Abstract: The present invention relates to peptide substrates selectively recognized by botulinum toxin type A, BoNT/E, and their uses, in particular for carrying out methods for detecting, identifying and/or diagnosing botulinum toxin type E.

Abstract: The present invention relates to peptide substrates selectively recognized by botulinum toxin type A, BoNT/E, and their uses, in particular for carrying out methods for detecting, identifying and/or diagnosing botulinum toxin type E.

Abstract: One major problem in diagnosis methods presently available for anthrax is that these methods require several days to produce a result. The only existing treatment for anthrax requires administration soon after infection at a time when patients are exhibiting only mild flu-like symptoms. Thus, a patient may be days beyond the time when treatment would be effective by the time a diagnosis is made. The present invention reduces diagnosis time to as little as four hours providing same day identification of anthrax radically increasing the odds of delivering proper treatment and patient recovery. The rapid identification of anthrax lethal factor activity exhibited by the instant invention is also amenable to in vivo screening protocols for the discovery and development of anthrax vaccines and lethal factor inhibitors. The instant invention isolates and concentrates lethal factor and lethal toxin from nearly any biological sample.

Abstract: Apparatus may be provided including a spectrum analyzer and decision circuitry. The spectrum analyzer may be configured to ascertain wireless signal signature data from a wide range of frequency bands. The decision circuitry may be configured to modify operation of one or both of a receiver and a transmitter based on the signal signature data.

Abstract: A process of quantifying proteins in a complex mixture is provided. The invention has utility in quantifying proteins in a complex preparation of uni- or multivalent commercial or research vaccine preparations.

Abstract: One major problem in diagnosis methods presently available for anthrax is that these methods require several days to produce a result, are rendered unusable after antibiotic use, or are not quantifiable. The only existing treatment for anthrax requires administration soon after infection at a time when patients are exhibiting only mild flu-like symptoms. Thus, by the time a diagnosis is made a patient may be days beyond the time when treatment would be effective. The present invention reduces diagnosis time to as little as four hours providing same day identification of anthrax radically increasing the odds of delivering proper treatment and patient recovery. The rapid identification of anthrax edema factor activity exhibited by the invention is also amenable to in vivo screening protocols for the discovery and development of anthrax vaccines, anti-toxins and edema factor inhibitors. The invention isolates and concentrates edema factor and edema toxin from nearly any sample.

Abstract: One major problem in diagnosis methods presently available for anthrax is that these methods require several days to produce a result. The only existing treatment for anthrax requires administration soon after infection at a time when patients are exhibiting only mild flu-like symptoms. Thus, a patient may be days beyond the time when treatment would be effective by the time a diagnosis is made. The present invention reduces diagnosis time to as little as four hours providing same day identification of anthrax radically increasing the odds of delivering proper treatment and patient recovery. The rapid identification of anthrax lethal factor activity exhibited by the instant invention is also amenable to in vivo screening protocols for the discovery and development of anthrax vaccines and lethal factor inhibitors. The instant invention isolates and concentrates lethal factor and lethal toxin from nearly any biological sample.

Abstract: Each user can contribute to an original search and to refining the results of the search. Preferences of all of the users are considered in the search even while those preferences can be kept private. In some embodiments of the present invention, at least two users each submit a search query. The multiple search queries are logically combined to produce one set of search results. The results can be reviewed by the users and refined if necessary. In some embodiments, a search query can be specified by a single user, but the search engine takes into consideration the stored preferences of multiple users (in addition to the search query itself, of course).

Abstract: A process of quantifying proteins in a complex mixture is provided. The invention has utility in quantifying proteins in a complex preparation of uni- or multivalent commercial or research vaccine preparations.

Abstract: A method and apparatus for detecting a frequency band and mode of operation using recursive sampling and narrowing down is disclosed. The method comprises sampling (215) by a multi-mode wireless communication device, a broad operational frequency spectrum at a first sampling rate to produce a first set of discrete signal samples. Then, the wireless communication device compares (230, 240) at least one of the energy graphs of the first set of discrete signal samples with at least one protocol-specific signature to confirm (245), if an approximate match is found. When one or more approximate matches are found, the wireless communication device narrows down (250) the broad frequency spectrum to a reduced set of frequency band(s) that correspond to the matched protocol-specific signature(s). Then the steps of sampling (215), comparing (230, 240), confirming (245), and narrowing down (250) are recursively followed till a frequency band and mode of operation is confirmed.

Abstract: A method for priority-based admission control in a network, comprises receiving an admission request for transmitting an information flow to a network through a communication channel and determining an admissible region within a range of a channel data rate of a communication channel for an information flow in response to a priority of the information flow, where the priority of the information flow is one of a plurality of priorities of information flow. The admissible region is one of a plurality of admissible regions within the channel data rate range that correspond to different ones of the plurality of priorities of information flow, respectively, and each of the plurality of admissible regions within the channel data rate range is useable for transmitting information flow with a respective one of the plurality of priorities.

