Patents by Inventor John M. Denu

John M. Denu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for determining protein binding specificity using peptide libraries
    Patent number: 9988665
    Abstract: A method for determining protein binding specificity using a screen of a peptide library is provided. The method can be used to determine binding specificity for human NAD+-dependent deacetylase SIRT1, and to identify the most efficiently deacetylated peptide sequences. The method can be also used to screen a combinatorial H4 histone N-terminal tail peptide library to examine the binding preferences of a ?-phos (S1) H4 antibody toward all known possible H4 histone modification states.
    Type: Grant
    Filed: August 12, 2011
    Date of Patent: June 5, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: John M. Denu, Adam L. Garske
  • Compositions and methods for modulating calcium flux, glucose homeostasis and apoptosis
    Patent number: 8440638
    Abstract: Compositions and methods are disclosed which are effective for modulating glucose homeostasis, calcium ion flux and cell death in target cells.
    Type: Grant
    Filed: July 20, 2005
    Date of Patent: May 14, 2013
    Assignees: Wisconsin Alumni Research Foundation, University of Washington
    Inventors: John M. Denu, Andrew M. Scharenberg
  • Methods for determining protein binding specificity using peptide libraries
    Patent number: 8119572
    Abstract: A method for determining protein binding specificity using a screen of a peptide library is provided. The method can be used to determine binding specificity for human NAD+-dependent deacetylase SIRT1, and to identify the most efficiently deacetylated peptide sequences. The method can be also used to screen a combinatorial H4 histone N-terminal tail peptide library to examine the binding preferences of a ?-phos (S1) H4 antibody toward all known possible H4 histone modification states.
    Type: Grant
    Filed: October 24, 2006
    Date of Patent: February 21, 2012
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: John M. Denu, Adam L. Garske
  • Methods for Determining Protein Binding Specificity Using Peptide Libraries
    Publication number: 20120040860
    Abstract: A method for determining protein binding specificity using a screen of a peptide library is provided. The method can be used to determine binding specificity for human NAD+-dependent deacetylase SIRT1, and to identify the most efficiently deacetylated peptide sequences. The method can be also used to screen a combinatorial H4 histone N-terminal tail peptide library to examine the binding preferences of a ?-phos (S1) H4 antibody toward all known possible H4 histone modification states.
    Type: Application
    Filed: August 12, 2011
    Publication date: February 16, 2012
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: John M. Denu, Adam L. Garske
  • Compositions and methods for identifying agents which regulate chromosomal stability, gene activation and aging
    Patent number: 7521432
    Abstract: Novel compositions and methods are provided for identifying agents which affect chromosomal stability and aging.
    Type: Grant
    Filed: April 25, 2007
    Date of Patent: April 21, 2009
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: John M. Denu, Kirk G. Tanner
  • Compositions and Methods for modulating Calcium Flux, Glucose Homeostasis and Apoptosis
    Publication number: 20080249059
    Abstract: Compositions and methods are disclosed which are effective for modulating glucose homeostasis, calcium ion flux and cell death in target cells.
    Type: Application
    Filed: July 20, 2005
    Publication date: October 9, 2008
    Inventors: John M. Denu, Andrew M. Scharenberg
  • Compositions and methods for identifying agents which regulate chromosomal stability, gene activation and aging
    Patent number: 7291606
    Abstract: Novel compositions and methods are provided for identifying agents which affect chromosomal stability and aging.
    Type: Grant
    Filed: November 13, 2001
    Date of Patent: November 6, 2007
    Assignee: Wisconson Alumni Research Foundation
    Inventors: John M. Denu, Kirk G. Tanner
  • O-acetyl-ADP-ribose non-hydrolyzable analogs
    Publication number: 20070225246
    Abstract: Compounds, compositions and methods for modulating cell death in target cells, particularly cancer cells are provided. The compounds are analogs of O-acetyl-ADP-ribose (OAADPr).
    Type: Application
    Filed: March 26, 2007
    Publication date: September 27, 2007
    Inventors: John M. Denu, Lindsay R. Comstock
  • Compositions and methods for identifying agents which regulate chromosomal stability, gene activation and aging
    Publication number: 20040067228
    Abstract: Novel compositions and methods are provided for identifying agents which affect chromosomal stability and aging.
    Type: Application
    Filed: November 3, 2003
    Publication date: April 8, 2004
    Inventors: John M. Denu, Kirk G. Tanner