Abstract: The present disclosure relates to certain (2S)—N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: An injection device for injecting medicament in a patient includes a syringe coupled to a housing and radially retained by a retaining rib. A needle guard is slideably coupled to the housing and spring biased in a distal direction by a return spring. A ram is slideably coupled to the housing and spring biased in the distal direction by a main spring. An initial position is defined by a retaining arm being disposed in the longitudinal path of the ram preventing firing. A released position is defined by the retaining arm being clear from the longitudinal path of the ram allowing the ram to extend distally. A locked position is defined by the retaining arm being disposed in the longitudinal path of the ram and a lock arm of the ram being disposed in the longitudinal path of the needle guard preventing the needle guard from being retracted.

Abstract: A mounting device may include a top plate including a cone-shaped center portion, a flange coupled to the cone-shaped center portion, a number of apertures defined in the flange, and a number of fasteners engaged with the apertures to couple the top plate to a surface of a structure. The flange seals a bottom side of the top plate to the surface of the structure. The flange includes a seal coupled to the bottom of the flange. The cone-shaped center portion has a convex paraboloid shape. The flange includes at least one surface that is parallel to a surface of the structure, and a transition between the cone-shaped center portion and the flange forms an angle. The top plate has a diameter sufficient to displace a load greater than 50 pounds over the surface of the structure.

Abstract: The booth has a base and a table is pivotably connected to the base. The table is movable from a stored positioned adjacent the base an in-use position where the table is positioned substantially perpendicular to the base. At least one bench is pivotably connected to the base. The at least one bench is movable from a stored position adjacent the base, an in-use position that is substantially perpendicular to the base. A support leg is pivotably connected to the table and to the at least one bench. The support leg is disposed to extend in a direction perpendicular to the table and the at least one bench when the table and at least one bench are in the in-use position.

Abstract: This invention relates to compounds of Formula (I): and enantiomers thereof, and to pharmaceutically acceptable salts of Formula (I) and said enantiomers, wherein L1, L2, R1, R2, R3 and n are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof.

Abstract: Authentication tokens, systems, and methods are described. An illustrative method is disclosed to include receiving an electronic file including a digital image, receiving biometric information that is associated with a person, modifying the electronic file with the biometric information such that one or more pixels in the digital image are replaced with the biometric information, and storing the modified electronic file as a digital authentication token to be used in connection with authorized publications of original digital work.

Abstract: A computer method for identifying product in a distributor's inventory system that fulfills a product request made via a natural language query. the natural language query is received as a product request including multiple words in sequential order. The words are vectorized into word-vectors that are concatenated and used to generate a query embedding. The query embedding is processed utilizing a trained product category classifier that predicts which product category the requested product belongs. Forward and backward sequence vectors are generated from the sequentially ordered words of the query that are concatenated and processed using a trained model specific to the predicted product category. The sequence vectors represent positional relationships between the words of the natural language query. Thereafter, the system identifies product attribute(s) embodied in the natural language query that each correspond to a predetermined key-characteristic of the category.

Abstract: A method of synchronising audio content arranged to be played by a second device with video content played by a first device, wherein the second device includes a camera, comprises: capturing at least a portion of the video content with the camera; performing image recognition on the captured video content to identify a set time point in the audio content; and commencing playing the audio content from a selected time point in the audio content corresponding to the set time point, such that the audio content is synchronous with the video content. A method of pre-preparing video content for use in such a synchronisation method is also described.

Abstract: Systems, methods, and computer program products are configured to apply k-anonymity to an answer to a query sent to a relational database. A query to the relational database is obtained, the relational database containing a plurality of records. A frequency of occurrence of the attributes in the relational database is determined, an anonymization rule set is created based on the frequency of occurrence of the attributes, the anonymization rule set defining which attributes are to be suppressed in the answer to the query, the anonymization rule set is used to generate the answer to the query, wherein the answer to the query has k-anonymity, and a display or other device is controlled based on the answer to the query.

Abstract: A device for treating a tissue opening includes a proximal portion including an elongated flexible member, a capsule releasably coupled to a distal end of the flexible member and including a lumen extending therethrough and a clip including a pair of arms movably housed within the capsule. A suture extending along a first one of the pair of arms and including a loop at a distal end thereof extending across an opening extending through the first one of the pair of arms. A suture grabbing element extending laterally from a second one of the pair of arms and including a hook so that, when the pair of arms are moved toward a closed configuration, the hook extends through the opening to grab the loop and draw the distal end of the suture from the first one of the pair of arms toward the second one of the pair of arms.

