Patents by Inventor John Podobinski
John Podobinski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190142971Abstract: The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.Type: ApplicationFiled: July 31, 2018Publication date: May 16, 2019Inventors: Stephen G. Hoge, Örn Almarsson, David D. Hile, Ciáran Lawlor, John Podobinski, Staci Sabnis, Antonin De Fougerolles, Divakar Ramakrishnan, Kristy M. Wood
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Patent number: 10258698Abstract: The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.Type: GrantFiled: March 14, 2014Date of Patent: April 16, 2019Assignee: ModernaTX, Inc.Inventors: Stephen G. Hoge, Örn Almarsson, David D. Hile, Ciarán Lawlor, John Podobinski, Staci Sabnis, Antonin de Fougerolles, Divakar Ramakrishnan, Kristy M. Wood
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Publication number: 20160038612Abstract: The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.Type: ApplicationFiled: March 14, 2014Publication date: February 11, 2016Inventors: Stephen G. Hoge, Öm Almarsson, David D. Hile, Ciarán Lawlor, John Podobinski, Staci Sabnis, Antonin de Fougerolles, Divakar Ramakrishnan, Kristy M. Wood
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Publication number: 20140356249Abstract: Systems and methods are provided for filtering a fluid containing nanoparticles. The systems and methods generally include introducing a stream of the nanoparticle-containing fluid into a holding vessel, and extracting at least a part of a nanoparticle-containing fluid accumulated in the holding vessel. The extracted nanoparticle-containing fluid is passed through a filtration module to separate a nanoparticle-containing retentate from a permeate, and the retentate is returned to the vessel. The filtration cycle can be repeated until a desired concentration of the nanoparticles is achieved in the holding vessel. In many embodiments, the generation of the nanoparticle-containing fluid and its filtration are performed concurrently.Type: ApplicationFiled: August 12, 2014Publication date: December 4, 2014Inventors: J. Michael Ramstack, John Podobinski
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Patent number: 8809492Abstract: Systems and methods are provided for filtering a fluid containing nanoparticles. The systems and methods generally include introducing a stream of the nanoparticle-containing fluid into a holding vessel, and extracting at least a part of a nanoparticle-containing fluid accumulated in the holding vessel. The extracted nanoparticle-containing fluid is passed through a filtration module to separate a nanoparticle-containing retentate from a permeate, and the retentate is returned to the vessel. The filtration cycle can be repeated until a desired concentration of the nanoparticles is achieved in the holding vessel. In many embodiments, the generation of the nanoparticle-containing fluid and its filtration are performed concurrently.Type: GrantFiled: September 10, 2013Date of Patent: August 19, 2014Assignee: Cerulean Pharma Inc.Inventors: J. Michael Ramstack, John Podobinski
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Publication number: 20140113137Abstract: In one aspect, the present invention provides a process for forming polymeric nanoparticles, which comprises using a static mixer to create a mixed flowing stream of an anti-solvent, e.g., by introducing a liquid anti-solvent into a static mixer, and introducing a polymer solution into the mixed flowing anti-solvent stream such that controlled precipitation of polymeric nanoparticles occurs. The nanoparticles can then be separated from the anti-solvent stream.Type: ApplicationFiled: December 30, 2013Publication date: April 24, 2014Applicant: Cerulean Pharma, Inc.Inventors: John Podobinski, J. Michael Ramstack, David S. Dickey
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Publication number: 20140010724Abstract: Systems and methods are provided for filtering a fluid containing nanoparticles. The systems and methods generally include introducing a stream of the nanoparticle-containing fluid into a holding vessel, and extracting at least a part of a nanoparticle-containing fluid accumulated in the holding vessel. The extracted nanoparticle-containing fluid is passed through a filtration module to separate a nanoparticle-containing retentate from a permeate, and the retentate is returned to the vessel. The filtration cycle can be repeated until a desired concentration of the nanoparticles is achieved in the holding vessel. In many embodiments, the generation of the nanoparticle-containing fluid and its filtration are performed concurrently.Type: ApplicationFiled: September 10, 2013Publication date: January 9, 2014Applicant: CERULEAN PHARMA INC.Inventors: J. Michael Ramstack, John Podobinski
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Patent number: 8618240Abstract: In one aspect, the present invention provides a process for forming polymeric nanoparticles, which comprises using a static mixer to create a mixed flowing stream of an anti-solvent, e.g., by introducing a liquid anti-solvent into a static mixer, and introducing a polymer solution into the mixed flowing anti-solvent stream such that controlled precipitation of polymeric nanoparticles occurs. The nanoparticles can then be separated from the anti-solvent stream.Type: GrantFiled: March 11, 2013Date of Patent: December 31, 2013Assignee: Cerulean Pharma, Inc.Inventors: John Podobinski, J. Michael Ramstack, David S. Dickey
