Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A device and system for purifying a fluid is provided. The system includes a tank having an interior space and a media container disposed within the interior space. A valve is provided that cooperates with an element within the interior, the valve being movable between an open and a closed position. The valve being biased to the open position when the element is not positioned within the interior space, wherein the interior space is fluidly coupled to the atmosphere in the open position. The valve further being configured to move to a closed position when the element is positioned within the interior space.

Abstract: A neuromodulation therapy is delivered via at least one electrode implanted subcutaneously and superficially to a fascia layer superficial to a nerve of a patient. In one example, an implantable medical device is deployed along a superficial surface of a deep fascia tissue layer superficial to a nerve of a patient. Electrical stimulation energy is delivered to the nerve through the deep fascia tissue layer via implantable medical device electrodes.

Abstract: A neuromodulation therapy is delivered via at least one electrode implanted subcutaneously and superficially to a fascia layer superficial to a nerve of a patient. In one example, an implantable medical device is deployed along a superficial surface of a deep fascia tissue layer superficial to a nerve of a patient. Electrical stimulation energy is delivered to the nerve through the deep fascia tissue layer via implantable medical device electrodes.

Abstract: A superconductor device includes a high superconductivity transition temperature enhanced from the raw material transition temperature. The superconductor device includes a matrix material and a core material. The enhancing matrix material and the core material together create a system of strongly coupled carriers. A plurality of low-dimensional conductive features can be embedded in the matrix. The low-dimensional conductive features (e.g., nanowires or nanoparticles) can be conductors or superconductors. An interaction between electrons of the low-dimensional conductive features and the enhancing matrix material can promote excitations that increase a superconductivity transition temperature of the superconductor device.

Abstract: Devices, systems and methods for controlling a patient's body temperature by endovascular heat exchange.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: This invention relates to the preparation of N-(phosphonomethyl)glycine (“glyphosate”) from N-(phosphonomethyl)iminodiacetic acid (“PMIDA”), and more particularly to methods for control of the conversion of PMIDA, for the identification of reaction end points relating to PMIDA conversion and the preparation of glyphosate products having controlled PMIDA content.

Abstract: Methods of prevention of symptomatic malaria in a malaria-naïve, G6PD-normal human subject comprising administering to the human subject a compound of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I): A compound of Formula (I) can be administered prior to potential exposure of a species of Plasmodium, during potential exposure of a species of Plasmodium, and after potential exposure of a species of Plasmodium. The methods of the invention also pertains to kits comprising specific doses of Formula (I), a pharmaceutically acceptable salt thereof, or pharmaceutical composition comprising a compound of Formula (I), and instructions for administration of dosing quantity and frequency. The methods of the invention also pertain to determining doses of Formula (I) that meet the general regulatory requirement for a drug to be efficacious in the prevention of malaria in malaria-naïve subjects.

Abstract: A device and system for purifying a fluid is provided. The system includes a tank having an interior space and a media container disposed within the interior space. A valve is provided that cooperates with an element within the interior, the valve being movable between an open and a closed position. The valve being biased to the open position when the element is not positioned within the interior space, wherein the interior space is fluidly coupled to the atmosphere in the open position. The valve further being configured to move to a closed position when the element is positioned within the interior space.

Abstract: A sensor assembly includes a sensor unit including a generally rigid sensor housing and at least one electronic sensor component, a conduit coupled with the sensor unit and extending away from the sensor housing, and a rigid support structure supporting a portion of at least one of the conduit or the sensor housing at a first end adjacent the sensor unit and extending away from the sensor unit to a length of at least about 6 feet. The rigid support structure configured to maintain the sensor unit within an internal structure for monitoring using the electronic sensor component.

Abstract: A device for transferring adverse event information from a plurality of remote hydrants to a municipal monitoring server comprises detecting an adverse event in a hydrant that relates to an adverse hydrant condition; transferring data representative of the adverse condition to a host server by routing the data along a predefined hopping path; and transferring the data from the host monitor to the municipal monitoring server. A system for detecting adverse events at a hydrant and event information to a municipal monitoring sever is also disclosed.

