Abstract: Thienopyridone compounds of formula (I): or a salt thereof, pharmaceutical compositions containing such compounds and their use in therapy, in particular in the treatment of diseases or conditions for which a bromodomain inhibitor is indicated.

Abstract: Thienopyridone compounds of formula (I): or a salt thereof, pharmaceutical compositions containing such compounds and their use in therapy, in particular in the treatment of diseases or conditions for which a bromodomain inhibitor is indicated.

Abstract: The present invention provides compounds of formula (I); pharmaceutically acceptable salts and N-oxides thereof in which A, B, D and E are C or N with the proviso that one or more are N, R1, R2, R3, R4, R5 and R6 are simple substituents, n is 0-3 and y is an aryl, heteroaryl, carbocyclyl or fused-carbocyclyl group; as VR-1 antagonists for treating conditions or diseases in which pain and/or inflammation predominates; the use of the same for manufacturing medicaments, pharmaceutical compositions comprising them and methods of treatment utilizing them

Abstract: This invention pertains generally to the field of multivariate statistics, and in particular to new methods for the analysis (e.g., chemometrics) of chemical, biochemical, and biological data, including, for example, spectral data, including but not limited to nuclear magnetic resonance (NMR) spectral data. These methods are useful, for example, in metabonomics, proteomics, transcriptomics, genomics, etc., and form a part of other methods, for example, methods for the identification of chemical species, methods for the identification of biomarkers that are useful in methods of classification, diagnosis, prognosis, etc.

Abstract: This invention pertains to chemometric methods for the analysis of chemical, biochemical, and biological data, for example, spectral data, for example, nuclear magnetic resonance (NMR) spectra, and their applications, including, e.g., classification, diagnosis, prognosis.

Abstract: A method of generating models with which to characterise selected aspects of the metabolic phenotype of subjects without dosing a test substance to those subjects or with which to predict, without dosing, the post-dose responses of subjects where those responses are dependent on metabolic phenotype, the method comprising: obtaining pre-dose data relating to a plurality of subjects before dosing with a dosing substance; obtaining post-dose data relating to the plurality of subjects after dosing with the dosing substance; and correlating inter-subject variation in the pre-dose data with inter-subject variation in the post-dose data, and generating a pre-to-post-dose predictive model on the basis of the observed correlation. The models may be used to determine selected aspects of the metabolic phenotype of a subject or to predict, without dosing, the post-dose responses of subjects.

Abstract: This invention pertains to chemometric methods for the analysis of chemical, biochemical, and biological data, for example, spectral data, for example, nuclear magnetic resonance (NMR) spectra, and their applications, including, e.g., classification, diagnosis, prognosis, etc., especially in the context of bone disorders, e.g., conditions associated with low bone mineral density, e.g., osteoporosis.

Abstract: An optimal mineralized potable or drinking water formulation. This optimal mineralized drinking water formulation has great utility in preventing cardiovascular disease and improved blood glucose levels, and related blood conditions, and is an aqueous solution consisting essentially of:0.01-0.08 mg/liter Chromium ions;30-100 mg/liter Magnesium ions;30-125 mg/liter Calcium ions;0.06-0.15 mg/liter Lithium ions; and10-100 mg/liter Potassium ions.All the chemical elements are present in the ionic form as water soluble salts, e.g., as sulfates, nitrates, or chlorides or other salts of the elements. The mineral water contains no sodium ions. The minerals can also be in a kit form for adding to water by an end user.

Abstract: This invention is directed to an optimal mineralized potable or drinking water formulation. The optimal mineralized drinking i.e., potable, water formulation strongly appears to have great utility in preventing cardiovascular disease and is an aqueous solution consisting essentially of:20-40 mg/liter Strontium ions;50-100 mg/liter Magnesium ions;60-125 mg/liter Calcium ions; and0.06-0.15 mg/liter Lithium.All the chemical elements are present in the ionic form as water soluble salts, e.g., as sulfates, nitrates, or chlorides of the elements. The mineral water contains no sodium or potassium ions.