Abstract: The present disclosure provides anti-CCR4 chimeric antigen receptors (CARs) and compositions and methods for modified immune cells or precursors thereof (e.g., modified T cells) comprising anti-CCR4 CARs. Also provided are methods of using the anti-CCR4 CAR-expressing cells to treat cancer and T cell-depleting systems for use in combination with anti-CCR4 CAR T cell therapy.

Abstract: A run flat system. The run flat system includes a run flat assembly and a continuous elastomeric cap member. The run flat assembly includes a plurality of arcuate shaped run flat segments which collectively form a ring, and the run flat assembly forms a noncompliant load bearing portion of the run flat system. The continuous elastomeric cap member covers a radially outer surface of the run flat assembly, and the continuous elastomeric cap member forms a compliant portion of the run flat system.

Abstract: Trigger routing in computational hardware such as a digital-signal processor involves routing a trigger signal from a first, master module to a second, slave module, thereby initiating an event at the slave module without involving a core processing unit.

Abstract: Trigger routing in computational hardware such as a digital-signal processor involves routing a trigger signal from a first, master module to a second, slave module, thereby initiating an event at the slave module without involving a core processing unit.

Abstract: A method for facilitating damping torsional or ring vibrations of a dynamoelectric machine including a rotor assembly with a first amortisseur bar and a second amortisseur bar extending therefrom and terminating at an endring is provided. The method includes providing a damping assembly, and positioning the damping between the first amortisseur bar and the second amortisseur bar such that the damping assembly contacts the first and second amortisseur bars, and is substantially proximate the endring or alternatively the damping assembly is positioned only over one amortisseur bar.

Abstract: A method for facilitating damping torsional or ring vibrations of a dynamoelectric machine including a rotor assembly with a first amortisseur bar and a second amortisseur bar extending therefrom and terminating at an endring is provided. The method includes providing a damping assembly, and positioning the damping between the first amortisseur bar and the second amortisseur bar such that the damping assembly contacts the first and second amortisseur bars, and is substantially proximate the endring or alternatively the damping assembly is positioned only over one amortisseur bar.

Abstract: The invention relates to a process for making compounds having fatty acid moieties by reacting a fatty acid with a (hydroxyalkyl)amino alkane acid or a (hydroxyalkyl)amine and an aqueous base followed by heating the reaction mixture. The process is particularly useful for the formation of di-fatty acid esters from BES, and tri-fatty acid esters from TES. The reaction parameters can be adjusted to produce useful additional products of the TES-trioleate, including fatty acid amides of mono-, di- and tri-oleoyl-TES.

Abstract: The present invention relates to cysteine protease inhibitors of the general formula (I): ##STR1## wherein Z is a cysteine protease binding moiety; X and Y are S, O or optionally substituted N; and R.sub.1 is optionally substituted alkyl or aryl.

Abstract: Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R.sup.1 is lower alkoxy or optionally substituted phenoxy;R.sup.2 is hydrogen, lower alkyl, optionally substituted phenyl or optionally substituted phenylalkyl;R.sup.3 is hydrogen, lower alkyl, lower alkoxy, halo, optionally substituted phenyl, optionally substituted phenyl-lower-alkyl or optionally substituted phenyl-lower-alkoxy, and m is 1 or 2;X and Y are different and are either R.sup.4 or --C(O)W whereinR.sup.4 is lower alkyl or optionally substituted phenyl-lower-alkyl;W is --OR.sup.5 or --NR.sup.6 R.sup.7,whereinR.sup.5 is alkyl, optionally substituted phenyl or optionally substituted benzyl; and R.sup.6 and R.sup.7 are independently hydrogen, lower alkyl, cycloalkyl or optionally substituted phenyl.The compounds of this invention are also useful for the treatment of disease-states caused by lipoxygenase activity in mammals, particularly 5-lipoxygenase activity, when administered systemically.

Abstract: Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R.sup.1 is lower alkoxy or optionally substituted phenoxy,R.sup.2 is the same as R.sup.1, or R.sup.2 is hydrogen, lower alkyl, optionally substituted phenyl or optionally substituted phenylalkyl,R.sup.3 is hydrogen, lower alkyl, lower alkoxy, halo, optionally substituted phenyl, optionally substituted phenyl-lower-alkyl or optionally substituted phenyl-lower-alkoxy, and m is 1 or 2;both X groups are the same and X is either --C(O)OR.sup.4 or --C(O)NR.sup.5 R.sup.6, whereinR.sup.4 is alkyl, phenyl or benzyl optionally substituted with one or two lower alkyl groups, lower alkoxy groups or halo; andR.sup.5 and R.sup.6 are independently hydrogen, lower alkyl, cycloalkyl or phenyl optionally substituted with one or two lower alkyl groups, lower alkoxy groups or halo.