Abstract: A device for transferring adverse event information from a plurality of remote hydrants to a municipal monitoring server comprises detecting an adverse event in a hydrant that relates to an adverse hydrant condition; transferring data representative of the adverse condition to a host server by routing the data along a predefined hopping path; and transferring the data from the host monitor to the municipal monitoring server. A system for detecting adverse events at a hydrant and event information to a municipal monitoring sever is also disclosed.

Abstract: A method for transferring adverse event information from a plurality of remote hydrants to a municipal monitoring server comprises detecting an adverse event in a hydrant that relates to an adverse hydrant condition; transferring data representative of the adverse condition to a host server by routing the data along a predefined hopping path; and transferring the data from the host monitor to the municipal monitoring server. A system for detecting adverse events at a hydrant and event information to a municipal monitoring sever is also disclosed.

Abstract: Organosilicon compounds are prepared by the addition reaction of a gaseous unsaturated hydrocarbon with a silane or siloxane containing at least one silicon-bonded hydrogen atom in the presence of a hydrosilylation catalyst in a liquid reaction medium. In this process the unsaturated hydrocarbon and optionally the silane or siloxane is dispersed into the liquid reaction medium by a jet eductor (also known as a venturi pump) device and the resultant gas-in-liquid dispersion is introduced into a bubble reactor.

Abstract: A bit quality evaluator receives a sequence of bits. The bit sequence is provided to a decoding device that performs soft decision convolutional decoding on the sequence of bits. An off track event detector detects an occurrence of a trellis decode path change during the convolutional decoding operation and identifies a first symbol proximate corresponding to the occurrence of the trellis decode path change. An erasure decision circuit identifies at least the first symbol for erasure. The output of the first decoder and the erasure decision circuit are received at a second decoder, which decoder decodes the output of the first decoder after erasing at least the first symbol. The erasure decision circuit may also identify additional symbols for erasure using performance measures of the trellis decode path and using quality measures of the sequence of bits.

Abstract: An apparatus includes: a logic circuit with electronic memory to: monitor signal traffic with at least one client and a computer network to determine, without changing the signal traffic, for each client, a network address and a port to which that client is connected; provide to a first dynamic table the network address and port for each said client; access an authentication server that has a second table of user names and corresponding passwords for network login, in which the second table also includes for each user name and password a corresponding virtual local network (VLAN) membership and/or VLAN tag and/or Quality of Service (QoS); and add to the first dynamic table the user name, VLAN membership, VLAN tag and QoS information learnt from the authentication server in the second table.

Abstract: An apparatus includes: a logic circuit with electronic memory to: monitor signal traffic with at least one client and a computer network to determine, without changing the signal traffic, for each client, a network address and a port to which that client is connected; provide to a first dynamic table the network address and port for each said client; access an authentication server that has a second table of user names and corresponding passwords for network login, in which the second table also includes for each user name and password a corresponding virtual local network (VLAN) membership and/or VLAN tag and/or Quality of Service (QoS); and add to the first dynamic table the user name, VLAN membership, VLAN tag and QoS information learnt from the authentication server in the second table.

Abstract: A bit quality evaluator receives a sequence of bits. A quality measure is assigned to each bit within the sequence. The bit sequence and the quality measures are provided to a decoding device that performs soft decision convolutional decoding on the sequence of bits using the quality measure. An off-path detector detects an occurrence of a trellis decode path change during the convolutional decoding operation and identifies a first symbol proximate corresponding to the occurrence of the trellis decode path change. An erasure decision circuit identifies at least the first symbol for erasure. The output of the first decoder and the erasure decision circuit are received at a second decoder, which decoder decodes the output of the first decoder after erasing at least the first symbol. The erasure decision circuit may also identify additional symbols for erasure based on performance measures of the trellis decode path and the quality measure of the sequence of bits.

Abstract: A computer network including: at least one switch connecting at least one edge device to the remainder of the network, said at least one switch including: snooping apparatus using DHCP to monitor the signal traffic through the switch to or from the each edge device to determine, without changing the traffic signals, for each edge device, the MAC address, the IP address, and the port of the switch to which it is connected, and a dynamic table within said switch of, for each edge device, the MAC address, the IP address, and the port which it is connected, the contents of the table being provided by said snooping apparatus.