Abstract: A continuous automated perfusion culture analysis system (CAPCAS) comprises one or more fluidic systems configured to operate large numbers of biodevices in parallel. Each fluidic system comprises an input reservoir plate for receiving media; a biodevice plate comprising an array of biodevices fluidically coupled to the input reservoir plate, configured such that each biodevice has independent media delivery, fluid removal, stirring, and gas control, and each biodevice is capable of continuously receiving the media from the input reservoir plate; and an output plate fluidically coupled to the biodevice plate for real-time analysis and sampling. The operations of the CAPCAS are automated and computer-controlled wirelessly. The CAPCAS can also be used for abiotic and biotic chemical synthesis processes.

Abstract: The present disclosure provides recombinant adeno-associated virus (AAV) virions with altered capsid protein, where the recombinant AAV (rAAV) virions exhibit greater ability to cross barriers between intravitreal fluid and retinal cells, and thus greater infectivity of a retinal cell compared to wild-type AAV, and where the rAAV virions comprise a heterologous nucleic acid. The present disclosure provides methods of delivering a gene product to a retinal cell in an individual.

Abstract: An apparatus is described that is operable between a raised and lowered position for lifting an object without pivot or rotational joints. The apparatus may include an arrow rest for use with an archery bow, wherein the arrow rest has arrow support members operable to form a v-shaped arrow supporting notch, wherein the support members slide in a non-pivotal, non-rotational manner to vary a depth of the v-shaped notch. The support members are oriented to slide between a raised and lowered position. The arrow rest is suitable for coupling to the bow in a manner so that as the bow string is drawn the support members raise the arrow into a shooting position, and when the bow string is released the support members slide away from the arrow to avoid contact between the arrow and support members. Further, the arrow rest is adjustable to accommodate various diameter arrow shafts and to adjust the lateral and vertical orientation of the arrow shaft relative to the riser.

Abstract: A compound archery bow has power cable adjusters operable to laterally adjust the power cable to minimize canting of the cam assemblies and adjust the effective length of the power cable to vary the timing of the cam assembly connected to the power cable. Limb pocket assemblies connect the flexible limbs to a riser with a compression clamping force. Opposing side plates are held in compression relation with the limb end with bolts turned down tight into a base supporting the limb end. The compression connection between the limb pocket assembly maintains the limb in a center line alignment with the vertical plane of the bow string and riser.

Abstract: A compound archery bow has an overdraw apparatus allowing use of shorter and lighter arrows. The overdraw apparatus has a rearwardly extended bar secured to the midsection of the bow. A cable guard rod is adjustably mounted on the top portion of the bar for laterally locating cable strands relative to the bow cable. An arrow rest adjustably mounted on the bar has a pair of arrow supporting fingers for supporting an arrow in alignment with the bow string.