Patents by Inventor John P. Williams
John P. Williams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240166637Abstract: The present invention is related to the development of novel compounds and methods for the treatment and/or prevention of malaria. The compounds prevent the formation by the malaria parasite of the plasmodium surface anion channel (PSAC) on the surface of the host cell. The compounds and methods described herein are effective against infection by a wide variety of Plasmodia strains known as the causative agent of malaria.Type: ApplicationFiled: January 21, 2022Publication date: May 23, 2024Applicants: Microbiotix, Inc., The United States Of America As Represented By The Secretary, Department of Health and Human ServiceInventors: Samanthi L. Waidyarachchi, Son T. Nguyen, Xiaoyuan Ding, Sharmila Adhikari, John D. Williams, Norton P. Peet, Zachary D. Aron, Sanjay A. Desai, Michelle M. Butler
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Publication number: 20240156477Abstract: Various embodiments of the systems, methods, and devices are provided for controlled operation of an intravascular lithotripsy system for breaking up calcified lesions in an anatomical conduit. More specifically, control arrangements are disclosed concerning managing and/or providing electrical energy to generate an electrical arc between a set of spaced-apart electrodes disposed within fluid-fillable member are disclosed.Type: ApplicationFiled: November 10, 2023Publication date: May 16, 2024Inventors: John R. Ballard, Jason W. Staab, Austin P. Petronack, J. Samuel Batchelder, Jacob T. Williams, Donald D. Hanson, Thomas D. Brindley, Scott P. Boeshart, Jeffrey T. Moriarty
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Publication number: 20240156478Abstract: Various embodiments of the systems, methods, and devices are provided for controlled operation of an intravascular lithotripsy (“IVL”) system for breaking up calcified lesions in an anatomical conduit. More specifically, control arrangements are disclosed concerning managing and/or providing and/or assessing the electrical energy needed to generate an electrical arc between a set of spaced-apart electrodes disposed within a fluid-fillable member.Type: ApplicationFiled: November 10, 2023Publication date: May 16, 2024Inventors: John R. Ballard, Jason W. Staab, Austin P. Petronack, J. Samuel Batchelder, Jacob T. Williams, Donald D. Hanson, Thomas D. Brindley, Scott P. Boeshart, Jeffrey T. Moriarty
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Publication number: 20240156476Abstract: Various embodiments of the systems, methods, and devices are provided for controlled operation of an intravascular lithotripsy system for breaking up calcified lesions in an anatomical conduit. More specifically, control arrangements are disclosed concerning managing and/or providing electrical energy to generate an electrical arc between a set of spaced-apart electrodes disposed within a fluid-filled member configured to contain a conductive fluid.Type: ApplicationFiled: November 10, 2023Publication date: May 16, 2024Inventors: Jason W. Staab, Austin P. Petronack, John R. Ballard, J. Samuel Batchelder, Jacob T. Williams, Donald D. Hanson, Thomas D. Brindley, Scott P. Boeshart, Jeffrey T. Moriarty
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Publication number: 20240106700Abstract: The present disclosure generally relates to methods for sending event notifications. In some examples, a controller periodically sends messages concerning a status of an event corresponding to the controller. In some examples, at a first time while periodically sending the messages and in accordance with a determination that the status of the event has changed, the controller sends a message concerning data other than the status of the event. In some examples, at the first time while periodically sending the messages and in accordance with a determination that the status of the event has not changed, the controller continues to periodically send the messages without sending the message concerning data other than the status of the event.Type: ApplicationFiled: June 23, 2023Publication date: March 28, 2024Inventors: Ramy R. ASSELIN, John A. WILKEY, Jamie P. CARLSON, Stephanie L. LEGAULT, Abdul Rahman AL-SHAWA, Anil K. KANDANGATH, George E. WILLIAMS, Jangwon LEE, James D. BATSON, Fabien GONCALVES
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Publication number: 20230065034Abstract: Compounds are provided herein that antagonize corticotropin-releasing factor (CRF) receptors, in particular CRF receptor 1 (CRF1), as well as related preparations, compositions and methods for treating diseases and/or disorders that would benefit from the same such as congenital adrenal hyperplasia (CAH).Type: ApplicationFiled: December 1, 2020Publication date: March 2, 2023Inventors: Neil J. ASHWEEK, John P. WILLIAMS, Lev Alexander ZEGELMAN, Christina Marie COSTA, Scott STIRN, Shawn BRANUM, Jackie LE, John Lloyd TUCKER, Brian M. COCHRAN, David KUCERA, Donald HETTINGER, Max A. MELLMER
