Abstract: A modular enclosure includes a plurality of enclosure modules, each of the enclosure modules comprising a front wall, a rear wall opposite the front wall, and two opposed side walls that span the front and rear walls; the front, rear and side walls forming an cavity; an equipment rack within the interior cavity with electronic equipment mounted thereon; and an air containment barrier that extends between the side walls to limit air flow between a front portion of the interior cavity and a rear portion of the interior cavity. At least one of the side walls of each of the enclosure modules includes a removable side panel, the side panel including first and second air flow openings, wherein the first air flow opening is forward of the air containment barrier and the second air flow opening is rearward of the air containment opening.

Abstract: An electronics cabinet includes front, rear and side walls, wherein the rear wall includes first and second removable panels, the first and second removable panels being mounted to the rear wall with securing fasteners and further includes a security system for preventing removal of the first and second removable panels. The security system includes: an assembly that overlies a securing fastener of the first panel and a securing fastener of the second panel; and a locking device engaging the assembly, the locking device configured to move between locked and unlocked conditions, wherein in the locked condition the locking device prevents removal of the assembly from the first and second rear panels, and in the unlocked condition the locking device permits the removal of the assembly from the first and second rear panels.

Abstract: A method of selecting a monoclonal cell colony that secretes a product of interest providing a plurality of cell culture spaces; each cell culture space has a respective assessment surface with a first binding agent immobilized on the assessment surface. The cells are incubated in a growth medium in the cell culture spaces for replication of the cells. At least some of the cells secrete a product of interest. A second binding agent is provided in the cell culture spaces. Initially, the second binding agent is not immobilized. Each of the first and second binding agents binds to the product of interest so that secretion of the product of interest by cells in any one of the cell culture spaces leads to a complex with the first binding agent, the product of interest and the second binding agent forming at the corresponding assessment surface of the cell culture space.

Abstract: The present disclosure is directed to iterative regularized reconstruction methods. In certain embodiments, the methods incorporate locally-weighted total variation denoising to suppress artifacts induced by PSF modeling. In certain embodiments, the methods are useful for suppressing ringing artifacts while contrast recovery is maintained. In certain embodiments, the weighting scheme can be extended to noisy measures introducing a noise-independent weighting scheme. The present disclosure is also directed to a method for quantifying radioligand binding in a subject without collecting arterial blood. In certain embodiments, the methods incorporate using imaging data and electronic health records to predict one or more anchors, which are used to generate an aterial input function (AIF) for the radioligand.

Abstract: The present invention relates to Radiolabeled Compounds labeled with fluorine, bromine, iodine, carbon, or tritium isotopes and methods of use thereof for treating or preventing a psychiatric disorder in a subject, for stabilizing the mood of a subject having a mood disorder, or as imaging agents for a serotonin receptor. Compositions comprising an imaging-effective amount of a Radiolabeled Compound are also disclosed.

Abstract: A method of selecting a monoclonal cell colony that secretes a product of interest providing a plurality of cell culture spaces; each cell culture space has a respective assessment surface with a first binding agent immobilised on the assessment surface. The cells are incubated in a growth medium in the cell culture spaces for replication of the cells. At least some of the cells secrete a product of interest. A second binding agent is provided in the cell culture spaces. Initially, the second binding agent is not immobilised. Each of the first and second binding agents binds to the product of interest so that secretion of the product of interest by cells in any one of the cell culture spaces leads to a complex with the first binding agent, the product of interest and the second binding agent forming at the corresponding assessment surface of the cell culture space.

Abstract: Described herein are devices for applying conductive gels to electrodes and the gel-laminated electrodes produced thereby. The devices permit the reuse of the electrodes by easily applying fresh gels to them for each subsequent use. In a first example embodiment, all of the components of the laminating device are provided in a single housing. In a second example embodiment, the gel applying and drive components are housed within the device, and a replaceable cartridge houses the gels and the gel delivery components. Also described herein are dispensers for storing and dispensing conductive gels that can be readily applied to and removed from an electrode.

Abstract: The present invention relates to Radiolabeled Compounds labeled with fluorine, bromine, iodine, carbon, or tritium isotopes and methods of use thereof for treating or preventing a psychiatric disorder in a subject, for stabilizing the mood of a subject having a mood disorder, or as imaging agents for a serotonin receptor. Compositions comprising an imaging-effective amount of a Radiolabeled Compound are also disclosed.

Abstract: Systems and methods that include selecting a physical model and a procedural model associated with an industrial plant, projecting a cross-product of the physical model and the procedural model into a unit-operation association set using a projection matrix, the unit-operation association set associating units representing equipment in the industrial plant and operations representing processes performed in the industrial plant, and establishing internal and external adjacency sets within structures, the internal adjacency set identifying connections between inputs and outputs of individual units and operations, the external adjacency set identifying connections between outputs of some units and operation and inputs of other units and operations. These systems and methods may also include generating a hyperstructure representing the industrial plant using the association and adjacency sets.

