Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.

Abstract: Antibodies and antigen binding fragments that specifically bind to ebolavirus glycoprotein and neutralize ebolavirus infection are disclosed. Nucleic acids encoding these antibodies, vectors, and host cells are also provided. The disclosed antibodies, antigen binding fragments, nucleic acids and vectors can be used, for example, to inhibit an ebolavirus infection in a subject.

Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Abstract: Aspects of the present disclosure relate generally to methods, compositions, and kits for in situ whole cell or single cell barcoding. Aspects of the present disclosure also include a computer readable-medium and a processor to carry out the steps of the method described herein. In some embodiments, the disclosure relates to whole cell or single cell barcoding performed in situ.

Abstract: In a preferred embodiment, there is provided a method for reducing power consumption in an artificial neural network, the method comprising: receiving an input signal; modulating a sampling frequency of an artificial neuron based on the input signal; and forwarding the input signal or a further input signal obtained from the input signal to the artificial neuron at the sampling frequency, wherein said modulating the sampling frequency comprises increasing the sampling frequency with an increased input signal and reducing the sampling frequency with a decreased input signal.

Abstract: The present invention provides the use of lipocalin 2 (LCN2) as a biomarker for IL-17 mediated diseases and for monitoring the response of a patient to anti-IL-17 therapy.

Abstract: The present application provides a reinforced carton. The reinforced carton may include a number of first panels, a number of adjoining second panels, and with the first panels including one or more strength enhancing features. The one or more strength enhancing features may include a vertical fold line extending across the first panels.

Abstract: Centrifuge vessels suitable for live cell processing include a bowl with a cap, and a tube inside the bowl extending between the cap and a lower portion of the bowl. The bottom of the bowl can have a closed annular ring surrounding a center mound. The vessels can be particularly suitable for processing low volumes of live cells for vaccines or other therapies.

Abstract: A SAW sensor arrangement includes a transducer including a support for supporting a SAW device. The support includes a sensor location part located between two oppositely extending attachment parts. The SAW device is mountable to the sensor location part. The sensor arrangement 10 includes at least two spaced friction raisers. The sensor arrangement includes a clamp arrangement which applies a clamping force to clamp the sensor arrangement to an item. The sensor arrangement is arranged so that in use each of the friction raisers is located between a different one of the attachment parts and the item.

Abstract: In various embodiments, a data integration system is disclosed which enables users to create a logical design which is platform and technology independent. The user can create a logical design that defines, at a high level, how a user wants data to flow between sources and targets. The tool can analyze the logical design, in view of the user's infrastructure, and create a physical design. The logical design can include a plurality of components corresponding to each source and target in the design, as well as operations such as joins or filters, and access points. Each component when transferred to the physical design generates code to perform operations on the data. Depending on the underlying technology (e.g., SQL Server, Oracle, Hadoop, etc.) and the language used (SQL, pig, etc.) the code generated by each component may be different.

Abstract: A data integration system is disclosed that incorporates one or more techniques for simplifying the design and maintenance of a mapping. As components are added or removed to an existing design, the data integration system removes the need to specify all input and output attributes. In one aspect, components types are implemented that allow assignment expressions to reference all or part of upstream components. Therefore, attributes of certain types of components can be propagated to downstream components or otherwise inherited from upstream components with minimal effort on the part of a map designer. During code generation the attributes required to be projected by any component can be derived based on the needs of the downstream components.

Abstract: The present application provides an automated beverage dispenser for use with a number of cups. The automated beverage dispenser may include a carousel with a number of shelves, a first actuator such that first actuator may maneuver the shelves in a first direction, a second actuator positioned adjacent to the carousel, and a gripper positioned on the second actuator such that the second actuator may maneuver one of the cups by the gripper in a second direction to one of the shelves of the carousel.

Abstract: The present application provides a reinforced carton. The reinforced carton may include a number of first panels, a number of adjoining second panels, and with the first panels including one or more strength enhancing features. The one or more strength enhancing features may include a vertical fold line extending across the first panels.

Abstract: A SAW sensor arrangement includes a transducer including a support for supporting a SAW device. The support includes a sensor location part located between two oppositely extending attachment parts. The SAW device is mountable to the sensor location part. The sensor arrangement 10 includes at least two spaced friction raisers. The sensor arrangement includes a clamp arrangement which applies a clamping force to clamp the sensor arrangement to an item. The sensor arrangement is arranged so that in use each of the friction raisers is located between a different one of the attachment parts and the item.

Abstract: Centrifuge vessels suitable for live cell processing include a bowl with a cap, and a tube inside the bowl extending between the cap and a lower portion of the bowl. The bottom of the bowl can have a closed annular ring surrounding a center mound. The vessels can be particularly suitable for processing low volumes of live cells for vaccines or other therapies.

Abstract: In various embodiments, a data integration system is disclosed which enables users to create a logical design which is platform and technology independent. The user can create a logical design that defines, at a high level, how a user wants data to flow between sources and targets. The tool can analyze the logical design, in view of the user's infrastructure, and create a physical design. The logical design can include a plurality of components corresponding to each source and target in the design, as well as operations such as joins or filters, and access points. Each component when transferred to the physical design generates code to perform operations on the data. Depending on the underlying technology (e.g., SQL Server, Oracle, Hadoop, etc.) and the language used (SQL, pig, etc.) the code generated by each component may be different.

Abstract: A data integration system is disclosed that incorporates one or more techniques for simplifying the design and maintenance of a mapping. As components are added or removed to an existing design, the data integration system removes the need to specify all input and output attributes. In one aspect, components types are implemented that allow assignment expressions to reference all or part of upstream components. Therefore, attributes of certain types of components can be propagated to downstream components or otherwise inherited from upstream components with minimal effort on the part of a map designer. During code generation the attributes required to be projected by any component can be derived based on the needs of the downstream components.

Abstract: Medicament devices include a sealed medicament dose container comprising a cell based medicament that is stored at a temperature less than about ?40 degrees Celsius, then thawed into a liquid prior to administration and a medicament dose cartridge configured and sized to snugly hold the dose container therein during extraction of the liquid medicament. Related dose containers, retainers and extraction/dispensing systems are also described.

Abstract: The present application provides an automated beverage dispenser for use with a number of cups. The automated beverage dispenser may include a carousel with a number of shelves, a first actuator such that first actuator may maneuver the shelves in a first direction, a second actuator positioned adjacent to the carousel, and a gripper positioned on the second actuator such that the second actuator may maneuver one of the cups by the gripper in a second direction to one of the shelves of the carousel.