Abstract: The present invention relates to a recombinant fusion protein comprising a fragment of the cardioprotective protein neuregulin-1 (NRG-1) fused to a monoclonal antibody (mAb) backbone and to a method of treating a disease or condition in a subject in need thereof comprising administering a therapeutically effective amount of the recombinant fusion protein or the pharmaceutical composition comprising the recombinant fusion protein disclosed herein.

Abstract: The present invention relates to a recombinant fusion protein comprising a fragment of the cardioprotective protein neuregulin-1 (NRG-1) fused to a monoclonal antibody (mAb) backbone and to a method of treating a disease or condition in a subject in need thereof comprising administering a therapeutically effective amount of the recombinant fusion protein or the pharmaceutical composition comprising the recombinant fusion protein disclosed herein.

Abstract: Virus and microbe-killing, self-sterilizing resistive heated air filters and methods of making and using same methods. The air filter is includes laser-induced graphene (LIG), a porous conductive graphene foam formed through photothermal conversion of a polyimide film (or another source or source of polymer or other LIG precursor material) by a laser source. The LIG in the air filter can capture particulates and bacteria. The bacteria cannot proliferate even when submerged in culture medium. Through a periodic Joule-heating mechanism, the filter easily reaches greater than 300° C.

Abstract: A wearable device includes a housing to encompass a portion of a body part, biometric sensors coupled to the housing, a controller coupled to the housing and biometric sensors, a communication channel for communicating with external devices and a temperature regulator to controllably adjust a temperature of the housing. The wearable device is configured to provide remote controlled heating and cooling of the body part. The wearable device may include an evaporative heat exchanger and a thermoelectric heat pump. The wearable device may provide means for dissipating heat through vaporization of a substance or using an advective flux and phase transition.

Abstract: An apparatus comprises a processing device that is configured to obtain information about driver installations of a given driver on a plurality of computing devices and to obtain information about system failures from the plurality of computing devices. The processing device is further configured to determine a correlation between the driver installations and the system failures and to determine that the given driver is likely to cause a system failure based at least in part on the determined correlation between the driver installations and the system failures. The processing device is further configured to provide an indication that the given driver is likely to cause a system failure to a given computing device. The indication is configured to cause the given computing device to inhibit a presentation of a recommendation to install the given driver to a user of the given computing device.

Abstract: A method for detecting and quantifying allergen components of a substance is described herein. A method can include obtaining an Ig sample derived from two or more individuals, and one or more capillaries comprising allergenic biologics adhered thereto. The Ig sample can be applied to the one or more capillaries and allergen component and molecules that has bound with the Ig sample, can be detected in the one or more capillaries. A molecular weight and/or frequency of appearance, an isoelectric charge and/or frequency of appearance, a molecular functional group and/or frequency of appearance or a combination thereof, of the allergen component can be recorded. Furthermore, methods for determining the minimum and maximum concentrations of the detected allergen components for pre-determined platforms, formulating an allergen product using the determined concentration ranges and applying the allergen product to result an effective assay are described.

Abstract: The present invention relates to a recombinant fusion protein comprising a fragment of the cardioprotective protein neuregulin-1 (NRG-1) fused to a monoclonal antibody (mAb) backbone and to a method of treating a disease or condition in a subject in need thereof comprising administering a therapeutically effective amount of the recombinant fusion protein or the pharmaceutical composition comprising the recombinant fusion protein disclosed herein.

Abstract: The present invention relates to a recombinant fusion protein comprising a fragment of the cardioprotective protein neuregulin-1 (NRG-1) fused to a monoclonal antibody (mAb) backbone and to a method of treating a disease or condition in a subject in need thereof comprising administering a therapeutically effective amount of the recombinant fusion protein or the pharmaceutical composition comprising the recombinant fusion protein disclosed herein.

Abstract: An isolated monoclonal antibody or an antigen-binding fragment that specifically binds human PD-1. A nucleic acid molecule encoding the antibody or the antigen-binding fragment, an expression vector, a host cell and a method for expressing the antibody or the antigen-binding fragment are also provided. The present invention further provides an immunoconjugate, a bispecific molecule, a chimeric antigen receptor, an oncolytic virus and a pharmaceutical composition comprising the antibody or the antigen-binding fragment, as well as a treatment method using an anti-PD-1 antibody of the invention.

Abstract: The present invention provides an isolated monoclonal antibody, or an antigen-binding portion thereof, specifically binding to CD40. The present invention further provides a pharmaceutical composition comprising the antibody, or the antigen-binding portion thereof, as well as a treatment method using the antibody or the antigen-binding portion thereof, or the pharmaceutical composition.

Abstract: Embodiments of the systems, methods, and computer readable medium devices disclosed herein provide a sentiment analysis system that can determine sentiment from an input of a user received from a device. Once the input is received, parsing and analysis can be performed to determine a particular sentiment corresponding to the input. The system can determine an overall sentiment of some or all of the users or viewers watching a particular video stream, such as a live video stream. The determined overall sentiment can represent a metric indicating what users generally feel about a portion of the video stream, and the system can use the determination to cause modification of the video stream or a future video stream to enhance the user experience.

