Abstract: The present invention is directed to antibodies and antigen binding fragments thereof having binding specificity for PACAP. The antibodies and antigen binding fragments thereof comprise the sequences of the VH, VL, and CDR polypeptides described herein, and the polynucleotides encoding them. Antibodies and antigen binding fragments described herein bind to and/or compete for binding to the same linear or conformational epitope(s) on human PACAP as an anti-PACAP antibody. The invention contemplates conjugates of anti-PACAP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. Methods of making said anti-PACAP antibodies and antigen binding fragments thereof are also contemplated.

Abstract: A system includes a synthesizer unit having a fluid input to receive fluids and a communication input to receive commands to synthesize data-encoded DNA sequences and cleave the DNA. A first flexible chemistry reaction chamber module may be fluidically coupled to the synthesizer unit to receive the data-encoded DNA sequences and amplify the sequences. A deposition unit may be fluidically coupled to the first flexible chemistry reaction chamber module to receive the amplified DNA sequences and encapsulate the amplified DNA sequences into one or more wells in a storage plate for storage and retrieval to and from a plate storage unit. Retrieved DNA may be processed and read by further units.

Abstract: A system includes a synthesizer unit having a fluid input to receive fluids and a communication input to receive commands to synthesize data-encoded DNA sequences and cleave the DNA. A first flexible chemistry reaction chamber module may be fluidically coupled to the synthesizer unit to receive the data-encoded DNA sequences and amplify the sequences. A deposition unit may be fluidically coupled to the first flexible chemistry reaction chamber module to receive the amplified DNA sequences and encapsulate the amplified DNA sequences into one or more wells in a storage plate for storage and retrieval to and from a plate storage unit. Retrieved DNA may be processed and read by further units.

Abstract: A system for indirect border gateway routing comprising a provider edge router; at least one virtual routing and forwarding instance in communication with the provider edge router, each virtual routing and forwarding instance including a route target; a pointer identification list in communication with the provider edge router, the pointer identification list containing at least one route target associated with a virtual routing and forwarding instance; and a virtual routing and forwarding import instance adapted to receive a route from the provider edge router, the route including a pointer identification directing the virtual routing and forwarding import instance to scan the pointer identification list for the route target associated with the plural virtual routing and forwarding instance, and wherein the virtual routing and forwarding import instance is further adapted to import the route to the at least one virtual routing and forwarding instance having a route target on the pointer identification list.

Abstract: A system includes a synthesizer unit having a fluid input to receive fluids and a communication input to receive commands to synthesize data-encoded DNA sequences and cleave the DNA. A first flexible chemistry reaction chamber module may be fluidically coupled to the synthesizer unit to receive the data-encoded DNA sequences and amplify the sequences. A deposition unit may be fluidically coupled to the first flexible chemistry reaction chamber module to receive the amplified DNA sequences and encapsulate the amplified DNA sequences into one or more wells in a storage plate for storage and retrieval to and from a plate storage unit. Retrieved DNA may be processed and read by further units.

Abstract: A system for indirect border gateway routing comprising a provider edge router; at least one virtual routing and forwarding instance in communication with the provider edge router, each virtual routing and forwarding instance including a route target; a pointer identification list in communication with the provider edge router, the pointer identification list containing at least one route target associated with a virtual routing and forwarding instance; and a virtual routing and forwarding import instance adapted to receive a route from the provider edge router, the route including a pointer identification directing the virtual routing and forwarding import instance to scan the pointer identification list for the route target associated with the plural virtual routing and forwarding instance, and wherein the virtual routing and forwarding import instance is further adapted to import the route to the at least one virtual routing and forwarding instance having a route target on the pointer identification list.

Abstract: Systems and methods are described that manage routing information in an IP network using extensible indexing and use the indexing to control the network. The indexing and associated controls apply to any router within the routing domain.

Abstract: A system and method of dynamically managing a power supply allocation for each one of the server blades in a blade server includes a blade server system having a blade chassis, multiple server blades coupled to the blade chassis, a power supply system coupled to the blade chassis, a chassis management module coupled to the blade chassis, wherein the blade chassis includes electrical and data communication interconnections between the server blades, the redundant power supply system and the chassis management module. The chassis management module includes computer readable media having program instructions for dynamically managing a power supply allocation for each one of the server blades.

Abstract: Embodiments of the present invention include processing steps and subsystems, within automated-biopolymer-synthesis systems and within other automated systems for organic-chemistry-based processing, for removing reagent solutions and solvents from reaction chambers following various synthetic reaction steps and washing steps undertaken during biopolymer synthesis. Embodiments of the present invention employ any of various different types of liquid-absorbing materials to wick, or remove by capillary action, liquids from reaction chambers. Wicking-based methods and subcomponents of the present invention remove significantly greater fractions of solutions from reaction chambers than conventional methods and subsystems and, in addition, are mechanically simpler and produce fewer deleterious side effects than currently used methods and subsystems.

