Patents by Inventor John L. Wallace
John L. Wallace has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240082200Abstract: The present application relates to methods of treating urologic chronic pelvic pain syndrome (UCPPS) or pain associated with UCPPS using a compound of Formula I, or a pharmaceutically acceptable salt, prodrug and/or solvate thereof. UCPPS encompasses interstitial cystitis/bladder pain syndrome (IC/BPS) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).Type: ApplicationFiled: August 24, 2023Publication date: March 14, 2024Inventors: John L. Wallace, Marcelo N. Muscará, Soraia Kátia Pereira Costa, David Vaughan
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Patent number: 8696365Abstract: Student growth can be defined, tracked, and analyzed using a method that comprises PLAN, ASSESS and REFLECT steps, potentially in conjunction with related sub-steps. This type of method can be facilitated using computer software that can be deployed over a remote network, and that can present a number of screens relevant to defining, tracking and analyzing student growth to a user.Type: GrantFiled: May 17, 2013Date of Patent: April 15, 2014Assignee: Align, Assess, Achieve, LLCInventors: Kathleen M. Bainbridge, Sheila M. Wallace, John L. Wallace, Maurice R. Holman
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Patent number: 8541398Abstract: The present invention relates to derivatives of non-steroidal anti-inflammatory drugs (NSAIDs) having improved anti-inflammatory properties useful in the treatment of inflammation, pain and fever. More particularly, NSAIDs are derivatized with a hydrogen sulfide (H2S) releasing moiety to produce novel anti-inflammatory compounds having reduced side effects.Type: GrantFiled: February 11, 2010Date of Patent: September 24, 2013Assignee: Antibe Therapeutics Inc.Inventors: John L. Wallace, Giuseppe Cirino, Vincenzo Santagada, Giuseppe Caliendo
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Patent number: 8114858Abstract: The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.Type: GrantFiled: December 29, 2010Date of Patent: February 14, 2012Assignee: Antibe Therapeutics Inc.Inventors: John L. Wallace, Giuseppe Cirino, Giuseppe Caliendo, Anna Sparatore, Vincenzo Santagada, Stefano Fiorucci
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Patent number: 8114857Abstract: The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.Type: GrantFiled: December 29, 2010Date of Patent: February 14, 2012Assignee: Antibe Therapeutics Inc.Inventors: John L. Wallace, Giuseppe Cirino, Giuseppe Caliendo, Anna Sparatore, Vicenzo Santagada, Stefano Fiorucci
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Publication number: 20110144188Abstract: Unique salts of trimebutine and N-monodesmethyl trimebutine, and their corresponding stereoisomers, having improved analgesic properties useful in the treatment of visceral pain are provided. The salts of the present invention are particularly useful in the treatment of conditions characterized by abdominal pain, such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), diabetic gastroparesis, and dyspepsia.Type: ApplicationFiled: June 6, 2007Publication date: June 16, 2011Applicant: Antibe Therapeutics Inc.Inventors: John L. Wallace, Giuseppe Cirino, Vincenzo Santagada, Giuseppe Caliendo
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Publication number: 20110130368Abstract: The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.Type: ApplicationFiled: December 29, 2010Publication date: June 2, 2011Applicant: ANTIBE THERAPEUTICS INC.Inventors: JOHN L. WALLACE, VINCENZO SANTAGADA, STEFANO FIORUCCI, GIUSEPPE CIRINO, GIUSEPPE CALIENDO, ANNA SPARATORE
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Publication number: 20110098257Abstract: The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.Type: ApplicationFiled: December 29, 2010Publication date: April 28, 2011Applicant: ANTIBE THERAPEUTICS INC.Inventors: JOHN L. WALLACE, GIUSEPPE CIRINO, GIUSEPPE CALIENDO, ANNA SPARATORE, VINCENZO SANTAGADA, STEFANO FIORUCCI
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Patent number: 7910568Abstract: The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.Type: GrantFiled: March 31, 2006Date of Patent: March 22, 2011Assignee: Antibe Therapeutics Inc.Inventors: John L. Wallace, Giuseppe Cirino, Giuseppe Caliendo, Anna Sparatore, Vincenzo Santagada, Stefano Fiorucci
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Patent number: 7879827Abstract: The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.Type: GrantFiled: February 10, 2009Date of Patent: February 1, 2011Assignee: Antibe Therapeutics Inc.Inventors: John L. Wallace, Giuseppe Cirino, Giuseppe Caliendo, Anna Sparatore, Vincenzo Santagada, Stefano Fiorucci
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Publication number: 20090306412Abstract: Derivatives of drugs are provided, said derivatives comprising the H2S-releasing moiety 4-hydroxythiobenzamide that is either covalently linked to the drug or forms a salt with the drug. The compounds of the present invention exhibit enhanced activity or reduced side effects or both.Type: ApplicationFiled: July 18, 2007Publication date: December 10, 2009Applicant: ANTIBE THERAPEUTICS INC.Inventors: John L. Wallace, Giuseppe Cirino, Vincenzo Santagada, Giuseppe Caliendo
