Abstract: The invention provides a method of treating a tumor in a human patient comprising (i) identifying a patient as having a LAG-3 positive tumor and (ii) administering to the patient a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor, or an anti-CTLA4 antibody. In some embodiments, the method further comprises identifying the patient as having a LAG-3 positive PD-L1 positive tumor. In some embodiments, the LAG-3 inhibitor is an anti-LAG-3 antibody and the PD-1 pathway inhibitor is an anti-PD-1 antibody. The methods of the invention can improve response rates to treatment with a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, or a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor.

Abstract: The disclosure is generally directed to a metal foam element configured to provide a multi-purpose functionality to an electrical device in a vehicle. An example apparatus in a vehicle includes a module that houses an electrical device. A metal foam element is attached to the module in a configuration whereby the metal foam element provides a multi-purpose functionality that includes a heat dissipation functionality and an antenna functionality. In an example implementation, the metal foam element is attached to the module in the form of a sheet that is dimensioned to operate as a patch antenna for transmitting and/or receiving a wireless signal associated with the electrical device and to provide a heat dissipation functionality for dissipating heat produced by the electrical device.

Abstract: The disclosure is generally directed to a metal foam element configured to provide a multi-purpose functionality to an electrical device in a vehicle. An example apparatus in a vehicle includes a module that houses an electrical device. A metal foam element is attached to the module in a configuration whereby the metal foam element provides a multi-purpose functionality that includes a heat dissipation functionality and an antenna functionality. In an example implementation, the metal foam element is attached to the module in the form of a sheet that is dimensioned to operate as a patch antenna for transmitting and/or receiving a wireless signal associated with the electrical device and to provide a heat dissipation functionality for dissipating heat produced by the electrical device.

Abstract: A vehicle includes at least one and/or one or more in-vehicle and/or onboard controller(s) that is/are coupled to spaced apart sensor groups that are arrayed within a headliner and/or seats of the vehicle cabin. Each sensor group generally corresponds to and/or with a plurality of and/or one or more seat positions, each having a single seat, and which include a driver zone seat position that has a driver seat. Each sensor group in the array includes at least one signal processor, and a plurality of transceivers, antennas, and/or sensors configured for and tuned to different electromagnetic frequencies and/or powers. Also included are electromagnetically active, directional waveguides that adjust, amplify, and/or attenuate the sensitivity of each of the respective antennas, to electromagnetic energy detected and received from mobile devices located in the vehicle cabin, such that the sensitivity is limited to electromagnetic emissions within a limited effective range for each antenna.

Abstract: A training apparatus having a base and an upright collision surface which is configured to pivot relative to the base about a transverse axis or configured in relation to the base to provide at least one predetermined limited degree of freedom of movement between the base and the collision surface and/or configured to rotate about an upright axis provides enables development of improved technique for collisions in contact sports such as American Football. The collision surface being is moveable and/or rotatable relative to the base mimics, in a controlled environment, a common configuration of a collision, whereby players can train on the most effective collision techniques, including enhancing power and strength direction of approach and, maintaining power at a required height against a contact surface arranged at a predetermined angle.

Abstract: A vehicle includes at least one and/or one or more in-vehicle and/or onboard controller(s) that is/are coupled to spaced apart sensor groups that are arrayed within a headliner and/or seats of the vehicle cabin. Each sensor group generally corresponds to and/or with a plurality of and/or one or more seat positions, each having a single seat, and which include a driver zone seat position that has a driver seat. Each sensor group in the array includes at least one signal processor, and a plurality of transceivers, antennas, and/or sensors configured for and tuned to different electromagnetic frequencies and/or powers. Also included are electromagnetically active, directional waveguides that adjust, amplify, and/or attenuate the sensitivity of each of the respective antennas, to electromagnetic energy detected and received from mobile devices located in the vehicle cabin, such that the sensitivity is limited to electromagnetic emissions within a limited effective range for each antenna.

Abstract: A fob includes a case, an antenna, at least one input device, and a positioning element. The case has an interface portion and a handle portion. The antenna is disposed at the interface portion of the case. The input device is disposed on the interface portion of the case. The finger positioner orients a user's hand on the handle portion of the case away from the antenna.

Abstract: A method for adjusting a power setting of a key fob includes receiving an input signal from a sensor by a processor. The processor determines, based at least in part on the input from the sensor, that a person is holding the key fob. Based on the determination that the person is holding the key fob, the processor adjusts an initial power setting of the key fob by a predetermined amount.

Abstract: A fob includes a case, an antenna, at least one input device, and a positioning element. The case has an interface portion and a handle portion. The antenna is disposed at the interface portion of the case. The input device is disposed on the interface portion of the case. The finger positioner orients a user's hand on the handle portion of the case away from the antenna.

Abstract: A method for adjusting a power setting of a key fob includes receiving an input signal from a sensor by a processor. The processor determines, based at least in part on the input from the sensor, that a person is holding the key fob. Based on the determination that the person is holding the key fob, the processor adjusts an initial power setting of the key fob by a predetermined amount.

Abstract: A method comprising for adjusting a power level in a key fob includes transmitting a first output signal at a first power setting. A feedback signal is received via a feedback mechanism that indicates a first power level of the first output signal. The first output level is compared to a threshold level. A second output signal at a second power setting greater than the first power setting is transmitted if the first output power level is below the threshold.

