Abstract: A phantom for quality assurance for stereotactic body radiation therapy, systems and methods are provided. In some embodiments, a phantom has a body including a peripheral ring potion defining a ring shaped peripheral film holder and a center portion defining a central axis film holder for receiving a radiochromic film.

Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Abstract: A process for removing Co2+, Pb2+, Cd2+ and Cr3+ toxins from bodily fluids is disclosed. The process involves contacting the bodily fluid with an ion exchange composition to remove the metal toxins in the bodily fluid, including blood and gastrointestinal fluid. Alternatively, blood can be contacted with a dialysis solution which is then contacted with the ion exchange composition. The ion exchange compositions are represented by the following empirical formula: AmZraTibSncMdSixOy. A composition comprising the above ion exchange compositions in combination with bodily fluids or dialysis solution is also disclosed. The ion exchange compositions may be supported by porous networks of biocompatible polymers such as carbohydrates or proteins.

Abstract: It is an object of the present invention to provide an antibody-drug conjugate of an antibody binding to DLL3 and a drug having antitumor activity, a pharmaceutical composition comprising the antibody-drug conjugate and having therapeutic effects on a tumor, a method for treating a tumor using the antibody-drug conjugate or the pharmaceutical composition, and the like. The present invention provides an antibody-drug conjugate of an antibody binding to DLL3 and a drug having antitumor activity, a pharmaceutical composition comprising the antibody or the antibody-drug conjugate, and a method for treating a tumor.

Abstract: The present invention provides a novel anti-DLL3 antibody-pyrrolodiazepine derivative and a novel anti-DLL3 anti-body-pyrrolodiazepine derivative conjugate using the same.

Abstract: Systems and methods for efficiently managing bulk material are provided. The disclosure is directed to a portable support structure used to receive one or more portable containers of bulk material and output bulk material from the containers directly into the blender hopper. The portable support structure may include a frame for receiving and holding the one or more portable bulk material containers in an elevated position proximate the blender hopper, as well as one or more gravity feed outlets for routing the bulk material from the containers directly into the blender hopper. In some embodiments, the portable support structure may be transported to the well site on a trailer, unloaded from the trailer, and positioned proximate the blender unit. In other embodiments, the portable support structure may be a mobile support structure that is integrated into a trailer unit.

Abstract: Described herein are examples of evaluating electromagnetic energy reflection data of security scans. In embodiments, a method to evaluate electromagnetic energy reflection data determines whether electronic information of a security scan contains an anomaly, and identifies an anomaly location in the electronic information corresponding to the anomaly. The method determines a subset of the electronic information corresponding to the anomaly location, determines anomaly attributes using the subset of the electronic information, and evaluates the anomaly attributes using a database of reference items by comparing anomaly attributes to respective reference characteristics of reference items or identity information. When a comparison meets the respective match criterion for the given reference item, the method assigns to the anomaly the respective identifier as an anomaly identifier.

Abstract: The present disclosure relates to systems for the expression of antibodies or antigen binding fragments in a subject, as well as methods of treatments of diseases therewith.

Abstract: An example frequency converter includes a drift canceling loop with a balanced delay and a linear signal path (e.g., linear with respect to frequency scaling, amplitude modulation, and/or phase modulation). One side of the drift canceling loop includes a fixed delay, and the opposite side includes an adjustable, complementary delay. The adjustable, complementary delay facilitates precision matching of the signal delays on each side of the loop over a range of frequencies, which results in a significant improvement in noise cancelation, particularly at large offsets to the carrier, while permitting the use of a higher noise, but very fast tuning course scale oscillator. The linear signal path from the signal generator to an RF output facilitates modulation of the signal by the signal generator. A modular format is an advantageous embodiment of the invention that includes the removal of the frequency synthesizer's low phase noise reference into a separate module.

Abstract: A blow molded article, a method of making a blow molded article and a method of making a preform each having at least one layer comprising a thermoplastic resin and between 0.1% and 20% of an additive having a viscosity of greater than 1,000,000 cst. There is a refractive index difference of at least 0.04 between the additive and the thermoplastic resin. The high viscosity of the additive ensures even distribution of the additive within the thermoplastic resin in discrete domains, while additionally providing for a complex end look balancing opacity, gloss and depth.

Abstract: Disclosed are a pick tip apparatus method interchanging pick tip assemblies within the same. The pick tip apparatus includes a housing having a housing channel. The apparatus further includes a fitting connected to the housing channel. The fitting is configured to accept an external vacuum source for applying a vacuum to the housing channel. The apparatus further includes a magnet and a pick tip assembly. The pick tip assembly is releasably held within the housing channel magnetically by the magnet. The pick tip assembly includes a vacuum cup and a pick tip body. The pick tip body has a pick tip body channel in communication with the housing channel and configured to apply the vacuum from the housing channel to the vacuum cup.

