Abstract: The invention provides novel 1,2-diphenylethene derivatives and pharmaceutically acceptable salts thereof, the process for production of these compounds and their pharmaceutical composition and the use of these compounds as modulators of T-cells, neutrophils, macrophages and their associated cytokines as agents for treating immune, inflammatory and auto-immune diseases.

Abstract: The invention is drawn to novel macrolide compounds of formula I having antibiotic and antineoplastic activities, useful as medicaments and/or agrochemicals for microorganism infections, in particularly for infectious diseases involving drug-resistant Staphylococcus, and for treatment of human and animal cancers.

Abstract: The present invention provides novel methods of treating psoriasis, protein tyrosine kinase-associated disorders, inflammation, epidermal hyperproliferation, diabetes, immune and autoimmune diseases, eczema, and inflammatory bowel disease, inhibiting protein kinase, neutrophil activation, cell proliferation, tumour growth, metastasis, and the development of atheromatous plaque and restonosis, controlling angiogenesis, and preventing inflammatory bowel disease, using hydroxystilbenes and novel stilbene derivatives.

Abstract: The present invention provides pharmaceutical compositions containing hydroxystilbenes or their derivatives or analogues. The pharmaceutical compositions are useful for protein kinase inhibition, and for treatment of psoriasis, eczema and inflammation.

Abstract: The invention is drawn to novel macrolide compounds of formula I having antibiotic and antineoplastic activities, useful as medicaments and/or agrochemicals for microorganism infections, in particularly for infectious diseases involving drug-resistant Staphylococcus, and for treatment of human and animal cancers.

Abstract: The present invention provides novel diphenyl ethene compounds and pharmaceutically-acceptable salts thereof. Also provided are methods for making the compounds of the invention as well as methods for the use thereof in the treatment of immune, inflammatory, and auto-immune diseases.

Abstract: The present invention provides novel methods of treating psoriasis, protein tyrosine kinase-associated disorders, inflammation, epidermal hyperproliferation, diabetes, immune and autoimmune diseases, eczema, and inflammatory bowel disease, inhibiting protein kinase, neutrophil activation, cell proliferation, tumour growth, metastasis, and the development of atheromatous plaque and restonosis, controlling angiogenesis, and preventing inflammatory bowel disease, using hydroxystilbenes and novel stilbene derivatives.

Abstract: The present invention provides novel diphenyl ethene compounds and pharmaceutically-acceptable salts thereof. Also provided are methods for making the compounds of the invention as well as methods for the use thereof in the treatment of immune, inflammatory, and auto-immune diseases.

Abstract: The invention provides novel 1,2-diphenylethene derivatives and pharmaceutically acceptable salts thereof, the process for production of these compounds and their pharmaceutical composition and the use of these compounds as modulators of T-cells, neutrophils, macrophages and their associated cytokines as agents for treating immune, inflammatory and auto-immune diseases.

Abstract: Disclosed herein are compositions containing hydroxylstilbenes or their derivatives or analogues. The compositions are useful to inhibit protein kinease, and for the treatment of inflammatory diseases, including psoriasis, multiple sclerosis, rhumatoid arthritis, restinosis, inflammatory bowel disease, and inflammatory lung disease. They are also useful to treat surgical adhesions and graft rejection. Novel derivatives and analogues are also disclosed.

Abstract: The invention is drawn to novel antibiotics, XENORXIDES of formula shown below, wherein R1, R2=hydrogen, substituted or unsubstituted alkyl, cycloalkyl, acyl, aryl, aralkyl, or heterocyclyl group; R3=hydrogen, alkyl cycloalkyl, aralkyl or aryl group, produced by bacterial symbiont Xenorhabdus bovienii and/or other Xenorhabdus species, and/or by oxidation of the corresponding dithiolopyrrolone derivatives with oxygen and Xenorhabdus species, and/or its cell-free filtrate, the additional salts thereof, the compositions thereof and their use as medicaments and/or agrochemicals, particularly in the treatment of infectious diseases involving microorganisms susceptible to them, including drug-resistant Staphylococcus.

Abstract: The invention is drawn to a novel use of a group of known compounds with the formula shown below, ##STR1## wherein R.sub.1, R.sub.2 =hydrogen, substituted or unsubstituted alkyl, cycloalkyl, acyl, aryl, aralkyl, or heterocyclic group; R.sub.3 =hydrogen, alkyl, cycloalkyl, aralkyl, aryl or heterocyclic group, the salts thereof, the compositions thereof and their use as medicaments, particularly in the treatment of human and animal cancers.