Abstract: A design structure including universal peripheral processor architecture on an integrated circuit (IC) includes a first data bus and a second data bus communicating with first and second ternary content addressable memory (TCAM) devices configured as state machines. First and second processors are coupled to the first bus interface logic and the second bus interface logic. First and second data storage devices communicate with the first and second processors and are coupled to the first and second data buses and communicate with each other. The TCAM devices are configured as state machines and are coupled to and adapted to interface with the processors, the data storage devices, and the bus interface logic using predefined protocols.

Abstract: The present invention relates to Radiolabeled Compounds and methods of use thereof for treating or preventing a psychiatric disorder in a subject, for stabilizing the mood of a subject having a mood disorder, or as imaging agents for a serotonin receptor. Compositions comprising an imaging-effective amount of a Radiolabeled Compound are also disclosed.

Abstract: Systems and methods that include selecting a physical model and a procedural model associated with an industrial plant, projecting a cross-product of the physical model and the procedural model into a unit-operation association set using a projection matrix, the unit-operation association set associating units representing equipment in the industrial plant and operations representing processes performed in the industrial plant, and establishing internal and external adjacency sets within structures, the internal adjacency set identifying connections between inputs and outputs of individual units and operations, the external adjacency set identifying connections between outputs of some units and operation and inputs of other units and operations. These systems and methods may also include generating a hyperstructure representing the industrial plant using the association and adjacency sets.

Abstract: Described herein are devices for applying conductive gels to electrodes and the gel-laminated electrodes produced thereby. The devices permit the reuse of the electrodes by easily applying fresh gels to them for each subsequent use. In a first example embodiment, all of the components of the laminating device are provided in a single housing. In a second example embodiment, the gel applying and drive components are housed within the device, and a replaceable cartridge houses the gels and the gel delivery components. Also described herein are dispensers for storing and dispensing conductive gels that can be readily applied to and removed from an electrode.

Abstract: A design structure including universal peripheral processor architecture on an integrated circuit (IC) includes a first data bus and a second data bus communicating with first and second ternary content addressable memory (TCAM) devices configured as state machines. First and second processors are coupled to the first bus interface logic and the second bus interface logic. First and second data storage devices communicate with the first and second processors and are coupled to the first and second data buses and communicate with each other. The TCAM devices are configured as state machines and are coupled to and adapted to interface with the processors, the data storage devices, and the bus interface logic using predefined protocols.

Abstract: A universal peripheral processor architecture on an integrated circuit (IC) includes a first data bus and a second data bus communicating with first and second ternary content addressable memory (TCAM) devices configured as state machines. First and second processors are coupled to the first bus interface logic and the second bus interface logic. First and second data storage devices communicate with the first and second processors and are coupled to the first and second data buses and communicate with each other. The TCAM devices are configured as state machines and are coupled to and adapted to interface with the processors, the data storage devices, and the bus interface logic using predefined protocols.

Abstract: The present invention relates to Radiolabeled Arylsulfonyl Compounds and methods of use thereof as imaging agents for the COX-2 enzyme using positronemission tomograpy (PET). Methods of making the Radiolabeled Arylsulfonyl Compounds and pharmaceutical compositions comprising an effective amount of a Radiolabeled Arylsulfonyl Compound are also disclosed.

Abstract: The present invention relates to Radiolabeled Compounds and methods of use thereof for treating or preventing a psychiatric disorder in a subject, for stabilizing the mood of a subject having a mood disorder, or as imaging agents for a serotonin receptor. Compositions comprising an imaging-effective amount of a Radiolabeled Compound are also disclosed.

Abstract: A drug conjugate comprising a targeting agent and an anti-cancer agent, wherein said targeting agent comprises an erythropoietin receptor ligand, is described. The drug conjugate can be used in methods of treating cancer. Also described are methods of treating cancer using the conjugate, methods of diagnosis, methods of imaging and pharmaceutical compositions.

Abstract: The present invention provides a method and system of extracting information about references to entities from a plurality of electronic documents. In an exemplary embodiment, the method and system include (1) applying at least one document quality measure to each of the plurality of electronic documents, (2) recognizing the references to entities in the plurality of electronic documents, (3) using at least one reference quality measure for each of the references to entities, (4) computing at least one topical category associated with each of the references to entities, (5) finding at least one co-occurring term associated with each of the references to entities, and (6) characterizing each of the references to entities by at least one characteristic category.

Abstract: A drug conjugate comprising a targeting agent and an anti-cancer agent, wherein said targeting agent comprises an erythropoietin receptor ligand, is described. The drug conjugate can be used in methods of treating cancer. Also described are methods of treating cancer using the conjugate, methods of diagnosis, methods of imaging and pharmaceutical compositions.