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Publication number: 20090233886Abstract: The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.Type: ApplicationFiled: February 10, 2009Publication date: September 17, 2009Applicant: ANTIBE THERAPEUTICS INC.Inventors: John L. Wallace, Giuseppe Cirino, Giuseppe Caliendo, Anna Sparatore, Vincenzo Santagada, Stefano Fiorucci
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Publication number: 20090227597Abstract: Compounds of formula (I) wherein R1 is H, C1-C3-alkyl, C3-C5-cycloalkyl or C1-C3-perfluoroalkyl, R2 is H, C1-C6-alkyl optionally substituted by OH, C1-C3-alkoxy or C1-C3-perfluoroalkyl, R3 is C1-C6-alkyl, C3-C6-alkenyl, C3-C6-alkinyl, C3-C7-cycloalkyl, C1-C6-perfluoroalkyl or C3-C6-cycloalkyl-C1-C6-alkyl, R4=H, ADT-OH, cysteine, agmatine, arginine, aminoguanidine or agents releasing or stimulating the release of hydrogen sulfide, and salts thereof. The compounds are suitable for treating impotence, cardiovascular disorders, diseases characterized by disorders of gut motility, gastropathy of diabetic and nondiabetic origin, in general diseases where cytoprotection is important.Type: ApplicationFiled: August 25, 2005Publication date: September 10, 2009Applicant: CTG PHARMA S.R.L.Inventors: John L. Wallace, Anna Sparatore
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Patent number: 7498355Abstract: The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.Type: GrantFiled: March 31, 2006Date of Patent: March 3, 2009Assignee: Antibe Therapeutics Inc.Inventors: John L. Wallace, Giuseppe Cirino, Giuseppe Caliendo, Anna Sparatore, Vincenzo Santagada, Stefano Fiorucci
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Publication number: 20080207564Abstract: The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.Type: ApplicationFiled: March 31, 2006Publication date: August 28, 2008Applicant: ANTIBE THERAPEUTICS INC.Inventors: John L. Wallace, Giuseppe Cirino, Giuseppe Caliendo, Anna Sparatore, Vicenzo Santagada, Stefano Fiorucci
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Patent number: 7326809Abstract: The present invention provides L-arginine salts of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these L-arginine salts of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of an inflammatory condition of the GI tract such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS).Type: GrantFiled: May 27, 2005Date of Patent: February 5, 2008Assignee: Antibe Therapeutics Inc.Inventors: John L. Wallace, Giuseppe Cirino, Anna Sparatore
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Patent number: 5620899Abstract: Disclosed is a method for the detection of gastric epithelial damage and a method which is performed by administering a disaccharide to a patient, assaying the patient's blood or urine for the presence of the disaccharide and correlating the determined disaccharide assay value to gastric epithelial damage.Type: GrantFiled: February 3, 1994Date of Patent: April 15, 1997Inventors: Jonathan B. Meddings, Lloyd Sutherland, John L. Wallace
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Patent number: 5605840Abstract: Disclosed is a method for the detection of gastric epithelial damage and a method which is performed by administering a disaccharide to a patient, assaying the patient's blood or urine for the presence of the disaccharide and correlating the determined disaccharide assay value to gastric epithelial damage.Type: GrantFiled: May 31, 1995Date of Patent: February 25, 1997Inventors: Jonathan B. Meddings, Lloyd Sutherland, John L. Wallace
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Patent number: 4889765Abstract: Disclosed are coating compositions, coated articles made using said coating compositions and processes for preparing the same. More particularly disclosed are aqueous ink-receptive, water-based coatings which are smudgeproof and which will not wash off with water.Type: GrantFiled: December 22, 1987Date of Patent: December 26, 1989Assignee: W. R. Grace & Co.Inventor: John L. Wallace
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Patent number: 4514012Abstract: An excavatory machine for use in coal and other mining, has a pair of rotary cutters for simultaneous presentation to the work. The cutters are mounted on the ends of a medially fulcrumed lever which can be swung about its fulcrum so to increase the work ambit of the combined cutters. The fulcrum has means for raising and lowering it and holding it at selected elevation so to suit the height of the seam being worked. The cutter assembly is mounted on a saddle which is laterally slidable and drivable from side-to-side of a base slidable along the excavation floor in the direction the work is required to follow. This base is furnished with means enabling it to be nudged along in the said direction so to force the cutters into the work.The base is provided with conveyor means to take away excavated matter and also with mechanism by which the path followed by the base may be up-or down-trended.Type: GrantFiled: July 25, 1983Date of Patent: April 30, 1985Assignee: Maintel Pty. LimitedInventor: John L. Wallace