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Publication number: 20130273117Abstract: In one aspect, the present invention provides a process for forming polymeric nanoparticles, which comprises using a static mixer to create a mixed flowing stream of an anti-solvent, e.g., by introducing a liquid anti-solvent into a static mixer, and introducing a polymer solution into the mixed flowing anti-solvent stream such that controlled precipitation of polymeric nanoparticles occurs. The nanoparticles can then be separated from the anti-solvent stream.Type: ApplicationFiled: March 11, 2013Publication date: October 17, 2013Inventors: John Podobinski, J. Michael Ramstack, David S. Dickey
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Patent number: 8546521Abstract: Systems and methods are provided for filtering a fluid containing nanoparticles. The systems and methods generally include introducing a stream of the nanoparticle-containing fluid into a holding vessel, and extracting at least a part of a nanoparticle-containing fluid accumulated in the holding vessel. The extracted nanoparticle-containing fluid is passed through a filtration module to separate a nanoparticle-containing retentate from a permeate, and the retentate is returned to the vessel. The filtration cycle can be repeated until a desired concentration of the nanoparticles is achieved in the holding vessel. In many embodiments, the generation of the nanoparticle-containing fluid and its filtration are performed concurrently.Type: GrantFiled: January 25, 2012Date of Patent: October 1, 2013Assignee: Cerulean Pharma Inc.Inventors: J. Michael Ramstack, John Podobinski
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Patent number: 8404799Abstract: In one aspect, the present invention provides a process for forming polymeric nanoparticles, which comprises using a static mixer to create a mixed flowing stream of an anti-solvent, e.g., by introducing a liquid anti-solvent into a static mixer, and introducing a polymer solution into the mixed flowing anti-solvent stream such that controlled precipitation of polymeric nanoparticles occurs. The nanoparticles can then be separated from the anti-solvent steam.Type: GrantFiled: May 24, 2012Date of Patent: March 26, 2013Assignee: Cerulean Pharma Inc.Inventors: John Podobinski, J. Michael Ramstack, David S. Dickey
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Publication number: 20120263653Abstract: In one aspect, the present invention provides a process for forming polymeric nanoparticles, which comprises using a static mixer to create a mixed flowing stream of an anti-solvent, e.g., by introducing a liquid anti-solvent into a static mixer, and introducing a polymer solution into the mixed flowing anti-solvent stream such that controlled precipitation of polymeric nanoparticles occurs. The nanoparticles can then be separated from the anti-solvent steam.Type: ApplicationFiled: May 24, 2012Publication date: October 18, 2012Applicant: CERULEAN PHARMA INC.Inventors: John Podobinski, J. Michael Ramstack, David S. Dickey
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Publication number: 20120196990Abstract: Systems and methods are provided for filtering a fluid containing nanoparticles. The systems and methods generally include introducing a stream of the nanoparticle-containing fluid into a holding vessel, and extracting at least a part of a nanoparticle-containing fluid accumulated in the holding vessel. The extracted nanoparticle-containing fluid is passed through a filtration module to separate a nanoparticle-containing retentate from a permeate, and the retentate is returned to the vessel. The filtration cycle can be repeated until a desired concentration of the nanoparticles is achieved in the holding vessel. In many embodiments, the generation of the nanoparticle-containing fluid and its filtration are performed concurrently.Type: ApplicationFiled: January 25, 2012Publication date: August 2, 2012Applicant: CERULEAN PHARMA INC.Inventors: J. Michael Ramstack, John Podobinski
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Patent number: 8207290Abstract: In one aspect, the present invention provides a process for forming polymeric nanoparticles, which comprises using a static mixer to create a mixed flowing stream of an anti-solvent, e.g., by introducing a liquid anti-solvent into a static mixer, and introducing a polymer solution into the mixed flowing anti-solvent stream such that controlled precipitation of polymeric nanoparticles occurs. The nanoparticles can then be separated from the anti-solvent stream.Type: GrantFiled: February 8, 2011Date of Patent: June 26, 2012Assignee: Cerulean Pharma Inc.Inventors: John Podobinski, J. Michael Ramstack, David S. Dickey
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Publication number: 20110237748Abstract: In one aspect, the present invention provides a process for forming polymeric nanoparticles, which comprises using a static mixer to create a mixed flowing stream of an anti-solvent, e.g., by introducing a liquid anti-solvent into a static mixer, and introducing a polymer solution into the mixed flowing anti-solvent stream such that controlled precipitation of polymeric nanoparticles occurs. The nanoparticles can then be separated from the anti-solvent stream.Type: ApplicationFiled: February 8, 2011Publication date: September 29, 2011Applicant: CERULEAN PHARMA INC.Inventors: John Podobinski, J. Michael Ramstack, David S. Dickey