Patents by Inventor John K. Simons
John K. Simons has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11497712Abstract: The present disclosure provides a method of preparing a pharmaceutical composition. The method includes transferring a predetermined quantity of an excipient mixture from a second vessel to a first vessel. The excipient mixture transferred from the second vessel includes a liquid-state second quantity of a hydrofluoroalkane propellant and a first solubilized excipient comprising a low-molecular weight poly(ethylene oxide) polymer. The method further includes contacting at least one pharmaceutically-active compound with the excipient mixture under conditions that facilitate forming an intermixture comprising the propellant, the polymer, and the compound. Before transferring the excipient mixture, the first vessel contains a vapor-phase first quantity of the hydrofluoroalkane propellant and an effective amount of the at least one pharmaceutically-active compound.Type: GrantFiled: February 22, 2019Date of Patent: November 15, 2022Assignee: Kindeva Drug Delivery L.P.Inventors: Stephen W. Stein, David W. Schultz, John K. Simons, William F. Hansen
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Patent number: 10370183Abstract: Powder feeding apparatuses (100; 200) and methods. The powder feeding apparatus (100; 200) can include first and second cylindrical rollers (106, 107; 206, 207) adjacent to each other and spaced apart by a gap (108; 208). The first roller (106; 206) can rotate intermittently and independently of the second roller (107; 207). The second roller can rotate intermittently and independently of the first roller. Powder from a hopper (102; 202) is fed through the gap as one or both rollers rotate. The powder feeding method may include a method of feeding powder by intermittently and alternately advancing a first and second roller to dispense powder from the hopper.Type: GrantFiled: July 2, 2013Date of Patent: August 6, 2019Assignee: ADAMIS PHARMACEUTICALS CORPORATIONInventors: John K. Simons, Zhaolin Wang
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Publication number: 20190183784Abstract: The present disclosure provides a method of preparing a pharmaceutical composition. The method includes transferring a predetermined quantity of an excipient mixture from a second vessel to a first vessel. The excipient mixture transferred from the second vessel includes a liquid-state second quantity of a hydrofluoroalkane propellant and a first solubilized excipient comprising a low-molecular weight poly(ethylene oxide) polymer. The method further includes contacting at least one pharmaceutically-active compound with the excipient mixture under conditions that facilitate forming an intermixture comprising the propellant, the polymer, and the compound. Before transferring the excipient mixture, the first vessel contains a vapor-phase first quantity of the hydrofluoroalkane propellant and an effective amount of the at least one pharmaceutically-active compound.Type: ApplicationFiled: February 22, 2019Publication date: June 20, 2019Applicant: 3M INNOVATIVE PROPERTIES COMPANYInventors: STEPHEN W. STEIN, DAVID W. SCHULTZ, JOHN K. SIMONS, WILLIAM F. HANSEN
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Publication number: 20170189329Abstract: The present disclosure provides a method of preparing a pharmaceutical composition. The method includes transferring a predetermined quantity of an excipient mixture from a second vessel to a first vessel. The excipient mixture transferred from the second vessel includes a liquid-state second quantity of a hydrofluoroalkane propellant and a first solubilized excipient comprising a low-molecular weight poly(ethylene oxide) polymer. The method further includes contacting at least one pharmaceutically-active compound with the excipient mixture under conditions that facilitate forming an intermixture comprising the propellant, the polymer, and the compound. Before transferring the excipient mixture, the first vessel contains a vapor-phase first quantity of the hydrofluoroalkane propellant and an effective amount of the at least one pharmaceutically-active compound.Type: ApplicationFiled: July 28, 2015Publication date: July 6, 2017Applicant: 3M INNOVATIVE PROPERTIES COMPANYInventors: STEPHEN W. STEIN, DAVID W. SCHULTZ, JOHN K. SIMONS, WILLIAM F. HANSEN
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Patent number: 9119945Abstract: A device (100) for applying a microneedle array to a skin surface. The device comprises a base (120) defining a skin contacting plane, an array component having a skin facing side comprising a microneedle array, and at least one connecting member (140) having a first portion affixed through a first hinge (142) to the base and a second portion affixed to the array component. The connecting member has a first equilibrium position with the microneedle array in a recessed position within the device and a second equilibrium position with the microneedle array positioned so as to be able to contact a skin surface.Type: GrantFiled: April 20, 2007Date of Patent: September 1, 2015Assignee: 3M Innovative Properties CompanyInventors: John K. Simons, Franklyn L. Frederickson
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Publication number: 20150197396Abstract: Powder feeding apparatuses (100; 200) and methods. The powder feeding apparatus (100; 200) can include first and second cylindrical rollers (106, 107; 206, 207) adjacent to each other and spaced apart by a gap (108; 208). The first roller (106; 206) can rotate intermittently and independently of the second roller (107; 207). The second roller can rotate intermittently and independently of the first roller. Powder from a hopper (102; 202) is fed through the gap as one or both rollers rotate. The powder feeding method may include a method of feeding powder by intermittently and alternately advancing a first and second roller to dispense powder from the hopper.Type: ApplicationFiled: July 2, 2013Publication date: July 16, 2015Inventors: John K. Simons, Zhaolin Wang
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Patent number: 8900180Abstract: Coatable compositions and coatings derived from the coatable compositions, and microarrays comprising such coatings are described. In one aspect, the invention provides a microarray comprising: a plurality of microneedles extending from a support substrate; a coating deposited on at least one of the plurality of microneedles, the coating comprising an active agent and a biological salt. In another aspect, the invention provides a coatable composition, comprising: active agent; a biological salt; and solvent. In still another aspect, the invention provides a dried coating coated on a microneedle, the coating comprising: an active agent; and a biological salt.Type: GrantFiled: November 17, 2006Date of Patent: December 2, 2014Assignee: 3M Innovative Properties CompanyInventors: James T. Wolter, John K. Simons, Peter R. Johnson
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Publication number: 20090198189Abstract: A device (100) for applying a microneedle array to a skin surface. The device comprises a base (120) defining a skin contacting plane, an array component having a skin facing side comprising a microneedle array, and at least one connecting member (140) having a first portion affixed through a first hinge (142) to the base and a second portion affixed to the array component. The connecting member has a first equilibrium position with the microneedle array in a recessed position within the device and a second equilibrium position with the microneedle array positioned so as to be able to contact a skin surface.Type: ApplicationFiled: April 20, 2007Publication date: August 6, 2009Applicant: 3M Innovative Properties CompanyInventors: John K. Simons, Franklyn L. Frederickson
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Publication number: 20080294116Abstract: Coatable compositions and coatings derived from the coatable compositions, and microarrays comprising such coatings are described. In one aspect, the invention provides a microarray comprising: a plurality of microneedles extending from a support substrate; a coating deposited on at least one of the plurality of microneedles, the coating comprising an active agent and a biological salt. In another aspect, the invention provides a coatable composition, comprising: active agent; a biological salt; and solvent. In still another aspect, the invention provides a dried coating coated on a microneedle, the coating comprising: an active agent; and a biological salt.Type: ApplicationFiled: November 17, 2006Publication date: November 27, 2008Inventors: James T. Wolter, John K. Simons, Peter R. Johnson