Patents by Inventor John Michael Daly

John Michael Daly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRANSGENIC NON-HUMAN ANIMALS FOR PHARMACOLOGICAL AND TOXICOLOGICAL STUDIES
    Publication number: 20100319076
    Abstract: The present invention is directed to the production, breeding and use of transgenic non-human animals such as mice in which specific genes or portions of genes have been replaced by homologues from another animal to make the physiology of the animals so modified more like that of the other animal with respect to drug pharmacokinetics and metabolism. The invention also extends to the use of the genetically modified non-human animals of the invention for pharmacological and/or toxicological studies.
    Type: Application
    Filed: August 20, 2010
    Publication date: December 16, 2010
    Applicant: GENE STREAM PTY LIMITED
    Inventor: John Michael Daly
  • Transgenic non-human animals for pharmacological and toxicological studies
    Patent number: 7781643
    Abstract: The present invention is directed to the production, breeding and use of transgenic non-human animals such as mice in which specific genes or portions of genes have been replaced by homologues from another animal to make the physiology of the animals so modified more like that of the other animal with respect to drug pharmacokinetics and metabolism. The invention also extends to the use of the genetically modified non-human animals of the invention for pharmacological and/or toxicological studies.
    Type: Grant
    Filed: April 13, 2009
    Date of Patent: August 24, 2010
    Assignee: Gene Stream Pty Limited
    Inventor: John Michael Daly
  • BIOLUMINESCENT ASSAYS UTILISING SECRETED LUCIFERASES
    Publication number: 20100092967
    Abstract: Disclosed herein are methods for determining the amount or activity of one or more luciferases and methods for measuring the luminescent signal generated by one or more luciferases in a sample, the methods comprising incubating the sample with a reactive substrate(s) of the luciferase(s) to be analysed and a reducing agent to inactivate a first luciferase, wherein the first luciferase, in its native form, is a secreted luciferase.
    Type: Application
    Filed: December 21, 2007
    Publication date: April 15, 2010
    Applicant: GENE STREAM PTY LTD
    Inventors: Marco Peter Leu, John Michael Daly
  • LUCIFERASE SIGNAL ENHANCING COMPOSITIONS
    Publication number: 20100055693
    Abstract: Reagents and compositions for use in reactions catalysed by luciferase enzymes, and in particular for use in luciferase-based gene reporter assays are described. The invention also provides methods and compositions for, inter alia, increasing the sensitivity and/or improving the kinetics of luciferase-catalysed reactions.
    Type: Application
    Filed: October 24, 2007
    Publication date: March 4, 2010
    Applicant: GENE STREAM PTY LTD.
    Inventors: Marco Peter Leu, John Michael Daly
  • TRANSGENIC NON-HUMAN ANIMALS FOR PHARMACOLOGICAL AND TOXICOLOGICAL STUDIES
    Publication number: 20090241204
    Abstract: The present invention is directed to the production, breeding and use of transgenic non-human animals such as mice in which specific genes or portions of genes have been replaced by homologues from another animal to make the physiology of the animals so modified more like that of the other animal with respect to drug pharmacokinetics and metabolism. The invention also extends to the use of the genetically modified non-human animals of the invention for pharmacological and/or toxicological studies.
    Type: Application
    Filed: April 13, 2009
    Publication date: September 24, 2009
    Applicant: GENE STREAM PTY LIMITED
    Inventor: JOHN MICHAEL DALY
  • Transgenic non-human animals for pharmacological and toxicological studies
    Patent number: 7544854
    Abstract: The present invention is directed to the production, breeding and use of transgenic non-human animals such as mice in which specific genes or portions of genes have been replaced by homologues from another animal to make the physiology of the animals so modified more like that of the other animal with respect to drug pharmacokinetics and metabolism. The invention also extends to the use of the genetically modified non-human animals of the invention for pharmacological and/or toxicological studies.
    Type: Grant
    Filed: April 18, 2002
    Date of Patent: June 9, 2009
    Assignee: Gene Stream Pty Limited
    Inventor: John Michael Daly