Patents by Inventor John M. Vierling

John M. Vierling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • In vivo, animal model for expression of hepatitis C virus
    Patent number: 6034297
    Abstract: Disclosed is a method for expressing hepatitis C virus in an in vivo, animal model. Viable, hepatitis C virus-infected, human hepatocytes are transplanted into a liver parenchyma of a scid/scid mouse host. The scid/scid mouse host is then maintained in a viable state, for up to five days or greater, whereby viable, morphologically intact human hepatocytes persist in the donor tissue and hepatitis C virus is replicated in the persisting human hepatocytes.
    Type: Grant
    Filed: September 26, 1997
    Date of Patent: March 7, 2000
    Assignee: Cedars-Sinai Medical Center
    Inventor: John M. Vierling
  • Direct detection of hepatitis C virus RNA
    Patent number: 5914228
    Abstract: The methods and compositions of this invention provide a fast, accurate means for directly determining the presence and quantity of HCV in a sample, and thus in a patient, through hybridization to patient samples using a probe specific for HCV. They allow detection of both acute and chronic HCV infection. These methods and compositions also allow for the effective monitoring of therapeutic procedures for treating HCV infection.
    Type: Grant
    Filed: November 8, 1994
    Date of Patent: June 22, 1999
    Assignee: Cedars-Sinai Medical Center
    Inventors: John M. Vierling, Ke-Qin Hu