Abstract: Systems, methods, devices, computer readable media, and other various embodiments are described for location management processes in wearable electronic devices. Performance of such devices is improved with reduced time to first fix of location operations in conjunction with low-power operations. In one embodiment, low-power circuitry manages high-speed circuitry and location circuitry to provide location assistance data from the high-speed circuitry to the low-power circuitry automatically on initiation of location fix operations as the high-speed circuitry and location circuitry are booted from low-power states. In some embodiments, the high-speed circuitry is returned to a low-power state prior to completion of a location fix and after capture of content associated with initiation of the location fix. In some embodiments, high-speed circuitry is booted after completion of a location fix to update location data associated with content.

Abstract: A dock for a surgical equipment holder is disclosed. The dock for a surgical equipment holder includes a base having a central arm mount and a lower clamping jaw. The dock for a surgical equipment holder also includes an upper clamp jaw movably coupled to the base. The dock for a surgical equipment holder also includes a central docking arm coupled to the central arm mount and a central ball cup coupled to the to the central docking arm. The dock for a surgical equipment holder also includes a central attachment nut coupled to the central ball cup. The central attachment nut may include an extendable moment arm, and the dock may also include a ball coupled between the central ball cup and the central attachment nut and a surgical equipment holder attached to the ball.

Abstract: A pet toy includes a ring shaped peripheral body and an interior dispenser. An interior curved engaging surface of the peripheral body engages an exterior spherical surface of the dispenser. A curvature of the interior engaging surface allows the dispenser to continuously roll or rotate, yet maintain engagement with the peripheral body when the peripheral body is displaced by contact. The dispenser is hollow thereby defining a chamber to receive treats. One or more dispensing openings are provided on the dispenser to selectively dispense treats. The openings can be sized to selectively dispense treats of various sizes and shapes. The invention further includes a method of dispensing treats from a pet toy and a combination comprising the pet toy and selected treats loaded within the chamber.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for performing protein design. In one aspect, a method comprises: processing an input characterizing a target protein structure of a target protein using an embedding neural network having a plurality of embedding neural network parameters to generate an embedding of the target protein structure of the target protein; determining a predicted amino acid sequence of the target protein based on the embedding of the target protein structure, comprising: conditioning a generative neural network having a plurality of generative neural network parameters on the embedding of the target protein structure; and generating, by the generative neural network conditioned on the embedding of the target protein structure, a representation of the predicted amino acid sequence of the target protein.

Abstract: A removable hot box is disclosed that includes a lower hot box portion, comprising: a lower housing comprising a plurality of lower clamping structures to clamp the lower housing to a press and locating structures to provide repeatable placing in the press; and a lower heating platen, received within the lower housing, wherein the lower housing or the lower heating platen comprises lower electrical connectors to provide a lower electrical connection to a heating system and lower cooling connectors to provide a lower cooling connection to a cooling system; and an upper hot box portion, positionable above the lower hot box portion and comprising: an upper housing comprising a plurality of upper clamping structures to clamp the upper housing to the press; an upper heating platen, received within the upper housing.

Abstract: A method for a first UE to perform sidelink communication with a second UE is provided. The method initiates a sidelink channel with the second UE based on a first resource set in a plurality of resource sets stored in the first UE. The method then performs a ranging process to identify at least a first distance between the first UE and the second UE when the sidelink channel between the first and second UEs is established. The method further sets a timer based on at least the identified first distance, the timer for determining when to initiate a subsequent sidelink channel with the second UE. when the timer is expired, the method initiates the subsequent sidelink channel with the second UE and performs a subsequent ranging process to identify at least a second distance between the first UE and the second UE.

Abstract: A workspace includes a power input receptacle configured to receive an input power at a first voltage level, wherein the first voltage level is an extra-low voltage. The workspace further includes a voltage regulator configured to regulate the input power and output a regulated power at a second voltage level and a power distribution bus. The power distribution bus is configured to receive the input power from the power input receptacle. The workspace further includes a safety disconnect configured to disconnect the input power from the power distribution bus in response to detecting an adverse condition.

Abstract: Provided herein are, among other things, methods for treating a patient suffering from a CD38+ cancer.

Abstract: An enteral feeding tubing connector comprises a body, a bore extending through the body, and a collet slidably disposed in the bore at a first end of the body. The collet is dimensioned to receive and engage a portion of tubing inserted into the collet, and is configured to resist withdrawal of the tubing from the bore and body upon application of force to the tubing that moves the collet out of the bore. A lock is provided on the first end of the body, and is configured to selectively engage the collet and prevent movement of the collet outward relative to the body. A tubing connection is provided at a second, opposite end of the body, the tubing connection providing fluid communication between another portion of tubing, the bore extending through the body, and the portion of tubing inserted into the collet.