Abstract: Provided are a method, apparatus and a computer program for managing message queues. Message streaming is enabled in a transactional messaging system that supports priority ordering of messages, without the need for complex locking mechanisms. Any messages which are transferred from a message queue to a message consumer after the message consumer initiates commit processing are replaced on the message queue at an appropriate position ahead of other messages. As part of commit processing, the consumer sends back to the manager of the message queue an identification of messages delivered to it before the commit, and this list of messages is extracted and compared with a message log to identify undelivered messages. Successfully delivered and committed messages can be committed by the queue manager, and undelivered messages can be replaced on the queue. A special high priority is assigned to the replaced messages to place them ahead of other messages.

Abstract: Provided are a method, apparatus and a computer program for managing message queues. Message streaming is enabled in a transactional messaging system that supports priority ordering of messages, without the need for complex locking mechanisms. Any messages which are transferred from a message queue to a message consumer after the message consumer initiates commit processing are replaced on the message queue at an appropriate position ahead of other messages. As part of commit processing, the consumer sends back to the manager of the message queue an identification of messages delivered to it before the commit, and this list of messages is extracted and compared with a message log to identify undelivered messages. Successfully delivered and committed messages can be committed by the queue manager, and undelivered messages can be replaced on the queue. A special high priority is assigned to the replaced messages to place them ahead of other messages.

Abstract: The present invention pertains to a dye-based inkjet ink set and, more particularly, to a dye-based inkjet ink set suitable for printing on polyamide fabric.

Abstract: Marine craft has a crushable frontal impact protection structure, comprising transverse bulkhead protecting passenger area; longitudinal crushable tubes; and transverse member. Webs and strengthen tubes, which may be made of extruded, heat treated aluminum; stainless steel; or plastic. Tubes in FIGS. 5 to 7 are splayed, to improve protection against angled impacts C. The forward ends of tubes are tapered, (FIG. 3) to initiate deformation. Tubes may be hexagonal, round, or oval in cross-section. FIG. 8 shows longitudinal bulkheads, and transverse bulkhead in place of tubes. FIG. 9 shows longitudinal corrugated sheets; these may be mounted transversely. FIG. 10 shows how area filled with deformable cellular foam, to act as a buoyancy aid if hull is breached. Side and roar impact protection is also disclosed.

Abstract: A compliant spacer which, in use, is located between planar surfaces of two machine elements which are, in use, clamped together in an assembly, the spacer having a first generally planar face and a second oppositely facing generally planar face which is generally parallel to the first generally planar face, each of the first and second generally planar faces having a plurality of raised regions, the raised regions of the first face being offset with respect to the raised regions of the second face, so that as the two machine elements are clamped together with the spacer therebetween, the spacer deforms out of plane to maintain the clamping load in use, and each raised region including a bearing surface and edge regions where the raised region joins the respective planar face of the spacer, the bearing surface being generally planar and parallel to the first and second planar faces, and the edge regions of the raised regions melding smoothly into the respective planar face of the spacer without any sharp disc

Abstract: The present invention pertains to a dye-based inkjet ink set and, more particularly, to a dye-based inkjet ink set suitable for printing on polyamide fabric. The present invention also pertains to a method for printing a polyamide fabric with the dye-based inkjet ink set, and a polyamide fabric so printed.

Abstract: At least three beans, 2, 4, 6, are connected in at least two planes by means of a cruciform member 8. Rivets 30 are used to locate the joint while a bonding agent, which may be a structural adhesive or cold solder, sets. Cruciform arms 10 may be at ninety degree intervals; at least one arm may be deformed into, or extruded at, an alternative angle. The beams may be of aluminium; other metal; plastic, or composite material. More than one cruciform may be used in one joint (FIGS. 2, 3); arms 10 may be abbreviated to reduce the joint's bulk and mass. Plates 12, 14 may be used in opposition to a cruciform to strengthen and balance joints. The bonded joint may be used in the frame of a vehicle, particularly an amphibious vehicle. The cruciform member provides broad planar surfaces for a strong bonded joint, which is unlikely to peel.

Abstract: The system has three main parts. The first is a service providing audio and visual data downloaded for the user. The service provides a library of audio files including words, phrases and complete stories. The database of audio files can be updated. The second component is a software application for a user's computer. The application provides users with the software necessary to connect to the service, to provide personalizing information, select audio and visual files, purchase and download the files from the service. The third component is a device for playing the audio and visual files with the ability to display animated characters on a screen corresponding to the audio files being played. The screen has the ability to allow the user to color characters similar to a coloring book.

Abstract: Voice Enabled Personalized Documents are documents that are highly personalized to an audience of one. That is, we are creating one to one communication documents that are voice enabled. The overall concept is to take personalized documents that contain unique information to an individual and voice-enable them. By doing this, we open up several new forms of delivery of personalized documents to the audience of our customers. The product that we are planning to offer utilizes technology to produce and assemble personalized messages for each person in a group that is the target audience. The personalized documents that we produce will have audio that includes personal information, some examples of this are the persons name, membership information, information regarding activity with a group etc. With these messages we will provide highly personalized information to users using high quality speech that will be acceptable to the end audience.