Abstract: A system and method of dynamically managing a power supply allocation for each one of the server blades in a blade server includes a blade server system having a blade chassis, multiple server blades coupled to the blade chassis, a power supply system coupled to the blade chassis, a chassis management module coupled to the blade chassis, wherein the blade chassis includes electrical and data communication interconnections between the server blades, the redundant power supply system and the chassis management module. The chassis management module includes computer readable media having program instructions for dynamically managing a power supply allocation for each one of the server blades.

Abstract: In a first aspect a fire fighting foaming composition contains a partially acetylated polyvinyl alcohol. In a second aspect the fire fighting foaming composition contains chitosan together with a surfactant such as a protein derived surfactant or a hydrocarbon surfactant which is either amphoteric or non-ionic. The compositions can form effective fire fighting foams in the absence of fluorinated surfactants and other fluorinated compounds.

Abstract: Embodiments of the present invention are directed to automated-polymer-synthesis systems that include discrete reagent-solution-addition, wait-time, and reagent-solution-draining sub-systems which together significantly increase throughput and decrease sub-system idle time. The automated-polymer-synthesis systems that represent embodiments of the present invention additionally include switches at points in which carriers can be received from multiple input paths or output to multiple different output paths. The automated-polymer-synthesis systems that represent embodiments of the present invention generally include an input spur and output spur in addition to a main loop, allowing carriers containing only completed polymers to be removed and new carriers input, so that carriers traverse the automated-polymer-synthesis systems independently from one another.

Abstract: Systems and methods are described that manage routing information in an IP network using extensible indexing and use the indexing to control the network. The indexing and associated controls apply to any router within the routing domain.

Abstract: An endless track support roller is mounted for rotation about a shaft adapted for being fixed between parallel rails of a track support frame. The roller comprises mirror image halves, with a pair of thrust bushings being received on the shaft and respectively disposed in supporting relationship to the roller halves. Each thrust bushing includes an axially outwardly facing thrust face. Mounting brackets fixed to opposite ends of the shaft are adapted to be fixed to the pair of frame rails. Non-uniform edge loading of the bushings resulting from shaft deformations caused by flexure of the frame rails is minimized by providing axially inwardly facing ends of the brackets with spherically contoured surfaces, and by locating an annular spacer between each bracket and bushing thrust face, the annular spacer having outer and inner axially facing surfaces respectively shaped complimentary to the spherically contoured bracket surface and to the bushing thrust face.

Abstract: Embodiments of the present invention are directed to automated-polymer-synthesis systems that include discrete reagent-solution-addition, wait-time, and reagent-solution-draining sub-systems which together significantly increase throughput and decrease sub-system idle time. The automated-polymer-synthesis systems that represent embodiments of the present invention additionally include switches at points in which carriers can be received from multiple input paths or output to multiple different output paths. The automated-polymer-synthesis systems that represent embodiments of the present invention generally include an input spur and output spur in addition to a main loop, allowing carriers containing only completed polymers to be removed and new carriers input, so that carriers traverse the automated-polymer-synthesis systems independently from one another.

Abstract: Embodiments of the present invention include processing steps and subsystems, within automated-biopolymer-synthesis systems and within other automated systems for organic-chemistry-based processing, for removing reagent solutions and solvents from reaction chambers following various synthetic reaction steps and washing steps undertaken during biopolymer synthesis. Embodiments of the present invention employ any of various different types of liquid-absorbing materials to wick, or remove by capillary action, liquids from reaction chambers. Wicking-based methods and subcomponents of the present invention remove significantly greater fractions of solutions from reaction chambers than conventional methods and subsystems and, in addition, are mechanically simpler and produce fewer deleterious side effects than currently used methods and subsystems.

Abstract: Systems and methods are described that manage routing information in an IP network using extensible indexing and use the indexing to control the network. The indexing and associated controls apply to any router within the routing domain.

Abstract: A roller for supporting an endless track of a track laying tractor is mounted for rotation about a shaft or axle fixed between transversely spaced, parallel rails of a track support frame. The roller is constructed of mirror image halves having axially inner ends welded together, with a pair of thrust bushings being received on the shaft and respectively disposed in supporting relationship the roller halves. Each thrust bushing includes an axially outer end defined by an annular flange having an axially outwardly facing flat bearing surface. A pair of mounting brackets are respectively received on, and fixed to opposite ends of the shaft and fixed to the pair of rails of the support frame.

Abstract: Systems and methods are described that manage routing information in an IP network using extensible indexing and use the indexing to control the network. The indexing and associated controls apply to any router within the routing domain.

Abstract: In a first aspect a fire fighting foaming composition contains a partially acetylated polyvinyl alcohol. In a second aspect the fire fighting foaming composition contains chitosan together with a surfactant such as a protein derived surfactant or a hydrocarbon surfactant which is either amphoteric or non-ionic. The compositions can form effective fire fighting foams in the absence of fluorinated surfactants and other fluorinated compounds.