Abstract: A door lock can include a latch housing and a movable hasp. The latch housing can be configured to be secured with a door. The movable hasp can engage a catch secured to a door frame. The latch is movable relative to latch housing between an engaged position blocking against movement of the door and a disengaged position allowing movement of the door. Penetration through the door can be aligned with a sensor of the door lock to permit monitoring.

Abstract: Provided herein, inter alia, are compositions and methods for treating and/or preventing conditions associated with gut inflammation caused by dysbiosis via use of exogenously administered acid phosphatases or enzymes of the GDA1_CD39 superfamily (such as apyrases).

Abstract: Glass and glass ceramic compositions having at least a lithium disilicate crystalline phase, a petalite crystalline phase, and a residual glass phase along with methods of making the glass and glass ceramic compositions are described. The compositions are compatible with conventional rolling and float processes, are transparent or translucent, and have high mechanical strength and fracture resistance. Additionally, processes of 3D forming glass ceramic preforms having the glass ceramic composition discussed to produce glass ceramic articles are described. Further, the compositions are able to be chemically tempered to even higher strength glass ceramics that are useful as large substrates in multiple applications.

Abstract: An ophthalmic instrument includes a blade laterally symmetric about a longitudinal axis with a first triangular portion having first opposed cutting edges and a first longitudinal length extending from an anterior tip to a first position, the first position having a first width, a second portion having parallel second edges and a second longitudinal length extending from the first position to a second position, and a third portion having third opposed cutting edges and a third longitudinal length extending from the second position to a third position, the third position having a third width that is greater than the first width.

Abstract: In immunoglobulin light chain amyloidosis (AL), the unique antibody light chain (LC) protein that is secreted by monoclonal plasma cells in each patient misfolds and/or aggregates, a process leading to organ degeneration. For treating AL patients, such as those with substantial cardiac involvement who have difficulty tolerating existing chemotherapy regimens, provided herein are small molecule compounds of Formula Ia, Formula Ib, and Formula II that are kinetic stabilizers of the native dimeric structure of full-length LCs, which compounds can slow or stop the amyloidogenicity cascade at its origin.

Abstract: Techniques for performing floating-point to integer conversion with saturation are described. In some examples, an instruction is executed to perform the conversion. In some examples, a single instruction to include at least one or more fields for an opcode and one or more fields for location information for at least a first source operand and a destination operand, wherein the opcode is to indicate execution circuitry is to convert, using truncation or saturation, each floating-point data element of at least the first source operand to an integer value and store the integer value into a corresponding data element position of the destination operand, wherein truncation is to be used when a conversion is inexact and saturation is to be used when a conversion overflows.

Abstract: Detailed herein are examples of instructions and their hardware support for floating-point comparison that makes use of the distinction between signed integer comparison and unsigned integer comparison to make an analogous distinction between floating-point relationships including unordered and those that do not. These instructions may reduce the number of instructions required to compare and conditionally execute operations in a program, including instructions to load values and instructions to explicitly test for the unordered condition.

Abstract: A digital/virtual gift product is provided for generation and customization by a giver through a service provider and for receipt by a recipient for use with a merchant. The digital/virtual gift product includes: a representation of a monetary gift value selected by the giver and depicted on the digital/virtual gift product for use and redemption with a preselected merchant; a merchant identification depicted on the digital/virtual gift product to identify the preselected merchant, selected by the giver, and at which preselected merchant the digital/virtual gift product is redeemable; and a giver identification to identify the giver of the digital/virtual gift product to the recipient and to the merchant. At least one system and associated methods also are disclosed for creating, customizing, and tracking multiple digital/virtual gift products.

Abstract: A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.

Abstract: Systems, methods, and software described herein provide improvements of identifying stances of data sources for events. In one implementation, an event summary service identifies data objects that correspond to an event and identifies a data source from a plurality of data sources for each of the data objects. The summary service further, for each data object of the data objects, processing the data object to identify pertinent data related to a stance for the data source for the data object in relation to the event, and identifies a stance for each of the plurality of data sources based on the pertinent data identified in the data objects.

