell.Type: GrantFiled: April 30, 2004Date of Patent: August 28, 2012Assignee: MannKind CorporationInventors: John J. L. Simard, David C. Diamond, Zhiyong Qiu, Xiang-Dong Lei
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Publication number: 20120046638Abstract: Disclosed herein are methods for inducing an immunological CTL response to an antigen by sustained, regular delivery of the antigen to a mammal so that the antigen reaches the lymphatic system. Antigen is delivered at a level sufficient to induce an immunologic CTL response in a mammal and the level of the antigen in the mammal's lymphatic system is maintained over time sufficient to maintain the immunologic CTL response. Also disclosed is an article of manufacture for delivering an antigen that induces a CTL response in an animal.Type: ApplicationFiled: May 3, 2006Publication date: February 23, 2012Inventors: Thomas M. Kundig, John J. L. Simard
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Publication number: 20120010384Abstract: Disclosed herein are vaccines and methods for inducing an immune response against cancer cells and cells infected with intracellular parasites. Vaccines having housekeeping epitopes are disclosed. The housekeeping epitope is formed by housekeeping proteasomes in peripheral cells, but not by professional antigen presenting cells. A vaccine containing a housekeeping epitope that is derived from an antigen associated with a peripheral target cell can thus direct an immune response against the target cell. Methods of treatment are also disclosed, which involve administering a vaccine having a housekeeping epitope.Type: ApplicationFiled: December 20, 2010Publication date: January 12, 2012Applicant: MANNKIND CORPORATIONInventors: John J.L. SIMARD, David C. Diamond
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Publication number: 20090285843Abstract: Disclosed herein are polypeptides, including epitopes, clusters, and antigens. Also disclosed are compositions that include said polypeptides and methods for their use.Type: ApplicationFiled: August 19, 2008Publication date: November 19, 2009Applicant: Mannkind CorporationInventors: John J. L. Simard, David C. Diamond, Liping Liu, Zheng Liu
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Publication number: 20090208537Abstract: Disclosed herein are immunogenic compositions, methods of designing immunogenic compositions, methods of treatment using immunogenic compositions, methods of evaluating cell-mediated immunity resulting from immunogenic compositions, research models, and methods of making research models, all of which relate to targeting tumor vasculature.Type: ApplicationFiled: July 2, 2007Publication date: August 20, 2009Applicant: MANNKIND CORPORATIONInventors: John J.L. Simard, David C. Diamond
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Publication number: 20090148478Abstract: Disclosed herein are methods and compositions for inducing an immune response against various combinations of tumor-associated antigens, which can promote effective immunologic intervention in pathogenic processes. Embodiments of the invention disclosed herein are directed to the use of effective combinations of TuAAs for the immunotherapy of patients with various types of cancer. Both immunogenic compositions for inducing an immune response to these combinations of antigens and methods for their use are disclosed.Type: ApplicationFiled: October 16, 2008Publication date: June 11, 2009Applicant: MANNKIND CORPORATIONInventors: Chih-Sheng CHIANG, Adrian Ion BOT, John J.L. SIMARD, David C. DIAMOND
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Publication number: 20090035252Abstract: Disclosed herein are methods for inducing an immunological CTL response to an antigen by sustained, regular delivery of the antigen to a mammal so that the antigen reaches the lymphatic system. Antigen is delivered at a level sufficient to induce an immunologic CTL response in a mammal and the level of the antigen in the mammal's lymphatic system is maintained over time sufficient to maintain the immunologic CTL response. Also disclosed is an article of manufacture for delivering an antigen that induces a CTL response in an animal.Type: ApplicationFiled: May 3, 2006Publication date: February 5, 2009Inventors: Thomas M. Kundig, John J. L. Simard
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Patent number: 7364729Abstract: Disclosed herein are methods for inducing an immunological CTL response to an antigen by sustained, regular delivery of the antigen to a mammal so that the antigen reaches the lymphatic system. Antigen is delivered at a level sufficient to induce an immunologic CTL response in a mammal and the level of the antigen in the mammal's lymphatic system is maintained over time sufficient to maintain the immunologic CTL response. Also disclosed is an article of manufacture for delivering an antigen that induces a CTL response in an animal.Type: GrantFiled: December 19, 2005Date of Patent: April 29, 2008Assignee: Mannkind CorporationInventors: Thomas M. Kündig, John J. L. Simard
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Patent number: 7252824Abstract: Disclosed herein are immunogenic compositions, methods of designing immunogenic compositions, methods of treatment using immunogenic compositions, methods of evaluating cell-mediated immunity resulting from immunogenic compositions, research models, and methods of making research models, all of which relate to targeting tumor vasculature.Type: GrantFiled: March 7, 2002Date of Patent: August 7, 2007Assignee: Mannkind CorporationInventors: John J. L. Simard, David C. Diamond
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Patent number: 7232682Abstract: The invention disclosed herein is directed to methods of identifying a polypeptide suitable for epitope liberation including, for example, the steps of identifying an epitope of interest; providing a substrate polypeptide sequence including the epitope, wherein the substrate polypeptide permits processing by a proteasome; contacting the substrate polypeptide with a composition including the proteasome, under conditions that support processing of the substrate polypeptide by the proteasome; and assaying for liberation of the epitope. The invention further relates to vectors including a housekeeping epitope expression cassette and also vectors including epitope cluster regions. The housekeeping epitope(s) can be derived from a target-associated antigen. The housekeeping epitope can be liberatable, that is capable of liberation, from a translation product of the cassette by immunoproteasome processing.Type: GrantFiled: February 10, 2004Date of Patent: June 19, 2007Assignee: Mannkind CorporationInventors: John J. L. Simard, David C. Diamond, Zhiyong Qiu, Xiang-Dong Lei