Abstract: Disclosed are techniques that allow users to collaborate in a search. Each user can contribute to an original search and to refining the results of the search. Preferences of all of the users are considered in the search even while those preferences can be kept private. In some embodiments of the present invention, at least two users each submit a search query. The multiple search queries are logically combined to produce one set of search results. The results can be reviewed by the users and refined if necessary. In some embodiments, a search query can be specified by a single user, but the search engine takes into consideration the stored preferences of multiple users (in addition to the search query itself, of course).

Abstract: Disclosed is a personal communication device (called here the “local device”) that “looks around” to discover the presence of other personal communication devices (“remote devices”) in the near neighborhood. Using various techniques, the local device attempts to discover who is associated with each remote device that it discovers. The local device also attempts to assign a position value to each discovered remote device. Using this information, the local device constructs a “presence map” for its user, the map showing who is nearby. By consulting the presence map, the user of the local device can associate a name with each person in the near neighborhood. In some embodiments, the presence map is a virtual two- or three-dimensional representation of the neighborhood surrounding the user of the local device.

Abstract: A method for priority-based admission control in a network, comprises receiving an admission request for transmitting an information flow to a network through a communication channel and determining an admissible region within a range of a channel data rate of a communication channel for an information flow in response to a priority of the information flow, where the priority of the information flow is one of a plurality of priorities of information flow. The admissible region is one of a plurality of admissible regions within the channel data rate range that correspond to different ones of the plurality of priorities of information flow, respectively, and each of the plurality of admissible regions within the channel data rate range is useable for transmitting information flow with a respective one of the plurality of priorities.

Abstract: The present invention is directed to a method for detecting the presence of clostridial neurotoxins in a sample by mixing a sample with a peptide that can serve as a substrate for proteolytic activity of a clostridial neurotoxin; and measuring for proteolytic activity of a clostridial neurotoxin by a mass spectroscopy technique. In one embodiment, the peptide can have an affinity tag attached at two or more sites.

Abstract: A method and apparatus for detecting a frequency band and mode of operation using recursive sampling and narrowing down is disclosed. The method comprises sampling (215) by a multi-mode wireless communication device, a broad operational frequency spectrum at a first sampling rate to produce a first set of discrete signal samples. Then, the wireless communication device compares (230, 240) at least one of the energy graphs of the first set of discrete signal samples with at least one protocol-specific signature to confirm (245), if an approximate match is found. When one or more approximate matches are found, the wireless communication device narrows down (250) the broad frequency spectrum to a reduced set of frequency band(s) that correspond to the matched protocol-specific signature(s). Then the steps of sampling (215), comparing (230, 240), confirming (245), and narrowing down (250) are recursively followed till a frequency band and mode of operation is confirmed.

Abstract: Apparatus may be provided including a spectrum analyzer and decision circuitry. The spectrum analyzer may be configured to ascertain wireless signal signature data from a wide range of frequency bands. The decision circuitry may be configured to modify operation of one or both of a receiver and a transmitter based on the signal signature data.

Abstract: A wireless communication device (100) including a high-speed data buffer coupled to a first transceiver by a bus, and an application processor having a data buffer associated with the application processor. The associated data buffer is coupled to a high-speed data buffer and to a second transceiver by the bus, wherein the application processor is configured to control the transfer of data between the associated data buffer and the high-speed data buffer and to control the transfer of data between the associated data buffer and the second transceiver.

Abstract: System and method for receiving a call in a wireless device. A notification message is received over a first radio access technology (RAT) that another wireless device wants to engage in the call. At least one other RAT is identified that can be utilized to connect the call. The at least one other RAT is selected to connect the call. A connection is initiated through utilization of the at least one other RAT.

Abstract: A pair of anvils (50,54) are respectively fixed to and movable with respect to a base (12). Each anvil has a surface (52,56) of given topography, preferably a flat surface. The surfaces are spaced in parallel from one another at an initial gap so that the anvil surfaces do not contact one another. The movable anvil (50) can be moved away from the fixed anvil (54), such as by a cam (44) and follower (38), and the surfaces are maintained in parallel preferably by a parallelogram constant force flexure assembly (26). The cam is set to maintain a minimum space between the surfaces and to protect them from damage, in the event the movable anvil were accidently dropped towards the non-movable anvil. Parallelism between the surfaces is initially established preferably by an adjustment mechanism comprising a trivet/turnbuckle assembly (58). A displacement transducer (22) is coupled to the movable anvil for measuring the gap as determined by the thickness of a gage or product placed between the surfaces of the anvils.