Abstract: Described are polymeric microparticles, compositions and method of making and using. The polymeric microparticles can include a polymeric core comprising a first polymer and an active agent susceptible to abuse; and a polymeric shell comprising a second polymer.

Abstract: The present disclosure relates to compositions, devices, and methods for delivery of protein therapeutics, e.g., intravitreal delivery of a protein therapeutic to the eye. In particular, the present disclosure describes drug-delivery devices for injection into the eye of a subject in need thereof comprising a capsule having a bi-layered wall and a therapeutic agent, wherein the therapeutic agent is initially present within a luminal space of the capsule. Methods of making and using these drug-delivery devices are also described.

Abstract: Nanofiber-based sensors for the rapid detection, identification, and/or quantification of analytes, including gaseous analytes such as oxygen, are provided. The nanofiber-based sensors can comprise core-shell nanofibers. The core-shell nanofibers can comprise (a) a core comprising a first polymer and an sensor dispersed therein; and (b) a shell disposed coaxially around the core, comprising a second polymer.

Abstract: Nanofiber-based sensors for the rapid detection, identification, and/or quantification of analytes, including gaseous analytes such as oxygen, are provided. The nanofiber-based sensors can comprise core-shell nanofibers. The core-shell nanofibers can comprise (a) a core comprising a first polymer and an sensor dispersed therein; and (b) a shell disposed coaxially around the core, comprising a second polymer.

Abstract: Nanofiber-based sensors for the rapid detection, identification, and/or quantification of analytes, including gaseous analytes such as oxygen, are provided. The nanofiber-based sensors can comprise core-shell nanofibers. The core-shell nanofibers can comprise (a) a core comprising a first polymer and an sensor dispersed therein; and (b) a shell disposed coaxially around the core, comprising a second polymer.

Abstract: In an aspect, provided is an apparatus for sorting cells. The device may include polymer nanofibers treated with gaseous plasma. The nanofibers may comprise at least one of polycaprolactone and collagen. The gaseous plasma may comprise at least one of CF4, oxygen, argon, nitrogen, and air. In a further aspect, provided are methods of sorting cells in a composition. The method may include providing a substrate comprising polymer nanofibers that have been pretreated with a gaseous plasma, contacting the polymer nanofibers with a composition comprising a plurality of cells, and applying a force to the polymer nanofibers. In another aspect, provided are methods of making a device for sorting cells. The method may include applying a composition comprising at least one polymer onto a surface by electrospinning to form polymer nanofibers, and exposing the polymer nanofibers to a gaseous plasma to produce treated polymer nanofibers.