Abstract: A block manifold for a fail safe actuator system allows the actuator operation with a hand pump if electrical power were not available. A method is available to isolate fail safe solenoid valves and an accumulator from a hand pump circuit to relieve the stored energy from the fail safe circuit. An additional set of pilot operated check valves were installed between the motor driven pump circuit and the hand pump circuit. These pilot operated check valves isolated the hand pump circuit from the fail safe dump solenoid and accumulator. These pilot actuated check valves also hold the actuator in the fail safe position as long as the hand pump system was not used. There is also a hydraulic bleed circuit to relieve the accumulator stored energy when the hand pump system was used.

Abstract: Compounds are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.

Abstract: Disclosed are topical compositions comprising at least one histone deacetylase (HDAC) inhibitor (HDI) and a carrier comprising petrolatum. Methods for using such compositions to treat or inhibit cancer and various skin diseases are also disclosed.

Abstract: A system for managing software builds is provided. The system comprises a code control system operable to maintain a code version and a information associated with the code version, a parser module in communication with the code control system, the parser module operable to parse the information associated with the code version and create a change report, and a compiler module in communication with the code control system and operable to compile the code version into an object version based on the change report. A method of managing software builds is also provided. A method for building a software version is also provided.

Abstract: Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor-mediated diseases, and as controls in assays for the identification of chemokine antagonists.

Abstract: Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally monocyclic and bicyclic compounds and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

Abstract: Substituted benzamide compounds are provided along with methods for the use of those compounds for treating cancer.

Abstract: Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

Abstract: Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

Abstract: Substituted benzamide compounds are provided along with methods for the use of those compounds for treating cancer.

Abstract: A diode laser-pumped magnetometer includes a diode laser that emits a polarized pumping laser beam with resonant optical radiation; and a K-cell through which a magnetic field is manifested from an independent source, the K-cell containing atoms with a dipole experiencing a torque due to the magnetic field. The atoms are excited by the resonant optical radiation of the pumping laser beam and periodically emitting a response radiation as they return to ground state such that the response radiation includes photons that indicate one unit of angular momentum indicative of the torque due to the magnetic field. Finally, a photodetector serves as a means for measuring the response radiation of the K-cell to indicate thereby a measure of the magnetic field in the K-cell from the independent magnetic source.

Abstract: The present invention concerns antitumor compounds. More particularly, the invention provides novel taxane derivatives, pharmaceutical compositions thereof, and their use as antitumor agents.

Abstract: The present invention concerns antitumor compounds. More particularly, the invention provides novel taxane derivatives, pharmaceutical compositions thereof, and their use as antitumor agents.

Abstract: An in-ground flower holder is provided with a body having a top opening defined by a planar or flanged area and a lower opening passage through which water may flow. An insert is located within the interior of the body, the insert having a gripping area which allows access to the insert by a user when the flower holder is embedded within the ground. A base of the insert is used to carry flowers placed within the body. A bottom surface of a base of the insert carries a plug member which is adapted to substantially a similar size as an opening formed as a funnel in the bottom of the body. When in one holding position, the plug and funnel form a watertight seal thereby holding any water within the interior. When the insert is moved to another position, the watertight seal is broken and a passage for water out of the interior is provided. A lock maintains the insert within the interior of the body. Additionally, the upper surface of the body or of the lock is configured such that indicia may be placed thereon.

Abstract: A design system for designing a tube for a gas turbine engine is described. The system including, in one embodiment, a computer workstation having a plurality of executable modules stored therein. The modules include a tube design module for routing a tube between tube fittings, a tube editing module for editing tube assembly geometry, and a tube detailing module for preparing detail drawings.

Abstract: A design system for designing brackets for gas turbine engines is described. The system may be implemented with a computer workstation and includes a part model library and a drawing note library. The computer workstation is configured to receive a bracket model in electronic form as input and has a number of executable modules stored therein. The system outputs a bracket master model and detail drawings. In one embodiment, the modules include a bracket intelligence builder module for generating intelligence data for the bracket model, a bracket unfolding module for unfolding a bracket model to a flat pattern, a bracket folding module to fold a bracket flat pattern, and a bracket minimum material check module to check for minimum distances between bracket pattern features. Other modules also are described and may form a elements of the system.

Abstract: There is provided a novel series of O-carboxymethylated .alpha.- and .beta.-glycolipid compounds of the formula ##STR1## wherein R is an acyl residue of a fatty acid;R.sup.1 is --(CH.dbd.CH).sub.m --(CH.sub.2).sub.n --CH.sub.3 ;R.sup.2, R.sup.3, R.sup.4 R.sup.5 and R.sup.6 each are independently hydrogen, unsubstituted or substituted alkanoyl, arylalkyl or arylcarbonyl wherein said substituent is selected from halogen, C.sub.1-4 alkyl, trifluoromethyl, hydroxy and C.sub.1-4 alkoxy;R.sup.3, R.sup.4 and R.sup.6 each are independently --CH.sub.2 COOR.sup.7, provided at least two of the R.sup.3, R.sup.4 and R.sup.6 substituents are --CH.sub.2 COOR.sub.7 ;m is an integer of 0 or 1;n is an integer of from 5 to 14, inclusive; andR.sup.

Abstract: The present invention concerns antitumor compounds. More particularly, the invention provides novel taxane derivatives, pharmaceutical compositions thereof, and their use as antitumor agents.

Abstract: The present invention relates to novel dihydroquinolines which are useful for cholesterol lowering and as antioxidant agents. Also provided is a process for preparing the dihydroquinolines of the present invention, pharmaceutical compositions, and a method of treating or inhibiting hypercholesterolemia, hyperlipidemia, atherosclerosis, and LDL oxidation which comprises administering to birds and mammals in need of such treatment an effective amount of a compound of the present invention.