Patents by Inventor John Loike

John Loike has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for stimulating human leukocytes to kill bacteria, yeast and fungi in biofilms that have formed in/on prosthetic devices, catheters, tissues and organs in vivo
    Publication number: 20050214279
    Abstract: The present invention provides a method for stimulating human leukocytes to kill microorganisms in biofilms. The invention also provides a methods, compositions and kits for treating or preventing a biofilm infection in a mammal comprising administering a therapeutically effective amount of a complement protein and one or more antibodies which bind to a bacterial, yeast, fungal, carbohydrate or lipid epitope present in the biofilm. Additionally, the invention provides methods, compositions and kits for treating biofilm infection in a mammal which comprises administering to the mammal a therapeutically effective amount of a complement protein and a conjugate composition. The invention also provides methods for determining Critical Neutrophil Concentration and Neutrophil Extraction Efficiency in a mammal.
    Type: Application
    Filed: September 17, 2004
    Publication date: September 29, 2005
    Inventors: Samuel Silverstein, Jeff Leid, Yongmei Li, John Loike, J. Costerton, Mark Shirtliff
  • A METHOD OF TREATING INFECTION OF SUTURES AND PROSTHETIC DEVICES
    Publication number: 20020114804
    Abstract: An agent capable of inhibiting signalling mediated by a &bgr;1 integrin cell surface receptor of leukocyte cells will treat a bacterial infection associated with a surface of a foreign body over and around which fibrin has been deposited, or a malignant tumor over and around which tenascin has been deposited. In addition, coating a foreign body with a fibrinolytic agent will prevent chronic bacterial infection associated with the surface of the foreign body. Furthermore, an agent capable of stimulating signalling mediated by a &bgr;1 integrin cell surface receptor of leukocyte cells will treat chronic inflammation.
    Type: Application
    Filed: October 22, 1998
    Publication date: August 22, 2002
    Inventors: JOHN LOIKE, SAMUEL C. SILVERSTEIN
  • Method of preventing and treating bacterial infection of sutures and prosthetic devices, and promoting ingress of leukocytes into tumor foci
    Patent number: 5843436
    Abstract: An agent capable of inhibiting signalling mediated by a .beta..sub.1 integrin cell surface receptor of leukocyte cells will treat a bacterial infection associated with a surface of a foreign body over and around which fibrin has been deposited, or a malignant tumor over and around which tenascin has been deposited. In addition, coating a foreign body with a fibrinolytic agent will prevent chronic bacterial infection associated with the surface of the foreign body. Furthermore, an agent capable of stimulating signalling mediated by a .beta..sub.1 integrin cell surface receptor of leukocyte cells will treat chronic inflammation.
    Type: Grant
    Filed: April 22, 1996
    Date of Patent: December 1, 1998
    Assignee: The Trustees of Columbia University, in the City of New York
    Inventors: John Loike, Samuel C. Silverstein