Abstract: A stop member for a device such as a syringe is inaccessibly disposed in a sleeve member. The ring member is also disposed about a portion of the stop member and in the sleeve member. The ring member is connected to the inside of the sleeve member by means of a frangible connection. When the sleeve member is twisted. the sleeve member and its connected ring member freely rotate about a portion of the stop member at the end of the syringe. When the sleeve member is axially pulled off the end of the syringe, the frangible connection breaks, and the sleeve member is removed, leaving the ring member and stop member disposed on the end of the syringe thereby indicating that the prefilled syringe has been tampered with.

Abstract: A system for eluting a daughter radioisotope from a parent radioisotope and containerizing the resultant eluate in an evacuated container having a rubber stopper, providing for delivery of eluant from a reservoir through a charge of the parent radioisotope in a generator and thence to a tubular needle adapted to be pierced through the stopper of the evacuated container for suctioning the eluant from the sealed eluant supply into the generator and for suctioning the resultant eluate into the container. The needle is at the lower end of a valve body having a valve plug rotatable therein between a closed and open position. The plug is adapted to be pushed down to push the valve body down to cause the needle to pierce the stopper, after which the plug is rotated to open position, in which it effects venting of the eluant reservoir to atmosphere, delivery of eluant from the reservoir to the generator, and delivery of eluate from the generator to the needle.