Abstract: Provided herein are compounds that act as molecular glues, inducing degradation of CK1? or CK1?/GSPT1, and pharmaceutically acceptable derivatives thereof. Also provided are pharmaceutical compositions containing the compounds and methods of using the compounds for treating a subject with a proliferative disease.

Abstract: The present invention describes a novel outdoor enclosure for circulating pumps for outdoor tankless heaters, outdoor boilers and other outdoor applications. The enclosure includes a body and a cover with the body attaching to the circulator motor. When closed, the enclosure keeps rainfall and other contaminates from entering the wiring space within the enclosure and the circulator motor. The body of the enclosure has multiple ports for electrical wiring inputs for power and for controls connections which can be made with flexible cords and/or hardwires. The outdoor enclosure can be equipped with a terminal strip to simplify wiring and/or with a timer to control when the circulator operates. To avoid problems associated with freezing, the enclosure may include a thermal device that turns the circulator on if temperatures drop. To secure the cover to the body, fastener tabs are included that can accept a screw or lock.