Abstract: The invention is drawn to novel antibiotics, xenomins of the formula shown below, ##STR1## wherein R.sub.1 =hydrogen; R.sub.2 =an unsubstituted acyl group; R.sub.3 =hydrogen or alkyl, produced by Xenorhabdus species, the salts thereof, the compositions thereof and their use as medicaments and/or agrochemicals, particularly in the treatment of infectious diseases involving microorganisms susceptible to them, including drug-resistant Staphylococcus, and in the treatment of human and animal cancers.

Abstract: A system for non-destructively inspecting or testing for faults or damage in or beneath the surface of structures, such as debonds or delaminations in composite materials, or cracks, broken stringers, delaminations and the like in structures. High energy acoustic impulses are focused onto a sample point or local area for vibrationally exciting the surface of the structure under inspection. A laser Doppler camera system directs a laser beam onto the excited area and derives from reflected light energy information including time domain signals. A Fast Fourier Transform (FFT) is constructed for each sample point and an analysis made to set aside FFTs deviating from a preselected standard which represent damaged or other anomalous areas. The remaining FFTs represent an average or statistical FFT spectrum of the undamaged or fault-free area. The average FFTs and the deviating FFTs are then subtracted to provide a clear and unambiguous signal of the fault and other anomalous areas in the structure under test.

Abstract: Apparatus for non-destructively inspecting for faults in or beneath the surface of structures, such as debonds or delaminations in composite materials, or cracks, broken stringers, delaminations and the like in semi-monocoque structures, includes at least one spark gap discharge device displaced from the test object which focuses an acoustic pulse onto a small local area of the object for vibrationally exciting the surface of that area. A laser Doppler camera system, also displaced from the test object directs a laser beam onto the excited area and derives from light energy reflected back from the excited area the velocity of out-of-surface displacement of, and relaxation frequencies generated by, the surface of the excited area and provides an indication of whether a fault is present in that area.

Abstract: The invention is drawn to an antibiotic, NEMATOPHIN, 3-indoleethyl 3'-methyl-2-oxo-pentanamide (+stereoisomer, -stereoisomer and racemic mixture) and its derivatives, 3-indoleethyl 2-oxo-alkanamides, 3-indoleethyl 2-oxo-alkanoates with or without substitute(s) on the indole ring, produced by bacterial symbiont Xenorhabdus nematophilus and/or other Xenorhabdus species or synthesized by reaction of tryptamine or substituted tryptamine and 2-oxo-alkanoic acid or its derivative, the additional salts thereof, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them, including antibiotic-resistant Staphylococcus.

Abstract: Apparatus for non-destructively inspecting for faults in or beneath the surface of structures, such as debonds or delaminations in composite materials, or cracks, broken stringers, delaminations and the like in semi-monocoque structures, includes at least one spark gap discharge device displaced from the test object which focuses an acoustic pulse onto a small local area of the object for vibrationally exciting the surface of that area. A laser Doppler camera system, also displaced from the test object directs a laser beam onto the excited area and derives from light energy reflected back from the excited area the velocity of out-of-surface displacement of, and relaxation frequencies generated by, the surface of the excited area and provides an indication of whether a fault is present in that area.

Abstract: A semi-monocoque structure is nondestructively tested by affixing an exciter to the outer skin of the structure for causing it to vibrate with an out-of-plane motion in a nodal pattern. Sensors either attached to or spaced from the outer surface provide signals representative of phase and acceleration information at likely anti-nodal points from which a computer-programmed controller senses resonant frequencies and amplitude of displacement. The controller automatically scans the excitation frequency through a predetermined range, and upon sensing a resonant frequency examines the signal to ascertain phase and amplitude of displacement of the anti-nodes and automatically adjusts their amplitude of displacement until the anti-nodes are optimized to be either bi-concave or concave/convex.

Abstract: Methods and apparatus for automatically analyzing anti-nodal patterns formed in the outer skin of a semi-monocoque structure when it is excited to vibrate at a resonant frequency at which out-of-plane displacement is optimized. The described principles of analysis may be utilized to analyze a recorded image of the anti-nodal patterns obtained by holographic interferometry, or to directly examine the anti-nodal pattern by scanning a test area of the surface with a beam of coherent radiation, e.g., a laser beam, and utilizing the Doppler effect, measuring, recording and displaying a contour map showing out-of-plane displacement of the surface for analysis. In the holographic record case, comparison of the fringe density of the anti-nodes against the density of any fringes which may occur along normally fringe-free lines of underlying structure reveals the type and location of any structural faults.