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Publication number: 20220409592Abstract: Compounds are provided herein, as well as related preparations, compositions and methods for treating diseases and/or disorders that would benefit from the same such as congenital adrenal hyperplasia (CAH).Type: ApplicationFiled: September 25, 2020Publication date: December 29, 2022Inventors: Evan SMITH, Sha LUO, Gordon Raphael LOEWEN, Neil J. ASHWEEK, John P. WILLIAMS
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Patent number: 11021449Abstract: Substituted 1,2,3-triazole compounds are disclosed which have utility in the treatment of a variety of neurological disorders. The compounds provided herein have the general structure: wherein R1, R2, R3 and n are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound provided herein in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for treating neurological disorders in a subject in need thereof.Type: GrantFiled: June 4, 2020Date of Patent: June 1, 2021Assignee: Neurocrine Biosciences, Inc.Inventors: Neil J. Ashweek, John P. Williams, Deborah Slee, Manisha Moorjani
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Publication number: 20200399229Abstract: Substituted 1,2,3-triazole compounds are disclosed which have utility in the treatment of a variety of neurological disorders. The compounds provided herein have the general structure: wherein R1, R2, R3 and n are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound provided herein in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for treating neurological disorders in a subject in need thereof.Type: ApplicationFiled: June 4, 2020Publication date: December 24, 2020Inventors: Neil J. Ashweek, John P. Williams, Deborah Slee, Manisha Moorjani
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Patent number: 10738017Abstract: Substituted 1,2,3-triazole compounds are disclosed which have utility in the treatment of a variety of neurological disorders. The compounds provided herein have the general structure: wherein R1, R2, R3 and n are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound provided herein in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for treating neurological disorders in a subject in need thereof.Type: GrantFiled: October 29, 2018Date of Patent: August 11, 2020Assignee: Neurocrine Biosciences, Inc.Inventors: Neil J. Ashweek, John P. Williams, Deborah Slee, Manisha Moorjani
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Publication number: 20190169137Abstract: Substituted 1,2,3-triazole compounds are disclosed which have utility in the treatment of a variety of neurological disorders. The compounds provided herein have the general structure: wherein R1, R2, R3 and n are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound provided herein in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for treating neurological disorders in a subject in need thereof.Type: ApplicationFiled: October 29, 2018Publication date: June 6, 2019Inventors: Neil J. Ashweek, John P. Williams, Deborah Slee, Manisha Moorjani
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Patent number: 10138214Abstract: Substituted 1,2,3-triazole compounds are disclosed which have utility in the treatment of a variety of neurological disorders. The compounds provided herein have the general structure: wherein R1, R2, R3 and n are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound provided herein in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for treating neurological disorders in a subject in need thereof.Type: GrantFiled: June 22, 2017Date of Patent: November 27, 2018Assignee: Neurocrine Biosciences, Inc.Inventors: Neil J. Ashweek, John P. Williams, Deborah Slee, Manisha Moorjani
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Publication number: 20170349558Abstract: Substituted 1,2,3-triazole compounds are disclosed which have utility in the treatment of a variety of neurological disorders. The compounds provided herein have the general structure: wherein R1, R2, R3 and n are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound provided herein in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for treating neurological disorders in a subject in need thereof.Type: ApplicationFiled: June 22, 2017Publication date: December 7, 2017Inventors: Neil J. Ashweek, John P. Williams, Deborah Slee, Manisha Moorjani
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Patent number: 9718789Abstract: Substituted 1,2,3-triazole compounds are disclosed which have utility in the treatment of a variety of neurological disorders. The compounds provided herein have the general structure: wherein R1, R2, R3 and n are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound provided herein in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for treating neurological disorders in a subject in need thereof.Type: GrantFiled: January 29, 2016Date of Patent: August 1, 2017Assignee: Neurocrine Biosciences, Inc.Inventors: Neil J. Ashweek, John P. Williams, Deborah Slee, Manisha Moorjani
