Patents by Inventor John J. Talley

John J. Talley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2,5-DIALKYL-4-H/HALO/ETHER-PHENOL COMPOUNDS
    Publication number: 20150148430
    Abstract: The present disclosure provides phenolic compounds useful in the treatment of neurological conditions such as convulsions and tremors, having the structure of Formula (I): wherein R2, R4, & R5, are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating neurological conditions.
    Type: Application
    Filed: November 24, 2014
    Publication date: May 28, 2015
    Inventors: Max Baker, Rajesh Kumar Mishra, John J. Talley, Eduardo J. Martinez
  • No-releasing nonoate(nitrogen-bound)sulfonamide-linked-coxib anti-cancer agents
    Patent number: 8859781
    Abstract: The present invention provides NO-releasing NONOate(nitrogen bound)sulfonamide-linked-coxib anti-cancer agents, having the structure of Formula (I): wherein R1, X, L, R2, R3, R4, and Z are as defined in the detailed description; pharmaceutical compositions comprising at least one compound of Formula (I); and methods useful for healing wounds, preventing and treating cancer, or treating actinic keratosis, cystic fibrosis or acne, using a compound of Formula (I).
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: October 14, 2014
    Assignee: Euclises Pharmaceuticals, Inc.
    Inventors: Eduardo J. Martinez, John J. Talley, Kevin D. Jerome, Terri L. Boehm
  • NO-RELEASING NONOATE(NITROGEN-BOUND)SULFONAMIDE-LINKED-COXIB ANTI-CANCER AGENTS
    Publication number: 20140018544
    Abstract: The present invention provides NO-releasing NONOate(nitrogen bound)sulfonamide-linked-coxib anti-cancer agents, having the structure of Formula (I): wherein R1, X, L, R2, R3, R4, and Z are as defined in the detailed description; pharmaceutical compositions comprising at least one compound of Formula (I); and methods useful for healing wounds, preventing and treating cancer, or treating actinic keratosis, cystic fibrosis or acne, using a compound of Formula (I).
    Type: Application
    Filed: July 12, 2013
    Publication date: January 16, 2014
    Inventors: Eduardo J. Martinez, John J. Talley, Kevin D. Jerome, Terri L. Boehm
  • NO-RELEASING GUANIDINE-COXIB ANTI-CANCER AGENTS
    Publication number: 20140018403
    Abstract: The present disclosure provides NO-releasing guanidine-coxib anti-cancer agents, having the structure of Formula (I): wherein R1, R11, Z and L are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds of Formula (I); and methods useful for healing wounds, preventing and treating cancer, or treating actinic keratosis, cystic fibrosis, acne, or a disease mediated by arginine deficiency using a compound of Formula (I).
    Type: Application
    Filed: July 12, 2013
    Publication date: January 16, 2014
    Inventors: Eduardo J. Martinez, John J. Talley, Terri L. Boehm
  • Compounds and methods for the treatment of asthma
    Patent number: 8088935
    Abstract: Compounds and methods for the treatment of asthma are disclosed. The methods involve mast cell stabilization together with selective inhibition of iNOS. The compounds are combinations of a mast cell inhibiting moiety and an inhibitor of iNOS.
    Type: Grant
    Filed: December 23, 2004
    Date of Patent: January 3, 2012
    Assignee: Ironwood Pharmaceuticals, Inc.
    Inventors: James Pearson, John J. Talley, Mark G. Currie
  • ?- and ?-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Patent number: 7829564
    Abstract: ?-and ?-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Grant
    Filed: December 7, 2007
    Date of Patent: November 9, 2010
    Assignee: G.D. Searle LLC
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel P. Getman, Gary A. DeCrescenzo, John N. Freskos, Robert M. Heintz, Deborah E. Bertenshaw
  • ORGANOMETAL BENZENEPHOSPHONATE COUPLING AGENTS
    Publication number: 20090292135
    Abstract: The invention relates to chemical genera of organometal benzenephosphonates useful in cross-coupling organic synthesis, having general formula: where R is selected from boron, zinc, tin and silicon residues.
    Type: Application
    Filed: May 9, 2006
    Publication date: November 26, 2009
    Applicant: Ironwood Pharmaceuticals, Inc.
    Inventors: Timothy C. Barden, Peter Lee, Eduardo J. Martinez, Wayne C. Schairer, John J. Talley, JingJing Yang
  • BIPHENYLAZETIDINONE CHOLESTEROL ABSORPTION INHIBITORS
    Publication number: 20090131395
    Abstract: The invention relates to a chemical genus of 4-biphenyl-1-phenylazetidin-2-ones useful in the treatment of hypercholesterolemia and other disorders. The compounds have the general formula I: Pharmaceutical compositions and methods for treating cholesterol- and lipid-associated diseases are also disclosed.
    Type: Application
    Filed: May 5, 2006
    Publication date: May 21, 2009
    Applicant: MICROBIA, INC.
    Inventors: Stephen Antonelli, Regina Lundrigan, Eduardo J. Martinez, Wayne C. Schairer, John J. Talley, Timothy C. Barden, JingJing Yang, Daniel P. Zimmer
  • ?- and ?-Amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Patent number: 7531538
    Abstract: ?- and ?-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Grant
    Filed: May 15, 2006
    Date of Patent: May 12, 2009
    Assignee: G.D. Searle LLC
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel P. Getman, Gary A. DeCrescenzo, John N. Freskos, Deborah E. Bertenshaw, Robert M. Heintz
  • Processes for Production of 4-(Biphenylyl)Azetidin-2-One Phosphonic Acids
    Publication number: 20090099355
    Abstract: The present invention relates to processes for the production of 4-(biphenylyl)azetidin-2-one phosphonic acid derivatives of formula
    Type: Application
    Filed: May 25, 2006
    Publication date: April 16, 2009
    Applicant: MICROBIA, INC.
