Abstract: The present invention relates to aggregate particles comprising nanoparticulate drug particles. In particular, the present invention is directed to aggregate particles comprising nanoparticulate drug particles of umeclidinium bromide and optionally vilanterol trifenatate and/or fluticasone furoate. Aggregate particles of the present invention may further comprise nanoparticulate excipient particles and one or more binders. The invention also relates to powder compositions suitable for inhalation that comprise said aggregate particles, processes of producing said aggregate particles, and use of said powder compositions in the treatment of respiratory diseases, such as asthma and COPD.

Abstract: A method of making aggregate particles suitable for a powder aerosol composition that includes forming a dispersion of nanoparticulate drug and/or excipient in a non-aqueous liquid, and spray-drying the dispersion to generate aggregate particles having a mass median aerodynamic diameter of less than or equal to about 100 microns, and particles generated by such method, and compositions of said particles.

Abstract: The present invention relates to aggregate particles comprising nanoparticulate drug particles. In particular, the present invention is directed to aggregate particles comprising nanoparticulate drug particles of umeclidinium bromide and optionally vilanterol trifenatate and/or fluticasone furoate. Aggregate particles of the present invention may further comprise nanoparticulate excipient particles and one or more binders. The invention also relates to powder compositions suitable for inhalation that comprise said aggregate particles, processes of producing said aggregate particles, and use of said powder compositions in the treatment of respiratory diseases, such as asthma and COPD.

Abstract: An aerosol generator includes a housing, a heater and a mouthpiece wherein the heater volatilizes liquid material within a flow passage and forms an aerosol in the mouthpiece. Mixing ambient air with the vaporized liquid material controls a droplet size of the aerosol. The ambient air can be directed into the mouthpiece by at least one air passageway in an airflow entrainment control member. The at least one air passageway provides a desired volume and/or velocity of ambient air entering into the mouthpiece thereby achieving a desired droplet size distribution of an aerosol. In an alternative arrangement, a funnel shaped airflow entrainment control member includes a narrow end proximate the outlet end of the flow passage. A cone angle of the funnel-shaped member can be selected to provide a desired volume of ambient air which mixes with the vaporized liquid material and achieves a desired aerosol droplet size distribution.

Abstract: An aerosol generator includes a housing, a heater and a mouthpiece wherein the heater volatilizes liquid material within a flow passage and forms an aerosol in the mouthpiece. Mixing ambient air with the vaporized liquid material controls a droplet size of the aerosol. The ambient air can be directed into the mouthpiece by at least one air passageway in an airflow entrainment control member. The at least one air passageway provides a desired volume and/or velocity of ambient air entering into the mouthpiece thereby achieving a desired droplet size distribution of an aerosol. In an alternative arrangement, a funnel shaped airflow entrainment control member includes a narrow end proximate the outlet end of the flow passage. A cone angle of the funnel-shaped member can be selected to provide a desired volume of ambient air which mixes with the vaporized liquid material and achieves a desired aerosol droplet size distribution.