Abstract: Methods and systems for treating an olefin-containing stream are disclosed. The disclosed methods and systems are particularly suitable for treating an off-gas stream in a refining or petrochemical process, such as from a fluid catalytic cracker (FCC), coker, steam cracker, and the like. The stream is treated in an absorber column to reject lighter stream components and to absorb ethylene and/or propylene into a solvent. The solvent is typically isobutane. The enriched solvent stream from the absorber column is fed to an alkylation reactor, which reacts the dissolved olefin with the isobutane solvent to produce an alkylate product.

Abstract: Systems and methods for using one or more pre-filled, portable containers, instead of pneumatic transfer, to move bulk material from a transportation unit to a blender receptacle of a blender are provided. A transportation unit may deliver one or more containers of bulk material to the well site, where the containers may be disposed in an elevated position around the blender receptacle. A gravity feed outlet may extend from one or more containers to route bulk material from the one or more containers directly into the blender receptacle. Since the transportation unit is able to unload the portable containers of bulk material without pneumatic transfer, the stackable containers may enable a cleaner and more efficient bulk material transfer at the site.

Abstract: A robotic cleaning system may include a docking station, a robotic cleaner that includes at least one of a first set of robot charging contacts or a second set of robot charging contacts, the first and second sets of robot charging contacts being configured to electrically couple the robotic cleaner to the docking station, a dust cup configured to removably couple to the robotic cleaner, and a mop module configured to removably couple to the robotic cleaner. When the mop module is coupled to the robotic cleaner, the robotic cleaner may be configured to electrically couple to the docking station using the first set of robot charging contacts. When the mop module is not coupled to the robotic cleaner, the robotic cleaner may be configured to electrically couple to the docking station using the second set of robot charging contacts.

Abstract: An entity computing device associated with a service provider can temporarily provision access to a functionality associated with the service provider to user computing devices operated by users associated with the entity. In an example, the entity computing device can receive, via an application, information from instances of the application executing on the user computing devices. Based on the information, the entity computing device can provision to a user computing device access to a functionality associated with the application. The access can enable the user computing device to independently implement the functionality via an instance of the application. Data corresponding to the usage of the functionality can be received by the entity computing device from the user computing device and can be sent by the entity computing device to the service provider to update database(s) associated with the functionality.

Abstract: A wheel-based generator system for a utility cart is provided. The wheel-based generator system includes a generator, an omni-directional wheel coupled to the generator and configured to drive the generator as the utility cart is pushed across a floor, and a regulator coupled to the generator. The generator is configured to transform mechanical energy from motion of the omni-directional wheel into electrical energy for charging one or more batteries of one or more electronic devices on the utility cart. The regulator is configured to control at least one of an output voltage of the generator and a polarity of the output voltage of the generator.

Abstract: Methods and systems for treating an olefin-containing stream are disclosed. The disclosed methods and systems are particularly suitable for treating an off-gas stream in a refining or petrochemical process, such as from a fluid catalytic cracker (FCC), coker, steam cracker, and the like. The stream is treated in an absorber column to reject lighter stream components and to absorb ethylene and/or propylene into a solvent. The solvent is typically isobutane. The enriched solvent stream from the absorber column is fed to an alkylation reactor, which reacts the dissolved olefin with the isobutane solvent to produce an alkylate product.

Abstract: Disclosed are a pick tip apparatus method interchanging pick tip assemblies within the same. The pick tip apparatus includes a housing having a housing channel. The apparatus further includes a fitting connected to the housing channel. The fitting is configured to accept an external vacuum source for applying a vacuum to the housing channel. The apparatus further includes a magnet and a pick tip assembly. The pick tip assembly is releasably held within the housing channel magnetically by the magnet. The pick tip assembly includes a vacuum cup and a pick tip body. The pick tip body has a pick tip body channel in communication with the housing channel and configured to apply the vacuum from the housing channel to the vacuum cup.

Abstract: Systems and methods for efficiently managing bulk material are provided. The disclosure is directed to a portable support structure used to receive one or more portable containers of bulk material and output bulk material from the containers directly into the blender hopper. The portable support structure may include a frame for receiving and holding the one or more portable bulk material containers in an elevated position proximate the blender hopper, as well as one or more gravity feed outlets for routing the bulk material from the containers directly into the blender hopper. In some embodiments, the portable support structure may be transported to the well site on a trailer, unloaded from the trailer, and positioned proximate the blender unit. In other embodiments, the portable support structure may be a mobile support structure that is integrated into a trailer unit.