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Patent number: 6977074Abstract: Disclosed herein are methods for inducing an immunological CTL response to an antigen by sustained, regular delivery of the antigen to a mammal so that the antigen reaches the lymphatic system. Antigen is delivered at a level sufficient to induce an immunologic CTL response in a mammal and the level of the antigen in the mammal's lymphatic system is maintained over time sufficient to maintain the immunologic CTL response. Also disclosed is an article of manufacture for delivering an antigen that induces a CTL response in an animal.Type: GrantFiled: February 2, 2001Date of Patent: December 20, 2005Assignee: Mannkind CorporationInventors: Thomas M. Kündig, John J. L. Simard
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Patent number: 6861234Abstract: A method of epitope discovery comprising the step of selecting an epitope from a population of peptide fragments of an antigen associated with a target cell, wherein the fragments have a known or predicted affinity for a major histocompatibility complex class I receptor peptide binding cleft, wherein the epitope selected corresponds to a proteasome cleavage product of the target cell.Type: GrantFiled: April 28, 2000Date of Patent: March 1, 2005Assignee: MannKind CorporationInventors: John J. L. Simard, David C. Diamond
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Publication number: 20040203051Abstract: The invention disclosed herein is directed to methods of identifying a polypeptide suitable for epitope liberation including, for example, the steps of identifying an epitope of interest; providing a substrate polypeptide sequence including the epitope, wherein the substrate polypeptide permits processing by a proteasome; contacting the substrate polypeptide with a composition including the proteasome, under conditions that support processing of the substrate polypeptide by the proteasome; and assaying for liberation of the epitope. The invention further relates to vectors including a housekeeping epitope expression cassette. The invention relates to epitope cluster regions and to vectors including epitope cluster regions. The invention also relates to a method of activating a T cell comprising contacting a substrate polypeptide with an APC and contacting the APC with a T cell.Type: ApplicationFiled: April 30, 2004Publication date: October 14, 2004Inventors: John J.L. Simard, David C. Diamond, Zhiyong Qiu, Xiang-Dong Lei
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Publication number: 20040180354Abstract: Disclosed herein are polypeptides, including epitopes, clusters, and antigens. Also disclosed are compositions that include said polypeptides and methods for their use.Type: ApplicationFiled: September 5, 2003Publication date: September 16, 2004Inventors: John J.L. Simard, David C. Diamond, Liping Liu, Zheng Liu
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Publication number: 20040132088Abstract: The invention disclosed herein is directed to methods of identifying a polypeptide suitable for epitope liberation including, for example, the steps of identifying an epitope of interest; providing a substrate polypeptide sequence including the epitope, wherein the substrate polypeptide permits processing by a proteasome; contacting the substrate polypeptide with a composition including the proteasome, under conditions that support processing of the substrate polypeptide by the proteasome; and assaying for liberation of the epitope. The invention further relates to vectors including a housekeeping epitope expression cassette and also vectors including epitope cluster regions. The housekeeping epitope(s) can be derived from a target-associated antigen. The housekeeping epitope can be liberatable, that is capable of liberation, from a translation product of the cassette by immunoproteasome processing.Type: ApplicationFiled: February 10, 2004Publication date: July 8, 2004Inventors: John J.L. Simard, David C. Diamond, Zhiyong Qiu, Xiang-Dong Lei
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Publication number: 20030228634Abstract: The invention disclosed herein is directed to methods of identifying a polypeptide suitable for epitope liberation including, for example, the steps of identifying an epitope of interest; providing a substrate polypeptide sequence including the epitope, wherein the substrate polypeptide permits processing by a proteasome; contacting the substrate polypeptide with a composition including the proteasome, under conditions that support processing of the substrate polypeptide by the proteasome; and assaying for liberation of the epitope. The invention further relates to vectors including a housekeeping epitope expression cassette. The housekeeping epitope(s) can be derived from a target-associated antigen, and the housekeeping epitope can be liberatable, that is capable of liberation, from a translation product of the cassette by immunoproteasome processing. The invention also relates to a method of activating a T cell comprising contacting a substrate polypeptide with an APC and contacting the APC with a T cell.Type: ApplicationFiled: November 7, 2002Publication date: December 11, 2003Inventors: John J.L. Simard, David C. Diamond, Zhiyong Qiu, Xiang-Dong Lei
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Publication number: 20030220239Abstract: Disclosed herein are polypeptides, including epitopes, clusters, and antigens. Also disclosed are compositions that include said polypeptides and methods for their use.Type: ApplicationFiled: April 4, 2002Publication date: November 27, 2003Inventors: John J. L. Simard, David C. Diamond, Liping Liu, Zhidong Xie