Patents by Inventor John M. Dagle

John M. Dagle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA molecules stabilized by modifications of the 3?-terminal phosphodiester linkage
    Patent number: 6197944
    Abstract: The use of oligodeoxynucleotides modified at the 3′-terminal internucleotide link as therapeutic agents by a method of hybridizing the modified oligonucleotide to a complementary sequence within a targeted mRNA and cleaving the mRNA within the RNA-DNA helix by the enzyme RNaseH to block the expression of the corresponding gene.
    Type: Grant
    Filed: June 29, 1994
    Date of Patent: March 6, 2001
    Assignee: Integrated DNA Technologies, Inc.
    Inventors: Joseph A. Walder, Roxanne Y. Walder, Paul S. Eder, John M. Dagle
  • Methods for decreasing the expression of specifically targeted genes
    Patent number: 5962425
    Abstract: The use of oligodeoxynucleotides modified at the 3'-terminal internucleotide link as therapeutic agents by a method of hybridizing the modified oligonucleotide to a complementary sequence within a targeted mRNA and cleaving the mRNA within the RNA-DNA helix by the enzyme RNaseH to block the expression of the corresponding gene.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: October 5, 1999
    Assignee: University of Iowa Research Foundation
    Inventors: Joseph A. Walder, Roxanne Y. Walder, Paul S. Eder, John M. Dagle
  • Methods for blocking the expression of specifically targeted genes
    Patent number: 5491133
    Abstract: The use of oligodeoxynucleotides modified at the 3'-terminal internucleotide link as therapeutic agents by a method of hybridizing the modified oligonucleotide to a complementary sequence within a targeted mRNA and cleaving the mRNA within the RNA-DNA helix by the enzyme RNaseH to block the expression of the corresponding gene.
    Type: Grant
    Filed: March 19, 1991
    Date of Patent: February 13, 1996
    Assignee: University of Iowa Research Foundation
    Inventors: Joseph A. Walder, Roxanne Y. Walder, Paul S. Eder, John M. Dagle