Abstract: Compositions comprising proanthocyanidin compositions (e.g. those extracted from cinnamomum species) that are observed to bind tau and inhibit its aggregation as well as methods for making and using such compositions are disclosed. In certain embodiments of the invention, the proanthocyanidins can be used as a probe to identify and/or characterize tau isoforms in a variety of contexts. In other embodiments of the invention, these compositions are used in methods designed to treat neurological disorders associated with tau aggregation (e.g. Alzheimer's disease).

Abstract: A resilient mount (30), such as a center bearing isolator mount includes an inner sleeve (52) into which is molded an elastomer/rubber isolator (60), and an insert (70). These components are prepared as a sub-assembly (50) and axially inserted into the opening of an outer bracket (32), whereby fingers (76) deflect radially during insertion and snap-fit radially outward once received through the bracket opening to preclude disassembly. A lower insertion force is required to assemble the components.

Abstract: An isolator assembly (20) such as a cradle mount or a body mount assembly incorporates break-away features. An insert (70,70?) includes a thinned cross-sectional region (100) or a gap/interface (90) between insert portions (70a, 70b) that allow a bolt (24) to break-away under a predetermined load in a fore direction (80) and an aft direction (90). In addition, a retainer washer (50) may have an irregular configuration such as a tear-drop or clover-leaf configuration that cooperates with the insert (70, 70?) to allow the isolator assembly (20) to pull away in the negative z-direction under a predetermined load.