Abstract: A hub is disclosed that includes a network, first and second modules, a processor, a failsafe bus, and an alarm wire bus. The network interface component communicates data with a medical device. The first module interfaces with a first communications channel, and the second module interfaces with a second communications channel. The processor packages the data from the medical device into at least one packet. The processor communicates with one of the first and second modules to communicate one or more packets over one of the first and second communications channels. The failsafe bus signals from the hub to the medical device when a fatal-error fault condition of the hub has occurred. The alarm wire bus signals from the hub to the medical device when an alarm condition of the hub has occurred to cause the medical device to execute at least one mitigation.

Abstract: A customer access system includes one or more customer access portals to dispense ordered items to customers and/or receive returned items from customers. A tote transfer system transports one or more totes to carry the ordered items and the returned items to and from the customer access portals. The customer access system may also include a storage structure to temporarily store one or more totes to provide a buffer to reduce or mitigate customer wait times at the customer access portal and/or to more efficiently disposition items by consolidating returned items. The storage structure may further allow “asynchronous dispositioning” of returned items where the retrieval of a returned item from the customer and the dispositioning of the returned item occurs at different times. In some implementations, the customer access portal includes one or more drawers to exchange of items with a customer in a safe and efficient manner.

Abstract: Devices and methods are disclosed for improved followability in laser-based ocular procedures. In some embodiments, an ophthalmic instrument comprises a projection located at the distal end of the shaft or cannula, the projection having a distal surface in proximity to the distal end of the optical fiber, the distal surface adapted to be positioned facing the treatment area during use of the ophthalmic instrument. An example method includes delivering laser energy through an optical fiber to the treatment area, wherein the distal surface of the projection inhibits bubbles formed during the procedure from moving distally away from the distal end of the ophthalmic instrument.

Abstract: Apparatus and methods for page-based soft post package repair are disclosed. Based on data stored in a storage element, an address may be decoded to a prime row, a row-based redundant row, or a page-based redundant row. A match logic circuit may determine whether the address corresponds to a defective prime row and generate a match signal. A decoder can select a redundant row to be accessed instead of a prime row in response to the match signal indicating that the address data corresponding to the address to be accessed matches defective address data stored in a volatile memory. A page-based redundant row allows for page-by-page substitution for defective memory, allowing functional portions of memory to continue to be used.

Abstract: The invention relates to compounds of formula (I): or a salt thereof, wherein R1, R5, R7, R8, X, m, n, p and q are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are ?v?6 integrin inhibitors that are useful for treating tissue specific fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSW).

Abstract: Compositions for prevention of Foot and Mouth Disease (FMD) are provided, comprising an antigen component in the amount equivalent to 0.5-20 ?g FMD virus and an adjuvant component comprising oil, an immunostimulatory oligonucleotide, and a polycationic carrier. Methods of using the composition, as well as the methods of reducing FMD persistence are also provided.

Abstract: Systems and methods are provided to process a digital photo and other media. An apparatus to process digital photos can include a tangibly embodied computer processor (CP) and a tangibly embodied database. The CP can perform processing including: (a) inputting a photo from a user device, and the photo including geographic data that represents a photo location at which the photo was generated; (b) comparing at least one area with the photo location and associating an area identifier to the photo as part of photo data; and (c) performing processing based on the area identifier and the photo data.

Abstract: The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals.

Abstract: Disclosed are a series of compounds or their tautomers having a general structure represented by Formula Ia, Ib, IIa, IIb, or IIc and pharmaceutically acceptable salts thereof. The present disclosure also relates to pharmaceutical compositions comprising said compounds or tautomers. The present disclosure further relates to a method of treating a disease or condition associated with iron dysregulation or dysfunctional iron homeostasis comprising administering to a subject in need thereof a therapeutically effective amount of Formula Ia, Ib, IIa, IIb, or IIc compounds or tautomers.