Patents by Inventor John J. Macklin

John J. Macklin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Coatings of semiconductor quantum dots for improved visibility of electrodes and pipettes
    Patent number: 9880149
    Abstract: A glass pipette such as an electrode for electrophysiological recording is coated with quantum dots. This greatly aids the ability to observe the glass pipette, particular in tissue as the quantum dots provide an excellent performance under two-photon illumination used to visualize objects at depths of hundreds of microns.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: January 30, 2018
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Igor L. Medintz, Bertalan K. Andrasfalvy, Kimihiro Susumu, James B. Delehanty, Alan L. Huston, John J. Macklin, Mladen Barbic
  • Coatings of Semiconductor Quantum Dots for Improved Visibility of Electrodes and Pipettes
    Publication number: 20150147803
    Abstract: A glass pipette such as an electrode for electrophysiological recording is coated with quantum dots. This greatly aids the ability to observe the glass pipette, particular in tissue as the quantum dots provide an excellent performance under two-photon illumination used to visualize objects at depths of hundreds of microns.
    Type: Application
    Filed: February 5, 2014
    Publication date: May 28, 2015
    Applicants: Institute of Experimental Medicine of the Hungarian Academy of Sciences, Howard Hughes Medical Institute, The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Igor L. Medintz, Bertalan K. Andrasfalvy, Kimihiro Susumu, James B. Delehanty, Alan L. Huston, John J. Macklin, Mladen Barbic
  • Method for sequencing and characterizing polymeric biomolecules using aptamers and a method for producing aptamers
    Publication number: 20030138831
    Abstract: The present invention relates to methods for sequencing a polymeric biomolecule and methods for structurally characterizing the same comprising using aptamers. In a preferred embodiment of this invention, these methods relate to using the single polymeric biomolecule. The invention also relates to a method for selecting aptamers useful for sequencing nucleic acids and aptamers generated by the method. The invention also provides aptamers that recognize and bind to AMP, dAMP, GMP, dGMP, CMP and dCMP.
    Type: Application
    Filed: December 3, 2002
    Publication date: July 24, 2003
    Applicant: Praelux Incorporated
    Inventors: Jae-Gyu Kwagh, John J. Macklin, Paul G. Mitsis, Kevin M. Ulmer
  • Method for sequencing and characterizing polymeric biomolecules using aptamers and a method for producing aptamers
    Patent number: 6515120
    Abstract: The present invention relates to methods for sequencing a polymeric biomolecule and methods for structurally characterizing the same comprising using aptamers. In a preferred embodiment of this invention, these methods relate to using the single polymeric biomolecule. The invention also relates to a method for selecting aptamers useful for sequencing nucleic acids and aptamers generated by the method. The invention also provides aptamers that recognize and bind to AMP, dAMP, GMP, dGMP, CMP and dCMP.
    Type: Grant
    Filed: May 25, 2000
    Date of Patent: February 4, 2003
    Assignee: Praelux Incorporated
    Inventors: Jae-Gyu Kwagh, John J. Macklin, Paul G. Mitsis, Kevin M. Ulmer
  • Traveling-wave laser-produced-plasma energy source for photoionization laser pumping and lasers incorporating said
    Patent number: 4870653
    Abstract: A traveling-wave, laser-produced-plasma, energy source used to obtain single-pass gain saturation of a photoionization pumped laser. A cylindrical lens is used to focus a pump laser beam to a long line on a target. Grooves are cut in the target to present a surface near normal to the incident beam and to reduce the area, and hence increase the intensity and efficiency, of plasma formation.
    Type: Grant
    Filed: April 22, 1988
    Date of Patent: September 26, 1989
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Mark H. Sher, John J. Macklin, Stephen E. Harris
  • Low voltage operation of arc discharge devices
    Patent number: 4504955
    Abstract: In an arc discharge device, a thin film bridges the gap(s) between adjacent electrodes, thereby enabling the arc discharge to be initiated and sustained by a low voltage D.C. supply. Application of the invention to both light source (e.g., laser) and material working (e.g., metal deposition) embodiments is described. One of the light source embodiments utilizes a cathode electrode which includes a pool of liquid Hg to generate a Hg ion plasma.
    Type: Grant
    Filed: August 13, 1982
    Date of Patent: March 12, 1985
    Assignee: AT&T Bell Laboratories
    Inventors: John J. Macklin, William T. Silfvast, Obert R. Wood, II
  • Continuous wave sper laser
    Patent number: 4498182
    Abstract: Continuous wave laser oscillation has been achieved in a segmented plasma excitation and recombination device in the presence of a low-pressure background gas which rapidly flows across the segmented electrodes. Laser action has been observed in Cd I at 1.40, 1.43, 1.44, and 1.64 .mu.m. Also disclosed are techniques for allowing the background gas to flow between the electrodes and for confining the expanding plasmas with shields in the vicinity of the gaps between electrodes.
    Type: Grant
    Filed: June 18, 1982
    Date of Patent: February 5, 1985
    Assignee: AT&T Bell Laboratories
    Inventors: John J. Macklin, William T. Silfvast, Obert R. Wood, II
  • Foil electrode SPER light source
    Patent number: 4441189
    Abstract: Numerous laser transitions in the visible and near-infrared in four metal vapors (Li, Al, Ca, and Cu) have been observed in the recombination phase of the expanding plasmas produced by a segmented plasma device employing foil electrodes. Also described is a segmented vapor plasma discharge in using Ni foil electrodes.
    Type: Grant
    Filed: April 9, 1982
    Date of Patent: April 3, 1984
    Assignee: Bell Telephone Laboratories, Incorporated
    Inventors: John J. Macklin, William T. Silfvast, Obert R. Wood, II
  • SPER Device for material working
    Patent number: 4411733
    Abstract: A segmented plasma excitation and recombination (SPER) device is employed in a deposition scheme in which the plasma generated in the gap between adjacent electrodes is formed into a beam of ions/atoms by flowing a background gas through the gap. The beam strikes a workpiece and deposits a layer of the vaporized electrode material thereon. Also described are techniques where the ions react with workpiece or the background gas to form a layer, as well as where the ions bombard the workpiece to etch away a layer.
    Type: Grant
    Filed: June 18, 1982
    Date of Patent: October 25, 1983
    Assignee: Bell Telephone Laboratories, Incorporated
    Inventors: John J. Macklin, William T. Silfvast, Obert R. Wood, II