Patents by Inventor John Lamoureux
John Lamoureux has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11185794Abstract: Described are a fraction collector and a method of fraction collection for a liquid chromatography system. The method includes diverting a liquid chromatography system flow from a waste channel to a collection tube at a start of a fraction collection window and collecting the system flow dispensed from the collection tube during the fraction collection window. At the end of the window, the system flow is diverted to the waste channel and a flow of a wash solvent is provided to the collection tube to dispense liquid remaining in the collection tube at the end of the window from the collection tube. The method can increase the amount of the collected fraction and can reduce or eliminate cross-contamination of a subsequently collected fraction. The method is useful for analytical scale applications where the collected fractions may have volumes defined by a limited number of drops dispensed from the collection tube.Type: GrantFiled: February 26, 2015Date of Patent: November 30, 2021Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: Joshua A. Burnett, James Usowicz, Marc Lemelin, Lucas O. Tiziani, John Lamoureux, Aaron Lebeau
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Patent number: 9643103Abstract: A method of preparing a liquid mixture for use in a liquid chromatography system is provided. The mixture comprises one or more acids, one or more bases, one or more salts, and one or more solvents, and the method comprises the steps of: i) calculating pH and/or salt concentration at a particular time t from a user-determined gradient function; and ii) based on the values obtained in step (i), calculating percent acid, percent base, percent salt and percent solvent in the liquid mixture at time t. A liquid chromatography system incorporating such method is also provided.Type: GrantFiled: May 24, 2011Date of Patent: May 9, 2017Assignee: Waters Technologies CorporationInventors: Richard W. Andrews, John Heden, Michael Jackson, John Lamoureux, Guo-Zhong Li, Barry Sunray, Thomas E. Wheat
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Coordinating injector-valve switching with pump-stroke timing to mitigate effects of pressure pulses
Patent number: 9523662Abstract: A liquid chromatography system includes an autosampler with an injector valve by which a sample at low pressure within a sample loop is introduced into a high-pressure solvent mixture stream. A solvent delivery system includes a pump in fluidic communication with the injector valve of the autosampler to deliver the solvent mixture stream thereto. The solvent delivery system further comprises a processor that calculates a number of strokes of the pump needed to deliver the solvent mixture stream to the injector valve of the autosampler. The processor counts strokes of the pump during delivery of the solvent mixture stream. In response to a stroke count equaling the calculated number of strokes, the processor signals the autosampler to switch the injector valve to introduce the sample to the solvent mixture stream during a pump transfer period within which the pump performs pressure control to compensate for a drop in pressure.Type: GrantFiled: November 11, 2010Date of Patent: December 20, 2016Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: John Heden, John Lamoureux, Miguel Soares, Guo-Zhong Li -
Patent number: 9519291Abstract: A liquid chromatography system includes an autosampler that prepares a sample for introduction to a solvent stream and a solvent delivery system that delivers a solvent stream to the autosampler. Delivery of the solvent stream occurs in parallel with the autosampler's pre-injection operations. The autosampler starts pre-injection operations to make the sample ready for injection into the mixture stream, and the solvent delivery system starts delivery of a solvent stream to the autosampler. The start of the solvent stream delivery is coordinated with the start of the pre-injection operations such that the solvent stream arrives at the autosampler approximately coincident with when the autosampler completes the pre-injection operations, making the sample ready for injection.Type: GrantFiled: November 11, 2010Date of Patent: December 13, 2016Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: John Heden, John Lamoureux, Miguel Soares, Guo-Zhong Li
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Publication number: 20150246296Abstract: Described are a fraction collector and a method of fraction collection for a liquid chromatography system. The method includes diverting a liquid chromatography system flow from a waste channel to a collection tube at a start of a fraction collection window and collecting the system flow dispensed from the collection tube during the fraction collection window. At the end of the window, the system flow is diverted to the waste channel and a flow of a wash solvent is provided to the collection tube to dispense liquid remaining in the collection tube at the end of the window from the collection tube. The method can increase the amount of the collected fraction and can reduce or eliminate cross-contamination of a subsequently collected fraction. The method is useful for analytical scale applications where the collected fractions may have volumes defined by a limited number of drops dispensed from the collection tube.Type: ApplicationFiled: February 26, 2015Publication date: September 3, 2015Inventors: Joshua A. Burnett, James Usowicz, Marc Lemelin, Lucas O. Tiziani, John Lamoureux, Aaron Lebeau
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Publication number: 20130206666Abstract: A method of preparing a liquid mixture for use in a liquid chromatography system is provided. The mixture comprises one or more acids, one or more bases, one or more salts, and one or more solvents, and the method comprises the steps of: i) calculating pH and/or salt concentration at a particular time t from a user-determined gradient function; and ii) based on the values obtained in step (i), calculating percent acid, percent base, percent salt and percent solvent in the liquid mixture at time t. A liquid chromatography system incorporating such method is also provided.Type: ApplicationFiled: May 24, 2011Publication date: August 15, 2013Applicant: WATERS TECHNOLOGIES CORPORATIONInventors: Richard W. Andrews, John Heden, Michael Jackson, John Lamoureux, Guo-Zhong Li, Barry Sunray, Thomas E. Wheat
