Abstract: Braces for loading and/or unloading knees, elbows and other joints. Such braces feature a stiffener which may be substantially permanently configured in shape to cooperate with the brace in applying tension to locations on the limb proximal and distal to the joint being loaded and/or unloaded, which counteract forces applied by the stiffener to the joint. A bending tool which may be accompanied by use of a goniometer may be employed for proper configuration of the stiffener using the wearer's limb geometry as a reference. Such braces are particularly effective for treating conditions such as compartmental osteoarthritis.

Abstract: Braces for loading and/or unloading knees, elbows and other joints. Such braces feature a stiffener which may be substantially permanently configured in shape to cooperate with the brace in applying tension to locations on the limb proximal and distal to the joint being loaded and/or unloaded, which counteract forces applied by the stiffener to the joint. A bending tool which may be accompanied by use of a goniometer may be employed for proper configuration of the stiffener using the wearer's limb geometry as a reference. Such braces are particularly effective for treating conditions such as compartmental osteoarthritis.

Abstract: Braces for loading and/or unloading knees, elbows and other joints. Such braces feature a stiffener which may be substantially permanently configured in shape to cooperate with the brace in applying tension to locations on the limb proximal and distal to the joint being loaded and/or unloaded, which counteract forces applied by the stiffener to the joint. A bending tool which may be accompanied by use of a goniometer may be employed for proper configuration of the stiffener using the wearer's limb geometry as a reference. Such braces are particularly effective for treating conditions such as compartmental osteoarthritis.

Abstract: Braces for loading and/or unloading knees, elbows and other joints. Such braces feature a stiffener which may be substantially permanently configured in shape to cooperate with the brace in applying tension to locations on the limb proximal and distal to the joint being loaded and/or unloaded, which counteract forces applied by the stiffener to the joint. A bending tool which may be accompanied by use of a goniometer may be employed for proper configuration of the stiffener using the wearer's limb geometry as a reference. Such braces are particularly effective for treating conditions such as compartmental osteoarthritis.

Abstract: A method in which a temperature gradient is generated across a "gradient" block, and an apparatus comprising a block across which a temperature gradient can be generated. By setting up such a gradient, multiple reaction mixtures held in wells on the gradient block can be simultaneously run at temperatures which differ only slightly, thereby permitting an optimum temperature for the reaction to be quickly identified. In a preferred embodiment the gradient block is integrated into a thermal cycler used for nucleic acid amplification reactions.