Patents by Inventor John M. Wages

John M. Wages has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-Marinobufagenin Antibodies and Uses Thereof
    Publication number: 20200347129
    Abstract: The present disclosure provides chimeric, humanized and human monoclonal antibodies (mAbs) and fragments thereof that specifically bind to marinobufagenin (MBG) with high affinity. The anti-MBG mAbs and fragments thereof can be used to treat MBG-associated disorders, including hypertensive disorders and fibrotic disorders, optionally in combination with an additional therapeutic agent. Furthermore, the anti-MBG mAbs and fragments thereof can be used for diagnostic purposes, including to detect MBG in biological samples and to diagnose MBG-associated disorders.
    Type: Application
    Filed: May 8, 2020
    Publication date: November 5, 2020
    Applicant: CTS Biopharma LLC
    Inventors: James W. Larrick, John M. Wages, Andrew R. Mendelsohn, Vikram Sharma, Bo Yu
  • Anti-marinobufagenin antibodies and uses thereof
    Patent number: 10654925
    Abstract: The present disclosure provides chimeric, humanized and human monoclonal antibodies (mAbs) and fragments thereof that specifically bind to marinobufagenin (MBG) with high affinity. The anti-MBG mAbs and fragments thereof can be used to treat MBG-associated disorders, including hypertensive disorders and fibrotic disorders, optionally in combination with an additional therapeutic agent. Furthermore, the anti-MBG mAbs and fragments thereof can be used for diagnostic purposes, including to detect MBG in biological samples and to diagnose MBG-associated disorders.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: May 19, 2020
    Assignee: CTS Biopharma LLC
    Inventors: James W. Larrick, John M. Wages, Andrew R. Mendelsohn, Vikram Sharma, Bo Yu
  • Anti-Marinobufagenin Antibodies and Uses Thereof
    Publication number: 20190389947
    Abstract: The present disclosure provides chimeric, humanized and human monoclonal antibodies (mAbs) and fragments thereof that specifically bind to marinobufagenin (MBG) with high affinity. The anti-MBG mAbs and fragments thereof can be used to treat MBG-associated disorders, including hypertensive disorders and fibrotic disorders, optionally in combination with an additional therapeutic agent. Furthermore, the anti-MBG mAbs and fragments thereof can be used for diagnostic purposes, including to detect MBG in biological samples and to diagnose MBG-associated disorders.
    Type: Application
    Filed: June 20, 2019
    Publication date: December 26, 2019
    Applicant: CTS Biopharma LLC
    Inventors: James W. Larrick, John M. Wages, Andrew R. Mendelsohn, Vikram Sharma, Bo Yu
  • Compositions and methods for using a solid support to purify DNA
    Patent number: 8598338
    Abstract: The present disclosure provides methods for isolating substantially pure and undegraded DNA from biological material via a solid support. The methods may use a DNA lysing solution that comprises a surfactant, a DNA-complexing salt (e.g., a lithium salt), and a buffer. Alternatively, the methods may use a solid support pre-treated with the DNA lysing solution.
    Type: Grant
    Filed: March 5, 2010
    Date of Patent: December 3, 2013
    Assignee: QIAGEN North American Holdings, Inc.
    Inventors: Robert Jackson Bair, Kristen Campbell Benedict, Wendy J. Kivens, Robert W. Kwiatkowski, Jr., Kim Paulsen, Daniel A. Strom, John M. Wages
  • Compositions and methods for using a solid support to purify RNA
    Patent number: 7893228
    Abstract: Reagents, methods and kits for the purification of RNA from biological materials are provided.
    Type: Grant
    Filed: October 12, 2001
    Date of Patent: February 22, 2011
    Assignee: Qiagen North American Holdings, Inc.
    Inventors: Ellen M. Heath, John M. Wages, Jr.
  • Compositions and methods for using a solid support to purify RNA
    Patent number: 7767804
    Abstract: Reagents, methods and kits for the purification of RNA from biological materials are provided.
    Type: Grant
    Filed: October 30, 2006
    Date of Patent: August 3, 2010
    Assignee: Qiagen North American Holdings, Inc.
    Inventors: Robert Jackson Bair, Jr., Ellen M. Heath, Heather Meehan, Kim Elayne Paulsen, John M. Wages, Jr.
  • COMPOSITIONS AND METHODS FOR USING A SOLID SUPPORT TO PURIFY DNA
    Publication number: 20100160619
    Abstract: Reagents, methods and kits for the purification of DNA from biological materials are provided.
    Type: Application
    Filed: March 5, 2010
    Publication date: June 24, 2010
    Applicant: Qiagen North American Holdings, Inc.
    Inventors: Robert Jackson Bair, Kristen Campbell Benedict, Wendy J. Kivens, Robert W. Kwiatkowski, JR., Kim Paulsen, Daniel A. Strom, John M. Wages
  • Compositions and methods for using a solid support to purify RNA
    Patent number: 7148343
    Abstract: Reagents, methods and kits for the purification of RNA from biological materials are provided.
    Type: Grant
    Filed: April 16, 2003
    Date of Patent: December 12, 2006
    Assignee: Gentra Systems, Inc.
    Inventors: Robert Jackson Bair, Jr., Ellen M. Heath, Heather Meehan, Kim Elayne Paulsen, John M. Wages, Jr.
  • Compositions and methods for using a solid support to purify RNA
    Publication number: 20040019196
    Abstract: Reagents, methods and kits for the purification of RNA from biological materials are provided.
    Type: Application
    Filed: April 16, 2003
    Publication date: January 29, 2004
    Inventors: Robert Jackson Bair, Ellen M. Heath, Heather Meehan, Kim Elayne Paulsen, John M. Wages
  • Compositions and methods for using a solid support to purify RNA
    Publication number: 20030073830
    Abstract: Reagents, methods and kits for the purification of RNA from biological materials are provided.
    Type: Application
    Filed: October 12, 2001
    Publication date: April 17, 2003
    Inventors: Ellen M. Heath, John M. Wages
  • Reagent and method for isolation and detection of selected nucleic acid sequences
    Patent number: 6060246
    Abstract: The invention relates to compositions and methods for rapidly detecting or isolating a target nucleic acid sequence in a polynucleotide-containing sample. The sample is exposed to a rapid pairing reagent, which contains a rapid capture component, effective to rapidly and non-selectively bind polynucleotides, and a target specific probe, effective to selectively bind the target nucleic acid sequence. Selectively disrupting the binding between the capture component and polynucleotides leaves only target sequence bound to the rapid pairing reagent.
    Type: Grant
    Filed: November 13, 1997
    Date of Patent: May 9, 2000
    Assignee: AVI BioPharma, Inc.
    Inventors: James E. Summerton, Dwight D. Weller, John M. Wages, Jr.