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Publication number: 20160221968Abstract: Substituted 1,2,3-triazole compounds are disclosed which have utility in the treatment of a variety of neurological disorders. The compounds provided herein have the general structure: wherein R1, R2, R3 and n are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound provided herein in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for treating neurological disorders in a subject in need thereof.Type: ApplicationFiled: January 29, 2016Publication date: August 4, 2016Inventors: Neil J. Ashweek, John P. Williams, Deborah Slee, Manisha Moorjani
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Patent number: 7879862Abstract: CRF receptor antagonists are disclosed which may have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in mammals. The CRF receptor antagonists of this invention have the following structure: (I); and pharmaceutically acceptable salts, esters, solvates, stereoisomers and prodrugs thereof, wherein R1, R2a, R2b, Y, Het, n, o, R6, Ar and R7 are as defined herein. Compositions containing a CRF receptor antagonist in combination with a pharmaceutically acceptable carrier are also disclosed, as well as methods for use of the same.Type: GrantFiled: October 19, 2005Date of Patent: February 1, 2011Assignee: SmithKline Beecham (Cork) LimitedInventors: Marion Lanier, John Edward Tellew, John P. Williams
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Patent number: 7652035Abstract: CRF receptor antagonists are disclosed which may have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in mammals, such as stroke. The CRF receptor antagonists of this invention have the following structure: and pharmaceutically acceptable salts, esters, solvates, stereoisomers and prodrugs thereof, wherein R1, R2, n, R5, Ar, and Het are as defined herein. Compositions containing a CRF receptor antagonists in combination with a pharmaceutically acceptable carrier are also disclosed, as well as methods for use of the same.Type: GrantFiled: October 17, 2005Date of Patent: January 26, 2010Assignees: Neurocrine Bioscience, Inc., SB CorkInventors: Marion Lanier, Manisha Moorjani, John Edward Tellew, John P. Williams
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Patent number: 7617946Abstract: A unitary, removable, transportation ring for maintaining the closure of a covered container, such as a cylindrical paint can, snaps into place and securely maintains a lid on the container even in an environment of high pressure within the container. The ring is responsively operable in the presence of elevated and extreme pressures within the container to improve the engagement of the ring with the container, and to improve the engagement of the lid with the container, each in order to maintain the cover tightly sealed over the top opening of the container. An annular flange depends from the inner radial margin of the body of the ring and abuts the lid or cover of the container to maintain the engagement of the lid with the container.Type: GrantFiled: May 21, 2004Date of Patent: November 17, 2009Assignee: Bway CorporationInventors: Steven W. Loerop, Matthew E. Gleser, John P. Williams, Kenneth W. Loerop
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Patent number: 7556243Abstract: An apparatus for preventing a collision between a vehicle and an end of a Metal Beam Guide Fence. A transition device is attached to a modified section of the Metal Beam Guide Fence. The transition device and modified section are configured to allow passage of cables of a High Tension Cable Barrier through the Metal Beam Guide Fence and the transition device. The High Tension Cable Barrier redirects the colliding vehicle away from the end of the Metal Beam Guide Fence. The transition device and modified section are also configured to interact with the cables of the High Tension Cable Barrier to transfer and spread the collision load from the high tension cables to the Metal Beam Guide Fence.Type: GrantFiled: May 2, 2006Date of Patent: July 7, 2009Inventor: John P. Williams
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Publication number: 20080194589Abstract: CRF receptor antagonists are disclosed which may have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in mammals. The CRF receptor antagonists of this invention have the following structure: (I); and pharmaceutically acceptable salts, esters, solvates, stereoisomers and prodrugs thereof, wherein R1, R2a, R2b, Y, Het, n, o, R6, Ar and R7 are as defined herein. Compositions containing a CRF receptor antagonist in combination with a pharmaceutically acceptable carrier are also disclosed, as well as methods for use of the same.Type: ApplicationFiled: October 19, 2005Publication date: August 14, 2008Applicant: NEUROCRINE BIOSCIENCES, INC.Inventors: Marion Lanier, Zhiyong Luo, Manisha Moorjani, John Edward Tellew, John P. Williams, Xiaohu Zhang