Patents by Inventor John Q. Trojanowski

John Q. Trojanowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for producing and using homogenous neuronal cell transplants
    Patent number: 5792900
    Abstract: The invention concerns populations of homogenous, post-mitotic human NT2N neurons that are useful for generating animal systems for study of neuron function. Also disclosed are methods of preparing animals that are useful for study of neurological function. In these methods, differentiated NT2N cells are stably implanted into host rodent animals.
    Type: Grant
    Filed: June 7, 1996
    Date of Patent: August 11, 1998
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Virginia M.-Y. Lee, John Q. Trojanowski
  • Method of screening for Alzheimer's disease or disease associated with the accumulation of paired helical filaments
    Patent number: 5733734
    Abstract: Substantially purified antibodies, including substantially purified monoclonal antibodies, which are specifically reactive with .tau. that has an abnormally phosphorylated serine in the sequence LysSerProVal SEQ ID NO:3 are disclosed. Methods of screening persons for diseases associated with pair helical filaments, including Alzheimer's disease, by detection of .tau. that has an abnormally phosphorylated serine in the sequence LysSerProVal SEQ ID NO:3 in test samples taken from such persons and test kits useful to perform such methods are disclosed.
    Type: Grant
    Filed: October 29, 1993
    Date of Patent: March 31, 1998
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: John Q. Trojanowski, Virginia M-Y. Lee
  • Method of detecting abnormally phosphorylated tau(.tau.)
    Patent number: 5601985
    Abstract: Antibodies specifically reactive with an abnormally phosphorylated peptide comprising SEQ ID NO: 3 wherein a serine in SEQ ID NO: 3 is abnormally phosphorylated are provided. Methods of detecting abnormally phosphorylated .tau. in a test sample and methods of diagnosing Alzheimer's Disease with these antibodies are also provided.
    Type: Grant
    Filed: June 27, 1995
    Date of Patent: February 11, 1997
    Assignee: Trustees of the Univ. of Pennsylvania
    Inventors: John Q. Trojanowski, Virginia M-Y. Lee
  • Method of stabilizing microtubules
    Patent number: 5580898
    Abstract: A method of stabilizing microtubules which are destabilized due to insufficient levels of normal human tau protein is disclosed. The method comprises the steps of contacting a microtubule that is destablizing due to a deficiency in normal tau protein with an amount of taxol sufficient to stabilize microtubules.
    Type: Grant
    Filed: May 24, 1994
    Date of Patent: December 3, 1996
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: John Q. Trojanowski, Virginia M-Y. Lee
  • Modified avidin-biotin technique
    Patent number: 5281521
    Abstract: A method for preparing an antigen specific probe is provided by incubating a primary antigen specific monoclonal antibody with a biotinylated secondary antibody to produce a complex of the primary and secondary antibodies. The staining pattern produced by these probes reflects the specificity of the monoclonal antibody in the complex and the labeling of irrelevant, endogenous immunoglobulins is reduced substantially. This novel, indirect immunohistochemical method can be used to study normal and diseased tissues using a variety of monoclonal antibodies.
    Type: Grant
    Filed: July 20, 1992
    Date of Patent: January 25, 1994
    Assignee: The Trustees of The University of Pennsylvania
    Inventors: John Q. Trojanowski, Virginia M-Y. Lee