    Inventors: Stephen Antonelli, Timothy C. Barden, Peter Lee, Eduardo J. Martinez, Wayne C. Schairer, John J. Talley
  • ALPHA- AND BETA-AMINO ACID HYDROXYETHYLAMINO SULFONAMIDES USEFUL AS RETROVIRAL PROTEASE INHIBITORS
    Publication number: 20090023664
    Abstract: ?- and ?-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Application
    Filed: December 7, 2007
    Publication date: January 22, 2009
    Applicant: G.D. SEARLE LLC
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel P. Getman, Gary A. DeCrescenzo, John N. Freskos, Robert M. Heintz, Deborah E. Bertenshaw
  • Process For Production Of 4-Biphenylyazetidin-2-Ones
    Publication number: 20080287663
    Abstract: The present invention relates to processes for the production of 4-biphenylylazetidin-2-one derivatives of formula
    Type: Application
    Filed: May 8, 2006
    Publication date: November 20, 2008
    Applicant: MICROBIA, INC.
    Inventors: Peter Lee, Stephen Antonelli, Regina Lundrigan, Eduardo J. Martinez, Wayne C. Schairer, John J. Talley
  • Process for preparing prodrugs of benzenesulfonamide-containing COX-2 inhibitors
    Patent number: 7420061
    Abstract: Prodrugs of COX-2 inhibitors are described as being useful in treating inflammation and inflammation-related disorders.
    Type: Grant
    Filed: September 13, 2004
    Date of Patent: September 2, 2008
    Assignee: Pharmacia Corporation
    Inventors: John J. Talley, James W. Malecha, Stephen Bertenshaw, Matthew J. Graneto, Jeffery S. Carter, Jinglin Li, Srinivasan R. Nagarajan, David L. Brown, Donald J. Rogier, Jr., Thomas D. Penning, Ish K. Khanna, Xiangdong Xu, Richard M. Weier
  • Processes For Production of Phenolic 4-Biphenylylazetidin-2-Ones
    Publication number: 20080200669
    Abstract: The present invention relates to processes for the production of phenolic 4-biphenylylazetidin-2-one derivatives of formula
    Type: Application
    Filed: May 11, 2006
    Publication date: August 21, 2008
    Applicant: Microbia, Inc.
    Inventors: Timothy C. Barden, Peter Lee, Eduardo J. Martinez, Wayne C. Schairer, John J. Talley
  • BIS-SULFONAMIDE HYDROXYETHYLAMINO RETROVIRAL PROTEASE INHIBITORS
    Publication number: 20080176842
    Abstract: Bis-sulfonamido hydroxyethylamino compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to retroviral protease inhibiting compounds of the formula: or a pharmaceutically acceptable salt, prodrug or ester thereof, wherein the variables are as defined herein.
    Type: Application
    Filed: November 14, 2007
    Publication date: July 24, 2008
    Applicant: G.D. SEARLE LLC
    Inventors: John N. Freskos, Daniel P. Getman, John J. Talley, James A. Sikorski
  • 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES
    Publication number: 20080167255
    Abstract: 4-Biarylyl-1-phenylazetidin-2-ones useful for the treatment of hypercholesterolemia are disclosed. The compounds are of the general formula in which represents an aryl or heteroaryl residue; Ar represents an aryl residue; U is a two to six atom chain; and the R's represent substituents.
    Type: Application
    Filed: December 11, 2007
    Publication date: July 10, 2008
    Applicant: MICROBIA, INC.
    Inventors: Eduardo J. Martinez, John J. Talley, Stephen Antonelli, Timothy C. Barden, Regina Lundrigan-Soucy, Wayne C. Schairer, Jing-Jing Yang, Daniel P. Zimmer, Brian Cali, Mark G. Currie, Peter S. Yorgey
  • ?- and ?- amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Patent number: RE42889
    Abstract: ?- and ?-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Grant
    Filed: April 23, 2007
    Date of Patent: November 1, 2011
    Assignee: G.D. Searle LLC
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel P. Getman, Gary A. DeCrescenzo, John N. Freskos, Robert M. Heintz, Deborah E. Bertenshaw
  • ?- and ?-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Patent number: RE43596
    Abstract: ?- and ?-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Grant
    Filed: April 23, 2007
    Date of Patent: August 21, 2012
    Assignee: G.D. Searle LLC
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel P. Getman, Gary A. DeCrescenzo, John N. Freskos, Robert M. Heintz, Deborah E. Bertenshaw
  • ?- and ?-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
    Patent number: RE43802
    Abstract: ?- and ?-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Grant
    Filed: September 21, 2011
    Date of Patent: November 13, 2012
    Assignee: G.D. Searle LLC
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel P. Getman, Gary A. DeCrescenzo, John N. Freskos, Deborah E. Bertenshaw, Robert M. Heintz
  • 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-YL]benzenesulfonamide for the treatment of inflammation or an inflammation-associated disorder
    Patent number: RE44048
    Abstract: A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: or a pharmaceutically-acceptable salt thereof. A method of treating inflammation or an inflammation-associated disorder in a subject by administering a therapeutically-effective dose of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide, or a pharmaceutically-acceptable salt thereof, to the subject.
    Type: Grant
    Filed: November 14, 1994
    Date of Patent: March 5, 2013
    Assignee: G.D. Searle LLC
    Inventors: John J. Talley, Stephen R. Bertenshaw, Julie M. Miyashiro