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Publication number: 20120304745Abstract: A liquid chromatography system includes an autosampler that prepares a sample for introduction to a solvent stream and a solvent delivery system that delivers a solvent stream to the autosampler. Delivery of the solvent stream occurs in parallel with the autosampler's pre-injection operations. The autosampler starts pre-injection operations to make the sample ready for injection into the mixture stream, and the solvent delivery system starts delivery of a solvent stream to the autosampler. The start of the solvent stream delivery is coordinated with the start of the pre-injection operations such that the solvent stream arrives at the autosampler approximately coincident with when the autosampler completes the pre-injection operations, making the sample ready for injection.Type: ApplicationFiled: November 11, 2010Publication date: December 6, 2012Applicant: WATERS TECHNOLOGIES CORPORATIONInventors: John Heden, John Lamoureux, Miguel Soares, Guo-Zhong Li
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COORDINATING INJECTOR-VALVE SWITCHING WITH PUMP-STROKE TIMING TO MITIGATE EFFECTS OF PRESSURE PULSES
Publication number: 20120303167Abstract: A liquid chromatography system includes an autosampler with an injector valve by which a sample at low pressure within a sample loop is introduced into a high-pressure solvent mixture stream. A solvent delivery system includes a pump in fluidic communication with the injector valve of the autosampler to deliver the solvent mixture stream thereto. The solvent delivery system further comprises a processor that calculates a number of strokes of the pump needed to deliver the solvent mixture stream to the injector valve of the autosampler. The processor counts strokes of the pump during delivery of the solvent mixture stream. In response to a stroke count equaling the calculated number of strokes, the processor signals the autosampler to switch the injector valve to introduce the sample to the solvent mixture stream during a pump transfer period within which the pump performs pressure control to compensate for a drop in pressure.Type: ApplicationFiled: November 11, 2010Publication date: November 29, 2012Applicant: WATERS TECHNOLOGIES CORPORATIONInventors: John Heden, John Lamoureux, Miguel Soares, Guo-Zhong Li -
Patent number: 8160751Abstract: Systems, devices, and methods to mitigate the pressure disturbance associated with the injection of low-pressure analyte samples into a high-pressure HPLC fluid stream, to enhance chromatographic performance related to retention time and reproducibility. The preferred embodiment coordinates the injection run with active pressure control of a binary solvent delivery system to virtually eliminate the customary pressure drop when the low-pressure loop is brought on line. An additional benefit that enhances reproducibility is accomplished by forcing a consistent timing relationship between the injection run, the mechanical position of the delivery pump pistons, and the start and subsequent gradient delivery.Type: GrantFiled: February 25, 2011Date of Patent: April 17, 2012Assignee: Waters Technologies CorporationInventors: Stanley P. Pensak, Jr., John Heden, Steven J. Ciavarini, John Lamoureux, Miguel Soares
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Publication number: 20110202188Abstract: Systems, devices, and methods to mitigate the pressure disturbance associated with the injection of low-pressure analyte samples into a high-pressure HPLC fluid stream, to enhance chromatographic performance related to retention time and reproducibility. The preferred embodiment coordinates the injection run with active pressure control of a binary solvent delivery system to virtually eliminate the customary pressure drop when the low-pressure loop is brought on line. An additional benefit that enhances reproducibility is accomplished by forcing a consistent timing relationship between the injection run, the mechanical position of the delivery pump pistons, and the start and subsequent gradient delivery.Type: ApplicationFiled: February 25, 2011Publication date: August 18, 2011Applicant: Waters Technologies CorporationInventors: Stanley P. Pensak, JR., John Heden, Steven J. Ciavarini, John Lamoureux, Miguel Soares
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Patent number: 7917250Abstract: Systems, devices, and methods to mitigate the pressure disturbance associated with the injection of low-pressure analyte samples into a high-pressure HPLC fluid stream to enhance chromatographic performance related to retention time and reproducibility. The injection event is coordinated with active pressure control of a binary solvent delivery system to virtually eliminate the customary pressure drop when the low-pressure loop is brought on line. Consistent timing with the injection event of the mechanical position of the delivery pump pistons, and the start and subsequent gradient delivery generates reproducible results.Type: GrantFiled: August 19, 2005Date of Patent: March 29, 2011Assignee: Waters Technologies CorporationInventors: Stanley P. Pensak, Jr., John Heden, Steven J. Ciavarini, John Lamoureux, Miguel Soares
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Publication number: 20090062966Abstract: Systems, devices, and methods to mitigate the pressure disturbance associated with the injection of low-pressure analyte samples into a high-pressure HPLC fluid stream (52), to enhance chromatographic performance related to retention time and reproducibility. The preferred embodiment coordinates the injection run with active pressure control of a binary solvent delivery system (30) to virtually eliminate the customary pressure drop when the low-pressure loop is brought on line. An additional benefit that enhances reproducibility is accomplished by forcing a consistent timing relationship between the injection run, the mechanical position of the delivery pump pistons, and the start and subsequent gradient delivery.Type: ApplicationFiled: August 19, 2005Publication date: March 5, 2009Applicant: WATERS INVESTMENTS LIMITEDInventors: Stanley P. Pensak, JR., John Heden, Steven J. Ciavarini, John Lamoureux, Miguel Soares