Abstract: Intramedullary nails are provided for the fixation of epiphyseal fragments in a long bone of a patient in need thereof. The intramedullary nails have a cap portion that allows for fixation of the epiphyseal bone fragments thereto, and an intramedullary shaft for insertion into the medullary canal of the long bone. The intramedullary nails can provide for fixation of comminuted fractures that are difficult to treat with conventional methods. In some aspects, the patient is a human patient and the fracture is a Mason type II radial head fracture or a Mason type III radial head fracture. Methods of fixation of epiphyseal fractures using the intramedullary nails of the present disclosure are also described.

Abstract: The present invention relates to a recombinant fusion protein comprising a fragment of the cardioprotective protein neuregulin-1 (NRG-1) fused to a monoclonal antibody (mAb) backbone and to a method of treating a disease or condition in a subject in need thereof comprising administering a therapeutically effective amount of the recombinant fusion protein or the pharmaceutical composition comprising the recombinant fusion protein disclosed herein.

Abstract: The present invention relates to anti-HER2 binding molecules (e.g., antibodies and antigen binding fragments thereof), derived HER2-binding molecules (e.g., bispecific anti-HER2 antibodies), and antibody-drug conjugates (ADC) that bind the extracellular domain of the HER2 receptor. Also provided are pharmaceutical formulation comprising the disclosed compositions and method for the treating diseases associated with HER2-mediated signal transduction.

Abstract: This disclosure provides a high precision measurement system for rapid, accurate determination of height of a deposition source relative to a deposition target substrate. In one embodiment, each of two transport paths of an industrial printer mounts a camera and a high precision sensor. The cameras are used to achieve registration between split transport axes, and the positions of the high precision sensors are each precisely determined in terms of xy position. One of the high precision sensors is used to measure height of the deposition source, while another measures height of the target substrate. Relative z axis position between these sensors is identified to provide for precise z-coordinate identification of both source and target substrate. Disclosed embodiments permit dynamic, real-time, high precision height measurement to micron or submicron accuracy.

Abstract: The present invention relates to anti-HER2 binding molecules (e.g., antibodies and antigen binding fragments thereof), derived HER2-binding molecules (e.g., bispecific anti-HER2 antibodies), and antibody-drug conjugates (ADC) that bind the extracellular domain of the HER2 receptor. Also provided are pharmaceutical formulation comprising the disclosed compositions and method for the treating diseases associated with HER2-mediated signal transduction.

Abstract: Described herein are a method and apparatus including calculating an aggregate peak total traffic demand for all overlapping access points in an interference range, comparing the aggregate peak total traffic demand to a threshold, rejecting a requested new quality of service traffic stream responsive to results of the comparison, calculating a peak total traffic demand for each overlapping access point in the interference range if the requested new quality of service traffic stream is admissible responsive to results of the comparison, comparing the peak total traffic demand for each overlapping access point in the interference range, if the requested new quality of service traffic stream is admissible, to the threshold and one of accepting the requested new quality of service traffic stream and rejecting the requested new quality of service traffic stream responsive to results of the second comparison.

Abstract: A receiver circuit comprising first and second antennas; an input amplification stage comprising first and second input amplifier circuits for amplifying first and second signals received at the first and second antennas respectively; a switching stage comprising first and second transconductance components connected respectively to the first and second input amplifier circuits and to a common output, and a switching mechanism arranged to selectively turn on and off the first and second transconductance components so that only one of the first and second transconductance components is in an on state at any time, the first and second transconductance components further amplifying the first and second signals respectively when in an on state; and an output amplification stage connected to the common output of the switching stage and comprising an output amplifier circuit for further amplifying the first and second signals when they are outputted via the common output.

Abstract: A device includes a substrate with a device region surrounded by an isolation region, in which the device region includes edge portions along a width of the device region and a central portion. The device further includes a gate layer disposed on the substrate over the device region, in which the gate layer includes a graded thickness in which the gate layer at edge portions of the device region has a thickness TE that is different from a thickness TC at the central portion of the device region.

Abstract: A bladed tool includes a handle and a blade with a surface-engaging edge and a blade-retaining shank. The handle includes an elongated handle body having longitudinally opposed body front and rear ends, and at least one side wall extending between the body front and rear ends. The side wall defines an outer surface configured for gripping by a user and an inner surface that defines an interior access channel extending from an access opening in the body rear end toward a forward channel wall located to the rear of the body front end. Situated between the body front end and the forward channel wall is a handle core that defines a shank-retaining slot extending between a forward slot-opening in the body front end and a rearward slot-opening in the forward channel wall. The shank extends rearwardly through the shank-retaining slot such that a protruding shank portion extends to the rear of the forward channel wall.