Abstract: The method of maintaining a first flow rate through a first valve in a fluid delivery system, the fluid delivery system including a and a plurality of fluid valves in fluid communication with the pump, and a controller controlling the pressure generated by the pump and the position of the plurality of valves. The method includes providing the first flow rate of a fluid pressurized by the pump through the first valve, receiving a request for a second flow rate of the fluid through a second valve, determining a predicted effect on the first flow rate based on the request, adjusting at least one of the position of the first valve and the pressure generated by the pump to maintain the first flow rate based on the predicted effect, and adjusting the position of the second valve to provide the second flow rate of the fluid through the second valve.

Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: A processor arranged to compress neural network activation data comprising an input module for obtaining neural network activation data. The processor also comprises a block creation module arranged to split the neural network activation data into a plurality of blocks; and a metadata generation module for generating metadata associated with at least one of the plurality of blocks. Based on the metadata generated a selection module selects a compression scheme for each of the plurality of blocks, and a compression module for applying the selected compression scheme to the corresponding block to produce compressed neural network activation data. An output module is also provided for outputting the compressed neural network activation data.

Abstract: The present disclosure provides T cell modulatory polypeptides (T-Cell-MPs) comprising a chemical conjugation site at which a KRAS epitope has been conjugated and at least one immunomodulatory polypeptide sequence that may be selected to exhibit reduced binding affinity to its cognate co-immunomodulatory polypeptide. The T-Cell-epitope conjugates are useful for modulating (e.g., increasing proliferation or cytotoxic activity) the activity of T cells specific to the conjugate epitope, and accordingly for use as therapeutics. The T-Cell-epitope conjugates find use in treating a variety of cancers associated with KRAS.

Abstract: The present invention relates to inkjet ink compositions that take advantage of solvent mixtures containing an ester, a ketone, and optionally an alcohol, in order to provide ink compositions that have suitable qualities for inkjet printing. Preferred ink compositions include a C1-C3 alkyl ester of C1-C3 carboxylic acid, a C3-C7 ketone, and optionally a C2-C3 alkyl alcohol.

Abstract: This invention relates to a valve assembly comprising (a) a valve body defining a valve chamber, an inlet port and a discharge port, wherein the inlet port and discharge port communicate with the valve chamber; and (b) a valve member in the valve chamber, the valve member comprising a passage having (1) a first opening and (2) a second opening housing a filter having an inlet surface proximate to the inlet port and a discharge surface proximate to the discharge port, wherein the passage communicates with the inlet port and discharge port, and wherein the valve member is moveable to alternately juxtapose the inlet port and either the filter inlet surface or the filter discharge surface. The invention further relates to a particulate material metering and/or feed system comprising the valve assembly.

Abstract: A novel steerable solid axle suspension system capable of eliminating the need for steering dampers includes a solid axle (12) suspended from a vehicle frame (14) by leaf spring assemblies (48) and right and left shock absorbers (30, 38). The suspension also includes a track bar (140) laterally connecting the solid axle (12) to the frame (14). The suspension also includes a steering gear (132) having a pitman arm (130) connected to a drag link (128). The drag link (128) extends downwardly to connect to a tie rod (122) which extends between and interconnects first and second steering knuckles (24, 22).

Abstract: A novel twin I-beam front suspension system is disclosed having a first and a second radius arm, the rearward end of each radius arm being adapted to cooperate with a bushing to connect to the vehicle frame. The radius arm bushing static rate on one side of the suspension differs from the radius arm bushing static rate on the other side of the suspension so as to balance the radius arm longitudinal deflections on the two sides of the vehicle. In the preferred embodiment, a silent block bushing replaces the traditional radius arm bushing to reduce pan complexity and to provide increased radius arm bushing life. Radius arm systems are also disclosed which permit quick, easy and accurate adjustment of the front wheel caster angle. A parallelogram steering linkage decouples the two front wheels from one another to provide a toe curve for each front tire that is independent of the vertical displacement of the other front tire.

Abstract: A sulfate scavenger for chromium-plating baths consists of barium chromate or dichromate or mixtures of the two, added either directly to the bath or as part of a replenishment mixture with chromic acid.