Abstract: Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R.sup.1 is alkoxy, alkylthio, optionally substituted phenoxy or optionally substituted phenylthio;R.sup.2 is hydrogen, lower alkyl, optionally substituted phenyl or optionally substituted phenylalkyl;R.sup.3 is lower alkyl, lower alkoxy, or halo and m is 0, 1 or 2, or R.sup.3 is optionally substituted phenyl, optionally substituted phenyl lower alkyl, optionally substituted phenyl lower alkoxy, amino, lower alkylamino, lower dialkylamino, cyano, or S(0).sub.

Abstract: A dynamoelectric machine has a stator with a stator core and a plurality of spaced apart radially extending ventilation ducts. A rotor mounted for rotation within the stator has a shaft with a plurality of salient poles. Each salient pole has a winding on it and each pole with its winding constitutes a pole member. Adjacent pole members define between them an interpolar space. Cooling air enters each interpolar space from each end when the machine is operating, moves generally axially as portions of the air change direction to move radially outwards through the air gap separating the rotor and stator and then through the ventilation ducts. The air flow, in a radial outward direction, tends to be less at the ends of the rotor and through the ventilation ducts adjacent the ends of the stator. The invention places a baffle at each end of each interpolar space.

Abstract: Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R.sup.1 and R.sup.2 are the same and are lower alkoxy or optionally substituted phenoxy,R.sup.3 is lower alkyl, lower alkoxy, or halo and m is 0, 1 or 2 or R.sup.3 is optionally substituted phenyl, optionally substituted phenyl lower alkyl, optionally substituted phenyl lower alkoxy, amino, lower alkylamino, lower dialkylamino, cyano, or S(O).sub.n R wherein R is lower alkyl; optionally substituted phenyl; optionally substituted phenyl lower alkyl; or optionally substituted heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and the pharmaceutically acceptable acid addition salts thereof; and m is 1 and n is 0, 1 or 2;at least one of X or Y is C(O)W and the other X or Y is different and is hydrogen, C(O)W or R.sup.

Abstract: A circuit for use in conjunction with a multiplier receives a portion of completed product bits and a portion of sum and carry bits which, when accumulated, provide a complete output product operand. The circuit is adaptable for use with input operands having single or double precision data formats. The accumulation time required depends upon which data format mode the circuit is operating in.

Abstract: Novel alkoxycarbonylamino benzoates and related copounds (carbamoyl benzoates) are disclosed for treatment of auto-immune disease states, such as arthritis.

Abstract: Naphthalenes of the formula: ##STR1## wherein: m is 1 or 2;n is 1, 2, or 3;R.sup.1 is alkyl of one to seven carbon atoms or an optionally substituted phenyl;R.sup.2 is hydrogen, lower alkyl, lower alkoxy, optionally substituted phenyl, optionally substituted phenyl-lower-alkyl, optionally substituted phenyl-lower-alkoxy, amino, lower alkylamino, lower dialkylamino, halo, cyano, hydroxy, or lower alkylthio are useful in relieving psoriasis.

Abstract: A self-aligned gate structure for a compound semiconductor MESFET is formed rom a lower silicon layer and an upper metal, e.g. nickel, region. The nickel region forms an etch mask for the silicon and subsequently an implantation mask for the drain and source regions. Etching of the silicon provides an undercut whereby the gate separation from the drain and source is defined. Heating the structure to anneal the implant diffuses the metal into the silicon to form a compound silicide gate structure.

Abstract: Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R.sup.1 and R.sup.2 are the same and are lower alkoxy or optionally substituted phenoxy,R.sup.3 is lower alkyl, lower alkoxy, or halo and m is 0, 1 or 2 or R.sup.3 is optionally substituted phenyl, optionally substituted phenyl lower alkyl, optionally substituted phenyl lower alkoxy, amino, lower alkylamino, lower dialkylamino, cyano, or S(O).sub.n R wherein R is lower alkyl; optionally substituted phenyl; optionally substituted phenyl lower alkyl; or optionally substituted heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and the pharmaceutically acceptable acid addition salts thereof; and m is 1 and n is 0, 1 or 2;at least one of X or Y is C(O)W and the other X or Y is different and is hydrogen, C(O)W or R.sup.

Abstract: Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R.sup.1 and R.sup.2 are the same and are lower alkoxy, lower alkylthio, optionally substituted phenoxy or optionally substituted phenylthio,R.sup.3 is lower alkyl, lower alkoxy, or halo and m is 0, 1 or 2 or R.sup.3 is optionally substituted phenyl, optionally substituted phenyl lower alkyl, optionally substituted phenyl lower alkoxy, amino, lower alkylamino, lower dialkylamino, cyano, or S(O).sub.n R wherein R is lower alkyl; optionally substituted phenyl; optionally substituted phenyl lower alkyl; or optionally substituted heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and the pharmaceutically acceptable acid addition salts thereof; and m is 1 and n is 0, 1 or 2; andW is alkyl of one to seven carbon atoms, optionally substituted phenyl or optionally substituted benzyl.

Abstract: Psoriasis in mammals is relieved by topically administering naphthoquinones of the formula: ##STR1## wherein: R.sup.1 and R.sup.2 are lower alkoxy; andR.sup.3 is halo or cyano.